2008
DOI: 10.1016/j.bmc.2008.09.044
|View full text |Cite
|
Sign up to set email alerts
|

An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

2
54
0

Year Published

2009
2009
2024
2024

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 67 publications
(56 citation statements)
references
References 8 publications
2
54
0
Order By: Relevance
“…Chemical components of this mushroom have been reported to have hericenones A and B as cytotoxic constituents, 7 hericenones C, D and E as stimulators of nerve growth factor synthesis, 8 hericenone J as an endoplasmic reticulum stress-suppressive substance, 9 hericerin as a pollen growth inhibitor 10 and antitumor-active polysaccharides 11 as the bioactive components. A bioassay-guided fractionation and chemical investigation of its MeOH extract resulted in the isolation of a new isoindolinone alkaloid named isohericenone (1), together with nine known compounds, namely isohericerin (2), 6 erinacerin B (3), 12 hericenone A (4), 7 hericenone J (5), 9 3,4-dihydro-5-methoxy-2-methyl-2-(4 0 -methyl-2 0 -oxo-3 0 -pentenyl)-9(7H)-oxo-2H-furo [3,4-h] benzopyran (6), 13 erinacerin A (7), 12 hericenone F (8), 14 hericenone D (9) 8 and hericenone E (10) 8 (Figure 1). Here, we describe the isolation and structural elucidation of (1) as well as the cytotoxic activities of compounds 1-10.…”
mentioning
confidence: 99%
“…Chemical components of this mushroom have been reported to have hericenones A and B as cytotoxic constituents, 7 hericenones C, D and E as stimulators of nerve growth factor synthesis, 8 hericenone J as an endoplasmic reticulum stress-suppressive substance, 9 hericerin as a pollen growth inhibitor 10 and antitumor-active polysaccharides 11 as the bioactive components. A bioassay-guided fractionation and chemical investigation of its MeOH extract resulted in the isolation of a new isoindolinone alkaloid named isohericenone (1), together with nine known compounds, namely isohericerin (2), 6 erinacerin B (3), 12 hericenone A (4), 7 hericenone J (5), 9 3,4-dihydro-5-methoxy-2-methyl-2-(4 0 -methyl-2 0 -oxo-3 0 -pentenyl)-9(7H)-oxo-2H-furo [3,4-h] benzopyran (6), 13 erinacerin A (7), 12 hericenone F (8), 14 hericenone D (9) 8 and hericenone E (10) 8 (Figure 1). Here, we describe the isolation and structural elucidation of (1) as well as the cytotoxic activities of compounds 1-10.…”
mentioning
confidence: 99%
“…erinaceus (Lion's mane mushroom), a wellknown edible mushroom, has been used as traditional medicine in several Asian countries to treat various human diseases. The compounds isolated from its fruiting bodies contain numerous biological activities, such as anti-tumor (18), hypolipidemic (26), hemagglutinating (17), cytotoxic (25), anti-microbial (27), endoplasmic reticulum (ER) stress-suppressive (20,24), and antioxidant activities (3). Especially, it has been reported that hericenones (11,12,13) and erinacines (4,15,16) stimulate nerve growth factor (NGF) synthesis in cultured astrocytes.…”
mentioning
confidence: 99%
“…We have recently found dilinoleoylphosphatidylethanolamine and hericenone-related compounds as protective principles from the mushroom, Hericium erinaceum. 3,4) In the course of further extensive screening, we found protective activity in an extract from the scrap cultivation bed of H. erinaceum. The cultivation bed is usually discarded by the mushroom growers after harvesting the fruiting bodies.…”
mentioning
confidence: 99%