An enzyme-free glucose sensor based on a difunctional diboronic acid for molecular recognition and potentiometric transduction

Chen, Hong‐Duo; Li, Long; Guo, Huimin; Wang, Xue Wei; Qin, Wei

doi:10.1039/c4ra15037f

Cited by 13 publications

(11 citation statements)

References 30 publications

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“…Inspired by this classic sensing system, many bis‐boronic acid molecules have been designed and synthesized for glucose detection. For example, Guo and co‐workers recently reported the one‐step synthesis of a bis‐boronic acid sensor (Scheme ), which showed higher binding affinity to glucose than to other tested monosaccharides . In another study, Yu and co‐workers developed a BINOL‐based fluorescent bis‐boronic acid sensor for the detection of glucose …”

Section: Boronic Acid‐appended Molecular Sensorsmentioning

confidence: 99%

“…For example, Guo and co-workersr ecently reported the one-step synthesis of ab isboronic acid sensor( Scheme 2), whichs howedh igher binding affinity to glucoset han to other tested monosaccharides. [8] In another study,Y ua nd co-workers developed aB INOL-based fluorescent bis-boronic acid sensor for the detection of glucose. [9] The difficulties related to the higher binding capacity of mono-boronic acids towards d-fructose versus d-glucose were resolved in work of Jianget al (Figure 2) in 2013.…”

Section: Introductionmentioning

confidence: 99%

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Boronic Acid‐Based Carbohydrate Sensing

Zhai

Sun

James

et al. 2015

Chemistry An Asian Journal

125

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The covalent boron-diol interaction enables elaborate design of boronic acid-based saccharide sensors. Over the last decade, this research topic has been well developed thanks to the integration of boronic acid chemistry with a range of techniques, including supramolecular chemistry, materials chemistry, surface modification, and nanotechnology. New sensing strategies and platforms have been introduced and remarkable progress has been achieved to fully utilize the unique property of boron-diol interaction and to improve the binding affinity towards different targets, especially under physiological conditions. In this review, the latest progress over the past 30 months (from late 2012 to early 2015) is highlighted and discussed to shed light on this versatile and promising platform for saccharide sensing.

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Section: Boronic Acid‐appended Molecular Sensorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Boronic Acid‐Based Carbohydrate Sensing

Zhai

Sun

James

et al. 2015

Chemistry An Asian Journal

125

View full text Add to dashboard Cite

show abstract

“…This protocol would be more useful if the ARS-PBA complex could be immobilized in membranes, as in the case of polymer membrane-based potentiometric sensors [115,116]. In this regard, polymeric liquid membranes containing PBAs have recently been reported as potentiometric sensors for sugars [117,118]. …”

Section: Pba-based Sensors For Glycoproteinsmentioning

confidence: 99%

Recent Progress in Electrochemical Biosensors for Glycoproteins

Akiba

Anzai

2016

Sensors

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This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements.

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“…Because α‐D‐glucofuranose contains two binding sites of syn‐periplanar diol groups to combine with two boronic acid , many methods of highly specific and sensitive detection of glucose have been achieved. For example, it is reported that some bis‐boronic acid molecules have been designed and synthesized for specific glucose detection through electrochemistry , fluorescence and surface plasmon resonance (SPR) .…”

Section: Introductionmentioning

confidence: 99%

Disposable Sandwich‐type Electrochemical Sensor for Selective Detection of Glucose Based on Boronate Affinity

Bai

Mao

et al. 2017

Electroanalysis

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A disposable sandwich‐type electrochemical sensor for selective detection of glucose was established. The primary receptor, 3‐aminophenylboronic acid was grafted covalently onto the surface of screen‐printed carbon electrodes through an in situ‐generated diazo‐reaction. Glucose was first captured by boronic acid group on the electrode, followed by captureing an electroactive ferroceneboronic acid (FcBA) as the secondary receptor to form bidentate glucose‐boronic complex. Electrochemical impedance spectroscopy was applied to characterize the construction of sandwich‐type disposable sensor. In the sandwich assay, current response of captured FcBA on the electrode was dependent on the concentration of glucose. The sandwich assay showed higher selectivity for glucose than that for fructose, mannose, galactose and other electroactive interferences including uric acid, ascorbic acid and dopamine, and exhibited a dynamic concentration range of glucose from 0.5 to 20.0 mmol L−1. The disposable sensor demonstrated a good reproducibility with 2.2 % relative standard deviation (RSD). In addition, the disposable glucose sensor was used in detection of the trace glucose in the clinical urine samples.

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An enzyme-free glucose sensor based on a difunctional diboronic acid for molecular recognition and potentiometric transduction

Abstract: Based on a diboronic acid for specific recognition of glucose, an enzyme-free potentiometric glucose sensor was developed.

Cited by 13 publications

References 30 publications

Boronic Acid‐Based Carbohydrate Sensing

Boronic Acid‐Based Carbohydrate Sensing

Recent Progress in Electrochemical Biosensors for Glycoproteins

Disposable Sandwich‐type Electrochemical Sensor for Selective Detection of Glucose Based on Boronate Affinity

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