Self-leadership is one of the critical power and control centers that drives organizations. Although senior management controls employees, employees determine how much of management's requests are implemented in the final stage. This article investigates the role of self-leadership and psychological empowerment in job performance. The purpose of this paper is to examine the effect of employees' use of self-leadership strategies on their job performance and to determine whether psychological empowerment has a mediating role in this relationship. Data were obtained by the voluntary participation of 512 employees operating in various sectors (The majority of them are those working in the insurance sector with 69.3%.) in Turkey. A convenience sampling method was used to collect the questionnaires. The SPSS program was used to analyze the data sets obtained. And, the mediator analysis was performed with PROCESS Macro on model 4. It has been found that psychological empowerment has a partial mediating effect on the relationship between self-leadership strategies and job performance. Study results show that employees' self-management potential is a vital business resource, and it is possible to evaluate this resource effectively with self-leadership strategies. The paper contributes to self-leadership and psychological empowerment literature and offers practical implications for organizations.