An Endocrine Jaw Lesion: Dentist Perspective in Diagnosis

Kalapala, Lavanya; sai, Surapaneni Keerthi; Babburi, Suresh; Venigalla, Aparna; Pinisetti, Soujanya; Kotti, Ajay Benarji; Ganipineni, Kiranmai

doi:10.1155/2016/2582038

Cited by 6 publications

(12 citation statements)

References 11 publications

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“…4,[8][9][10]12,14 In younger people, brown tumor has been reported in multiple endocrine neoplasia syndromes (MEN1 and MEN2A). [4][5][6]14,15 Pregnancy has not been associated with brown tumor. Also, exophytic nonpedunculated lesions seen in our patient are rather uncommon.…”

Section: Discussionmentioning

confidence: 99%

“…Differential diagnosis includes other osteolytic lesions, most frequently solitary, with cortical thinning and tooth apex resorption, similar to odontogenic cysts and tumors. 4,8,12 We believe the diagnosis of brown tumors is a complex process and should comprise the following:…”

Section: Discussionmentioning

confidence: 99%

“…2,4,5,17,18 The results of laboratory tests are virtually pathognomonic for HPTH. However, accessory investigations, such as neck ultrasonography or fine needle biopsy of the parathyroids, may leave some doubts, since parathyroid adenoma/hyperplasia might be misdiagnosed as a colloid goiter or follicular neoplasm of the thyroid gland, as was the case in our patient.…”

Section: Discussionmentioning

confidence: 99%

“…The most common cause is a parathyroid adenoma (80-85%), although it can be difficult to distinguish between a normal and an abnormal gland, with multigland hyperplasia (15%) and carcinoma (1-2%) developing afterwards. 1,[3][4][5][6][7][8][9] Parathyroidectomy is the treatment of choice for symptomatic and progressive PHPT. [9][10][11] Multifocal brown tumors are a rare complication of hyperparathyroidism.…”

mentioning

confidence: 99%

“…1,11 A microscopic examination shows multinucleated giant cells with hemosiderin imparting the brown color and hence the name of the tumor. 2,4,9,11,13 Bone manifestations are associated with elevated serum alkaline phosphatase. The brown tumor of hyperparathyroidism is histologically very similar to central giant cell lesions (CGCL), a heterogenous group of jaw lesions.…”

mentioning

confidence: 99%

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Denosumab-related osteonecrosis of the jaw: A literature review

Nifosì¹,

Nifosì²,

Nifosì³

2017

Dent. Med. Probl.

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Multifocal brown tumors are a rare complication of primary hyperparathyroidism (PHPT). The reported prevalence of PHPT-related brown tumor is 3-4%. The tumor may histologically resemble any giant cell tumor of the jaws; hence, diagnostic errors or a delayed diagnosis of PHPT, when the lesion is the first clinical manifestation of this disease.We present a 27-year-old patient at 17-week gestation, who was diagnosed with an expansile mass in the left maxilla. Diagnostic tests also revealed two osteolytic lesions in the mandible.The patient underwent left maxillary segmental resection; the tumor was resected en bloc with teeth 25, 26. Histology confirmed the primary diagnosis of giant cell tumor. The observation was continued on an outpatient basis. Following delivery, progression of mandibular osteolytic lesions and maxillary tumor recurrence were found. Blood chemistry panel was ordered and the results raised a suspicion of primary hyperparathyroidism. Subsequent diagnostic tests revealed lower right parathyroid adenoma. Parathyroidectomy resulted in an almost complete regression of the mandibular lesions and a slight regression of the maxillary tumor.The paper presents diagnostic challenges associated with brown tumors as well as clinical, radiological, biochemical and histological manifestations thereof. The effect of pregnancy on the course of primary hyperparathyroidism is discussed and a diagnostic/therapeutic scheme is proposed when giant cells are present in a biopsy specimen.Key words: primary hyperparathyroidism, brown tumor of the maxilla/mandible, giant cell tumor of the maxilla/mandible, pregnancy epulides Słowa kluczowe: pierwotna nadczynność przytarczyc, guz brunatny szczęki i żuchwy, guz olbrzymiokomórkowy szczęki i żuchwy, guzy ciążowe

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Denosumab-related osteonecrosis of the jaw: A literature review

Nifosì¹,

Nifosì²,

Nifosì³

2017

Dent. Med. Probl.

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Osteitis fibrosa cystica

Rad

Deluxe

SpringerReference

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Gnathic Bones and Hyperparathyroidism: A Review on the Metabolic Bony Changes Affecting the Mandible and Maxilla in case of Hyperparathyroidism

Ibrahem

2020

Advances in Medicine

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Parathyroid glands secrete the parathyroid hormone that plays an essential role in bone remodeling. Excessive production of parathyroid hormone causes a common metabolic bone disorder known as hyperparathyroidism that is classified into primary, secondary, or tertiary. In hyperparathyroidism, the late bony complication is manifested as a giant cell osteolytic lesion called “brown tumor.” Primary hyperparathyroidism is usually a sporadic disorder, but in minority of cases it occurs in inherited forms, and one of these forms is the hyperparathyroidism-jaw tumor syndrome, which is characterized by primary hyperparathyroidism and ossifying fibroma in the mandible and/or maxilla.

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An Endocrine Jaw Lesion: Dentist Perspective in Diagnosis

Cited by 6 publications

References 11 publications

Denosumab-related osteonecrosis of the jaw: A literature review

Denosumab-related osteonecrosis of the jaw: A literature review

Osteitis fibrosa cystica

Gnathic Bones and Hyperparathyroidism: A Review on the Metabolic Bony Changes Affecting the Mandible and Maxilla in case of Hyperparathyroidism

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