Purpose—The purpose of this study is to assess the impact of Information Systems (ISs) implementation in Greek industry. The main issues that are explored through this survey in regards to IS adoption are the financial and nonfinancial benefits that are derived due to IS adoption. The study also investigates the effect that IS adoption had in several business areas in regards to the factor of financial performance. Design/methodology/approach—The survey that was conducted was questionnaire based. Of the 96 valid responses that were received, 83 of them implemented at least one IS. Those 83 responses were analyzed statistically. Several statistical tools were used for that, such as: nonparametric χ2 tests for homogeneity, Cronbach Alpha method for the reliability of the questionnaire, and Mann–Whitney U tests. Findings—The results suggest that the majority of industry in Greece has implemented—at least—the ERP to conduct their business. In addition, most of them use a combination of not more than three ISs. The respondents are also satisfied by the financial impact of IS adoption. Inventory and warehouse management, along with customer service, were most positively affected by IS implementation. On the other hand, returned products reduction and the relationship with the suppliers were less positively affected by IS adoption. Research limitation/implications—The study has a limitation of being conducted in North Greece and not in the whole country. Originality/value—The paper constitutes an empirical research in regarding the financial and nonfinancial contribution of IS adoption in Greek industry. There are rather limited studies that have been conducted in Greece regarding IS implementation and the impact it poses in business affairs. The financial crisis along with the political instability that Greece has faced in the last decade makes it interesting to explore the influence of IS adoption in manufacturing enterprises. Usually, those studies are conducted in more developed countries where the financial and political environment is more stable.