An Empirical Study to assess the Pattern and Predictors of Adverse Drug Reactions associated with Polypharmacy in the Department of General Medicine

Introduction: Patients with psychiatric disorders receives multiple medications associated with their comorbid conditions and mental illness increasing the risk of drug related problems leading to frequent hospitalization, healthcare expenditure and reduced quality of life. Aim/Objective: To assess and evaluate the Drug Related Problems (DRPs) encountered in patients with psychiatric disorders in a Secondary Care Hospital in Ras Al-Khaimah. Methodology: A prospective observational study was carried out for a period of six months in the department of psychiatry of a secondary care teaching hospital. All the necessary details including the demographics, drug therapy and laboratory parameters were collected from the patient case records. The patient medication orders were reviewed and screened for any DRPs. The identified DRPs were documented and later evaluated to identify the types, frequency, class of drugs involved and for the level of clinical significance by using the descriptive statistics. Results: A total of 61 DRPs were identified from 50 patients. Male predominance was noted over females. DRPs were commonly seen in patients aged between 21-40 years of age. Schizophrenia (42%) was the most common psychiatric illness identified in the study. The most common DRPs was found to be drug-drug interaction (36.06%) followed by adverse drug reaction (27.86%) and medication non-adherence (24.59%). The level of significance of DRPs was found to be ‘minor’ significance in the grade. Conclusion: The study identifies the DRPs in patients with psychiatric illness and necessitates the need for a regular medication review which will help to rationalize the drug therapy, achieve better therapeutic outcomes and improved quality of patient care.

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Assessment of Drug related problems Encountered in Patients with Psychiatric disorders in a Secondary Care Hospital.

Shareef

Rao

Al-Bonni

et al. 2021

RJPT

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Adverse Drug Reaction Monitoring of Antidepressant Drugs in a Mental Health Institute in Odisha

Das

Nayak

Swain

2021

RJPT

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Introduction: Antidepressants are used primarily in the management of depressive and anxiety disorders. The occurrence of adverse drug reactions (ADRs) to antidepressants is a major challenge as it influences patient compliance. Aim: The aim of this study was to find out the ADR profile of antidepressant drugs in a mental health institute in Odisha. Materials and Methods: This is a cross sectional observational study conducted in Department of Pharmacology in collaboration with Mental Health Institute (Centre of Excellence) S.C.B Medical College and Hospital, Cuttack from September 2017 to September 2019. Patients who received at least one antidepressant drug were included in the study irrespective of age and sex. Data were collected by interviewing the patients or attendants and on detection of ADR, it was recorded on suspected ADR reporting form designed by PvPI. Causality, severity and preventability of ADRs were assessed by, WHO-UMC causality assessment, modified Hartwig-Siegel Scale and modified Schumock-Thornton criteria respectively. Results: Out of 180 patients taking antidepressants, ADRs were reported in 24% of patients, with either possible or probable causality. None were labelled as certain. ADRs were observed in 50% of patients who received TCAs and among 34.5% who received polytherapy. Insomnia (27%), fatigue (17%) and agitation (13%) were most common ADRs. Most of the ADRs were of mild severity (91%) and not preventable (84%). Conclusion: Insomnia, fatigue and agitation were among most common ADRs. There was increased chance of ADRs with polytherapy and use of TCAs. Most ADRs were mild and not preventable.

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Pharmaceutical care program for Polymedicated elderly patients visiting Community Pharmacies in UAE during COVID-19 Pandemic: A Study Protocol

Dawood

Alomar

Palaian

2022

RJPT

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Background: The profession of pharmacy nowadays is expanding from dispensing medication to evidence-based, patient-centered approach, in which optimizing pharmacologic therapy is the goal. Community pharmacists can optimize the overall quality of care especially in rural populations where people most of the time can’t afford to visit physician. Pharmacist caring of patients is the new pharmacist’s role. Community pharmacist can motivate patients to adhere to their medications. Medication review and patients’ monitoring contribute to resolve serious problems in health care system. Methods: This study involves four phases. Phase one implies training of community pharmacists. Phase two is quantitative and involves baseline evaluation of recruited patients. Phase three is the interventional phase. It is also quantitative and aims to assess the impact of pharmaceutical care service on elderly patients with polypharmacy in three selected pharmacies in Ajman and Sharjah through Medication Adherence Rating Scale (MARS) questionnaire, and Short Form 36 (SF-36) questionnaire for health status, and quality of life. These two questionnaires will be filled by elderly patients first upon signing consent form, before the pharmacist intervention, and in the two interviews following the intervention. Phase four is qualitative and aims to assess the experience of the participating community pharmacists and explore their perception regarding the pharmaceutical care service through focused group discussion. Discussion: This research is the first to be conducted in United Arab Emirates. Therefore, findings will reveal the possibility and preparedness of pharmacists to perform medication review and patients’ monitoring and follow up. Additionally, due to the unusual circumstances of COVID-19 pandemic, innovative ways will be used to perform such service.

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An Empirical Study to assess the Pattern and Predictors of Adverse Drug Reactions associated with Polypharmacy in the Department of General Medicine

Cited by 8 publications

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Assessment of Drug related problems Encountered in Patients with Psychiatric disorders in a Secondary Care Hospital.

Assessment of Drug related problems Encountered in Patients with Psychiatric disorders in a Secondary Care Hospital.

Adverse Drug Reaction Monitoring of Antidepressant Drugs in a Mental Health Institute in Odisha

Pharmaceutical care program for Polymedicated elderly patients visiting Community Pharmacies in UAE during COVID-19 Pandemic: A Study Protocol

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