An Enhanced Protocol for Constraint-Induced Aphasia Therapy II: A Case Series

Johnson, Marcus; Taub, Edward; Harper, Leslie H.; Wade, Jamie Tinker; Bowman, Mary H.; Bishop-McKay, Staci; Haddad, Michelle M.; Mark, Victor W.; Uswatte, Gitendra

doi:10.1044/1058-0360(2013/12-0168)

Cited by 38 publications

(44 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, this intervention was only an incomplete translation of CI Movement therapy. The initial aphasia treatment protocol was modified to more closely resemble the CIMT protocol (Johnson et al, 2014). To date, 6 patients have been treated with the new protocol (CIAT II).…”

Section: Therapymentioning

confidence: 99%

The functional significance of cortical reorganization and the parallel development of CI therapy

Taub

Uswatte

Mark

2014

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

For the nineteenth and the better part of the twentieth centuries two correlative beliefs were strongly held by almost all neuroscientists and practitioners in the field of neurorehabilitation. The first was that after maturity the adult CNS was hardwired and fixed, and second that in the chronic phase after CNS injury no substantial recovery of function could take place no matter what intervention was employed. However, in the last part of the twentieth century evidence began to accumulate that neither belief was correct. First, in the 1960s and 1970s, in research with primates given a surgical abolition of somatic sensation from a single forelimb, which rendered the extremity useless, it was found that behavioral techniques could convert the limb into an extremity that could be used extensively. Beginning in the late 1980s, the techniques employed with deafferented monkeys were translated into a rehabilitation treatment, termed Constraint Induced Movement therapy or CI therapy, for substantially improving the motor deficit in humans of the upper and lower extremities in the chronic phase after stroke. CI therapy has been applied successfully to other types of damage to the CNS such as traumatic brain injury, cerebral palsy, multiple sclerosis, and spinal cord injury, and it has also been used to improve function in focal hand dystonia and for aphasia after stroke. As this work was proceeding, it was being shown during the 1980s and 1990s that sustained modulation of afferent input could alter the structure of the CNS and that this topographic reorganization could have relevance to the function of the individual. The alteration in these once fundamental beliefs has given rise to important recent developments in neuroscience and neurorehabilitation and holds promise for further increasing our understanding of CNS function and extending the boundaries of what is possible in neurorehabilitation.

show abstract

Section: Therapymentioning

confidence: 99%

The functional significance of cortical reorganization and the parallel development of CI therapy

Taub

Uswatte

Mark

2014

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, such a traumatic event as a left ischemic stroke further alters cognitive functions and, thus, lowers substantially potential plasticity. Altogether, it is possible that CIAT training alone may not be sufficient to induce improvement compared to spontaneous recovery when training starts more than 12 months post-stroke and other supportive measures, such as a transfer package, may be needed [70]. Future studies should explore the possibility of enhancing the effects of language interventions by associating it with other forms of interventions that may exert effects on cognitive functions via different mechanisms such as: physical exercise [71], transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation [72,73].…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy

et al. 2017

View full text Add to dashboard Cite

BackgroundRecovery from post-stroke aphasia is a long and complex process with an uncertain outcome. Various interventions have been proposed to augment the recovery, including constraint-induced aphasia therapy (CIAT). CIAT has been applied to patients suffering from post-stroke aphasia in several unblinded studies to show mild-to-moderate linguistic gains. The aim of the present study was to evaluate the neuroimaging correlates of CIAT in patients with chronic aphasia related to left middle cerebral artery stroke.Material/MethodsOut of 24 patients recruited in a pilot randomized blinded trial of CIAT, 19 patients received fMRI of language. Eleven of them received CIAT (trained) and eight served as a control group (untrained). Each patient participated in three fMRI sessions (before training, after training, and 3 months later) that included semantic decision and verb generation fMRI tasks, and a battery of language tests. Matching healthy control participants were also included (N=38; matching based on age, handedness, and sex).ResultsLanguage testing showed significantly improved performance on Boston Naming Test (BNT; p<0.001) in both stroke groups over time and fMRI showed differences in the distribution of the areas involved in language production between groups that were not present at baseline. Further, regression analysis with BNT indicated changes in brain regions correlated with behavioral performance (temporal gyrus, postcentral gyrus, precentral gyrus, thalamus, left middle and superior frontal gyri).ConclusionsOverall, our results suggest the possibility of language-related cortical plasticity following stroke-induced aphasia with no specific effect from CIAT training.

show abstract

“…The approach has also been successfully applied to the treatment of other diagnostic groups (e.g., children with cerebral palsy [25][26], adults with traumatic brain injury [27][28], adults with multiple sclerosis [29]) and to other functional skills (e.g., ambulation [9], speech [30][31]) [6,9,17]. The most prominent outcome of the signature intervention for upper-limb hemiparesis is a very large increase in actual use of the paretic arm in daily life.…”

Section: Constraint-induced Movement Therapy Protocolmentioning

confidence: 99%

Training model for promoting translation from research to clinical settings: University of Alabama at Birmingham training for constraint-induced movement therapy

Morris

Taub²

2014

J Rehabil Res Dev

Self Cite

View full text Add to dashboard Cite

An Enhanced Protocol for Constraint-Induced Aphasia Therapy II: A Case Series

Abstract: These pilot results suggest in preliminary fashion that CIAT II may produce significant improvements in everyday speech.

Cited by 38 publications

References 52 publications

The functional significance of cortical reorganization and the parallel development of CI therapy

The functional significance of cortical reorganization and the parallel development of CI therapy

Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy

Training model for promoting translation from research to clinical settings: University of Alabama at Birmingham training for constraint-induced movement therapy

Contact Info

Product

Resources

About