An Emulsion Containing Hyaluronic Acid and Chondroitin Sulfate for Prevention and Treatment of Radiation Dermatitis in Breast Cancer Patients - A Randomized Study

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

“…Insufficient evidence was reported to support the use of any interventions for ARD prevention. 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 “n” indicates the number of studies. NS, not specified; RCT, randomized controlled trial; ARD, radiation dermatitis.…”

“… 145 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 Alternative and multi-component therapies 11 (4) 422 (30; 1–90) Hydrotherapy (1); Acupuncture (1); Mixed emulsion (1); Other (11) Breast (4); Head and neck (1); Multiple (6) Insufficient evidence was reported to support the use of any interventions for ARD management. 179 , 186 , 189 , 200 , 238 , 239 , 240 , 241 , 242 , 243 , 244 “n” indicates the number of studies. RCT, randomized controlled trial; ARD, radiation dermatitis.…”

“…Alternative and multi-component therapies were assessed in 17 RCTs and 16 non-randomized studies 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 ( Appendix C, Table 7 ). Minimal difference was found between patients who used deodorant or antiperspirant and those who washed regularly, 167 , 168 did not use any intervention, 169 or used standard of care, 170 suggesting that antiperspirant/deodorant use should not be encouraged with the intent of preventing ARD.…”

“…Similarly, most other interventions had no preventative benefit across RCTs, such as alkaline water, 172 or minimal benefit confined to one RCT, such as repalysyal 180 or other emulsions. 179 , 182 Based on evidence from multiple RCTs, aluminum/deodorant use and washing with water and soap do not worsen ARD, but there is insufficient evidence to support their use in the prevention of ARD. Overall, evidence supporting the majority of alternative and multi-component therapies is lacking.…”

“…A total of 25 studies evaluated interventions in the natural and miscellaneous 145 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 and alternative and multi-component categories 179 , 186 , 189 , 200 , 238 , 239 , 240 , 241 , 242 , 243 , 244 ( Appendix C, Tables 11 and 12 ). Among all interventions, insufficient evidence was available to confirm efficacy.…”