An emulsion preparation for novel micro-porous polymeric hemi-shells

Naidoo, K; Rolfes, H.; Easton, Kim; Moolman, FS; Chetty, Avashnee; Richter, W.; Nilen, R.W.N.

doi:10.1016/j.matlet.2007.05.012

Cited by 16 publications

(17 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the amount of HPβCD (10∼30 mg) was significantly higher than previously reported (11,21), and sodium chloride (20 mg) was also added to the primary emulsion to maximize the osmotic pressure. As a consequence, the PLGA MPs prepared were hollow with highly porous surfaces, like the hemi-shells previously reported (35) (Fig. 1).…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 66%

“…bile salts), and proteins (e.g. albumin), have been used (35). However, in the present study, an albumincoating was favored because it decreases exposure of the PLGA backbone and causes inter-particulate electric repulsion due to its substantial negative charge.…”

Section: Discussionmentioning

confidence: 80%

Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes

et al. 2011

View full text Add to dashboard Cite

show abstract

“…173,174 This limitation can be overcome by using new miscible porogens or new synthesis strategies, like those that employ permanent geometric templates or scaffolds to avoid the leaching step. [175][176][177] Duncanson et al 169 introduced a self-assembling perfluorinateddendrimer-dye complex as a novel pore forming agent to generate monodisperse macroporous microspheres ( Fig. 17) in a microfluidic flow-focusing device (FFD).…”

Section: Microfluidic-based Porous Particle Fabrication Methodsmentioning

confidence: 99%

Macroporous materials: microfluidic fabrication, functionalization and applications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…However, the inability to deliver these cells to specific sites of injury as well as their lack of retention at the site are hurdles that need to be overcome. In order to address these issues the South African Council for Scientific and Industrial Research (CSIR) has developed novel ported PCL particles through a solvent evaporation process that has application in soft tissue bulking and more specifically in minimally invasive dermal filler procedures for wrinkle reduction ( Fig 1 ) [ 18 ]. These hollow ported particles were designed to serve both as an anchor point and a “tissue harbour” for cells, which may provide advantages over both the hydrogel ( e .…”

Section: Introductionmentioning

confidence: 99%

An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles

et al. 2018

Self Cite

View full text Add to dashboard Cite

The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and this makes them an ideal material for dermal filling purposes. Hollow PCL spheres were developed by the Council for Scientific and Industrial Research (CSIR) to serve both as an anchor point and a “tissue harbour” for cells. Particles were tested for cytotoxicity and cell adherence using mouse embryo fibroblasts (MEF). MEFs adhered to the particles and no significant toxic effects were observed based on morphology, cell growth, cell viability and cell cycle analysis, suggesting that the particles are suitable candidates for cell delivery systems in an in vivo setting. The objective of providing a “tissue harbour” was however not realized, as cells did not preferentially migrate into the ported particles. In vivo studies were conducted in BALB/c mice into whom particles were introduced at the level of the hypodermis. Mice injected with PCL particles (ported and non-ported; with or without MEFs) showed evidence of local inflammation and increased adipogenesis at the site of injection, as well as a systemic inflammatory response. These effects were also observed in mice that received apparently inert (polystyrene) particles. Ported PCL particles can therefore act as a cell delivery system and through their ability to induce adipogenesis, may also serve as a dermal bulking agent.

show abstract

An emulsion preparation for novel micro-porous polymeric hemi-shells

Cited by 16 publications

References 8 publications

Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes

Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes

Macroporous materials: microfluidic fabrication, functionalization and applications

An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles

Contact Info

Product

Resources

About