2005
DOI: 10.1021/np0502802
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An Endophytic Fungus from Nothapodytes foetida that Produces Camptothecin

Abstract: A fungal endophytic isolate, camptothecin, has been isolated from the inner bark of the plant Nothapodytes foetidafrom the Western coast of India. The fungus, which belongs to the family Phycomycetes, produced the anticancer drug lead compound camptothecin (1) when grown in a synthetic liquid medium (Sabouraud broth) under shake flask and bench scale fermentation conditions. Compound 1 was identified by means of chromatographic and spectroscopic methods. It was also compared with an authentic example for its b… Show more

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Cited by 406 publications
(190 citation statements)
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“…In continuation of our previous work (39,2,3,40) on microbial chemistry of endophytic culture, herein, we demonstrate the outcome of media manipulations and precursor's treatment on the production of CPT from RJMEF001.…”
Section: Anma T E T a Lsupporting
confidence: 57%
See 1 more Smart Citation
“…In continuation of our previous work (39,2,3,40) on microbial chemistry of endophytic culture, herein, we demonstrate the outcome of media manipulations and precursor's treatment on the production of CPT from RJMEF001.…”
Section: Anma T E T a Lsupporting
confidence: 57%
“…The optimization of culture medium, the supply of biosynthetic precursors and genetic engineering are among the strategies adopted to increase alkaloid production in vitro (46). The production of CPT by endophytic fungi was initially reported by our group in 2005 (39). This important anticancer drug precursor molecule was obtained from endophyte RJMEF001 identified as…”
Section: Anma T E T a Lmentioning
confidence: 99%
“…These fungi can have effects on their hosts such as enhancement of stress, insect and disease resistance, [4][5][6][7] and also productivity improvement [8]. An endophytic fungus isolated from the inner barks of Nothapodytis foetida from the western coast of India produced a valuable alkaloid, viz.,Camptothecin [9].…”
Section: Introductionmentioning
confidence: 99%
“…This means of cancer curation makes use of the property of inhibition that the camptothecin compound has with the DNA of the cancerous cells. Some side effects in using this compound include diarrhea and anemia 99 .…”
Section: Indigofera Tinctoriamentioning
confidence: 99%