An enantioselective synthesis of β2-amino acid derivatives

Synthesis of Chiral Heterocyclic Phosphines for Application in Asymmetric Catalysis

“…In the asymmetric hydrogenation of a broad range of -acetamido and -acetamido acrylates with cationic Rh-catalysts 81-99 %ee were achieved [23,95]. Excellent enantioselectivities were also noted in the hydrogenation of -brancheddehydroamino acid precursors [96].…”

A General Approach to the Synthesis of β2‐Amino Acid Derivatives via Highly Efficient Catalytic Asymmetric Hydrogenation of α‐Aminomethylacrylates

“…In contrast, Rh‐DuPhos was better than Ru‐BINAP catalyst in the hydrogenation of the nitriles (best ee up to 48%). Particularly, α‐substituted β‐amidoacrylates were selected as hydrogenation substrates using chiral bidentate phosphines as ligands (BPE and Duphos), giving the products with modest ee values of up to 67% 14c. Recently, Zheng and co‐workers realized good Rh‐catalyzed enantioselective hydrogenation reactions of β‐unsubstituted and β‐substituted α‐(phthalimidomethyl)‐acrylates using monodentate phosphites or BoPhoz‐type ligands 14e,f.…”

Industrial Catalysts for Regio‐ or Stereo‐Selective Oxidations and Reductions. A Review of Key Technologies and Targets

“…b-Amino acids possess several biologically interesting properties including a remarkable stability of their derived amides towards peptidases: when used in the construction of peptidomimetics they confer the ability to fold into distinct secondary structures (similar to a-peptides) such as helices, turns, sheets and tubular structures. Such properties make them powerful tools for medicinal chemistry [5] . b-Homophenylalanine has been a widely reported as an example from this family of compounds.…”