“…The schistosomal granuloma thus satisfies the characteristics of a complex system, such as dynamism, reconstruction, homeostasis, and self‐organization. The same parameters are frequently applied to ecosystems in nature (Kay, 1991; Brulisauer, Bradfield & Maze, 1996; Levin, 1998; Wagendorp et al ., 2006; Xu et al ., 2012; Miller, Mote & Ranseyer, 2019) and, likewise, granulomas work as spatial units determined by a particular arrangement of their ECM products, showing well‐defined boundaries and providing a mechanical scaffold for adhesion, differentiation, and migration of distinct cell populations (el‐Meneza et al ., 1989; Lenzi et al ., 2006).…”