An endophytic fungus, <i>Penicillium simplicissimum</i> conjugated with C60 fullerene for its potential antimitotic, anti-inflammatory, anticancer and photodegradation activities

Govindappa, M.; Vishaka, A; Akshatha, B.S.; Popli, Dimple; Ningaraju, S.; Srinivas, Ch.; Raghavendra, Vinay B.

doi:10.1080/09593330.2021.1985621

Cited by 9 publications

(3 citation statements)

References 54 publications

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“… Stephania Dielsiana Antimicrobial activity [ 56 ] Penicillium vsp. ct-28 Corydlis tomentella Anticancer activity [ 57 ] P. roqueforti Solanum surattense Antioxidant activity [ 58 ] P. citrinum Azadirachta indica Antimicrobial activity [ 180 ] P. ochrochloronthe Taxus media Antimicrobial and anticancer activities [ 181 ] P. funiculosum Ficus elastic Antimicrobial activity [ 182 ] P. simplicissimum Loranthus micranthus Antimitotic, anti-inflammatory and anticancer activities [ 222 ] P. pinophilum Alloteropsis cimicina Antimicrobial and antioxidant activities [ 183 ] Alternaria Alternaria sp. MG1 Vitis quinquangularis Anticancer activity [ 59 ] Alternaria sp.…”

Section: Biomedical Applications Of Fungal Endophytesmentioning

confidence: 99%

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Hashem,

Attia,

Kandil

et al. 2023

Microb Cell Fact

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Human life has been significantly impacted by the creation and spread of novel species of antibiotic-resistant bacteria and virus strains that are difficult to manage. Scientists and researchers have recently been motivated to seek out alternatives and other sources of safe and ecologically friendly active chemicals that have a powerful and effective effect against a wide variety of pathogenic bacteria as a result of all these hazards and problems. In this review, endophytic fungi and their bioactive compounds and biomedical applications were discussed. Endophytes, a new category of microbial source that can produce a variety of biological components, have major values for study and broad prospects for development. Recently, endophytic fungi have received much attention as a source for new bioactive compounds. In addition, the variety of natural active compounds generated by endophytes is due to the close biological relationship between endophytes and their host plants. The bioactive compounds separated from endophytes are usually classified as steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones and enniatines. Moreover, this review discusses enhancement methods of secondary metabolites production by fungal endophytes which include optimization methods, co-culture method, chemical epigenetic modification and molecular-based approaches. Furthermore, this review deals with different medical applications of bioactive compounds such as antimicrobial, antiviral, antioxidant and anticancer activities in the last 3 years.

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Section: Biomedical Applications Of Fungal Endophytesmentioning

confidence: 99%

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Hashem,

Attia,

Kandil

et al. 2023

Microb Cell Fact

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“…An assessment of their safety profile was carried out using cytotoxicity screening on normal fibroblasts (Wi-38), followed by a comparison of their anticancer potential with 5-fluorouracil (5-FU) against three selected cancer cell lines (Caco-2, MDA-MB 231 and HepG-2). Fullerene@CA nanocomposite fibers, loaded with fullerene concentrations (0.1, 0.3, and 0.5 mg.g −1 ), are initially used as prescription carriers for anticancer treatments because fullerene has anticancer properties—according to previous studies 50 – 52 . The effect of Fullerene@CA nanocomposite fiber as an anti-cancer material was revealed, and it began to be evaluated as a standalone drug for anti-tumor growth where Bacakova et.al.…”

Section: Resultsmentioning

confidence: 99%

Nanocomposite fibers based on cellulose acetate loaded with fullerene for cancer therapy: preparation, characterization and in-vitro evaluation

El Fawal,

Abu-Serie,

Ali

et al. 2023

Sci Rep

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The current prevalence of cancerous diseases necessitates the exploration of materials that can effectively treat these conditions while minimizing the occurrence of adverse side effects. This study aims to identify materials with the potential to inhibit the metastasis of cancerous diseases within the human body while concurrently serving as therapeutic agents for their treatment. A novel approach was employed to enhance the anti-cancer properties of electrospun cellulose fibers by incorporating fullerene nanoparticles (NPs) into cellulose acetate (CA) fibers, resulting in a composite material called Fullerene@CA. This development aimed at utilizing the anti-cancer properties of fullerenes for potential therapeutic applications. This process has been demonstrated in vitro against various types of cancer, and it was found that Fullerene@CA nanocomposite fibers displayed robust anticancer activity. Cancer cells (Caco-2, MDA-MB 231, and HepG-2 cells) were inhibited by 0.3 and 0.5 mg.g−1 fullerene doses by 58.62–62.87%, 47.86–56.43%, and 48.60–57.73%, respectively. The tested cancer cells shrink and lose their spindle shape due to morphological changes. The investigation of the prepared nanocomposite reveals its impact on various genes, such as BCL2, NF-KB, p53, Bax, and p21, highlighting the therapeutic compounds' effectiveness. The experimental results demonstrated that the incorporation of NPs into CA fibers resulted in a significant improvement in their anti-cancer efficacy. Therefore, it is suggested that these modified fibers could be utilized as a novel therapeutic approach for the treatment and prevention of cancer metastasis.

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“…Fullerenes and their derivatives are very attractive due to their various promising biomedical applications such as anti-viruses, [1][2][3][4][5] antioxidant, neuroprotective, antimicrobial, and photodynamic therapy (PDT), which is attributed to their versatile physicochemical properties. [6][7][8][9][10][11][12] Among those in particular, owing to the photo-sensitive property, fullerene was recently used in PDT as a novel photosensitizer, which is an efficient technology with highly selective cytotoxicity against cancer cells in response to light, showing great prospects in fighting against cancers. 10,[13][14][15] To better realize such applications it is necessary to make the water-insoluble fullerenes 16,17 well disperse in the aqueous environment.…”

Section: Introductionmentioning

confidence: 99%

Highly aqueously stable C₆₀‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment

Wang,

Zhao,

Mulder

et al. 2023

Smart Medicine

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Fullerenes are a class of carbon nanomaterials that find a wide range of applications in biomedical fields, especially for photodynamic cancer therapy because of its photosensitive effect. However, hydrophobic fullerenes can only be dispersed in organic solvents which hinders their biomedical applications. Here, we report a facile method to prepare highly water‐dispersible fullerene (C60)‐polymer nanoparticles with hydrodynamic sizes of 50–70 nm. Hydrophilic random copolymers containing different ratios of polyethylene glycol methyl ether methacrylate and 2‐aminoethylmethacrylamide were synthesized for conjugating with C60 molecules through efficient nucleophilic Michael addition reaction between amine groups from hydrophilic polymer and carbon‐carbon double bonds from C60. As a result, the amphiphilic C60‐polymer conjugates could be well dispersed and nano‐assembled in water with a C60 concentration as high as 7.8 mg/mL, demonstrating a significant improvement for the solubility of C60 in an aqueous system. Owing to the high C60 content, the C60‐polymer nanoparticles showed a strong photodynamic therapy effect on human lung cancer cells (A549) under light irradiation (450 nm) in both 2D cell culture and 3D spheroid culture, while demonstrating ignorable cytotoxicity under dark. This highly efficient and convenient method to prepare water‐dispersible C60‐polymer conjugates may have a great impact on the future biomedical applications of fullerenes.

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An endophytic fungus, Penicillium simplicissimum conjugated with C60 fullerene for its potential antimitotic, anti-inflammatory, anticancer and photodegradation activities

Cited by 9 publications

References 54 publications

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Nanocomposite fibers based on cellulose acetate loaded with fullerene for cancer therapy: preparation, characterization and in-vitro evaluation

Highly aqueously stable C₆₀‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment

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An endophytic fungus, Penicillium simplicissimum conjugated with C60 fullerene for its potential antimitotic, anti-inflammatory, anticancer and photodegradation activities

Cited by 9 publications

References 54 publications

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Nanocomposite fibers based on cellulose acetate loaded with fullerene for cancer therapy: preparation, characterization and in-vitro evaluation

Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment

Contact Info

Product

Resources

About

Highly aqueously stable C₆₀‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment