An epidemic of occupational contact dermatitis from an acrylic glue

Abstract

Dermatological examinations were performed in 81 workers involved in the manufacture of electric coils for television displays, who had worked for 4 years in contact with a glue containing isobornyl acrylate, acrylic acid, N,N dimethyleneacrylamide, phosphine oxide, bis(2,6-dimethoxybenzoyl) (2,4,4-trimethylpentyl)- and beta-carboxyethyl acrylate. The glue was cured by 350-500-nm ultraviolet and visible radiations. Acrylate-specific dermal lesions were detected in 21 (25.9%) people. Occupational irritant contact dermatitis was diagnosed in 12 (15%) of the workers and occupational allergic contact dermatitis in 9 (11.2%). 12 people reacted to acrylates. Cross-reactions with methacrylates were not observed. The highest number of positive tests was obtained with triethyleneglycol diacrylate (10 people) and diethyleneglycol diacrylate (9), followed by 1,6-hexanediol diacrylate (5), 1,4-butanediol diacrylate (4), beta-carboxyethyl acrylate (3), tripropyleneglycol diacrylate (2) and pentaerythritol triacrylate (2). No cases of allergy to isobornyl acrylate, N,N-methylenebisacrylamide or phosphine oxide were noted.

Occupational Allergic Contact Dermatitis Disseminated from Multifunctional Acrylates in Ultraviolet-Cured Lacquers

“…Estlander et al [8] reported occupational contact dermatitis from UVcured lacquer for painting wood, containing dipropylene glycol diacrylate (DPGDA). Our patient had dermatitis disseminata; eczema hyperkeratoticum manuum, very frequent in other patients exposed to acrylates, was not observed [3].…”

Risks of Allergic Contact Dermatitis Elicited by Nickel, Chromium, and Organic Sensitizers: Quantitative Models Based on Clinical Patch Test Data

“…Patch tests done on 11 patients sensitive to HEMA showed five positive reactions (i.e., a response rate of 5/11, or 45.5%) at a 0.02% (6.3 μg/cm 2 ) HEMA level—significantly greater than the 158/1,236 (12.8%) rate observed in all patients sensitive or exposed to one or more (meth)acrylates excluding HEMA ( p = 0.015, by Fisher's exact test).…”

“…Ni and Cr patch test data pertain to patients who previously tested positive to Ni and to Cr(VI), respectively. Isobornyl acrylate (not listed) was noted to elicit ACD in one case study but did not do so in any of a total of 153 patch tested patients and is not generally designated as a sensitizer . For each sensitizer X with a listed numeric load L , relative potency ϕ X = GM Ni /GM X based on lognormal ACDER model parameters listed in Table .…”

Clinical update on contact allergy

“…1,6-hexanediol or 1,4-butanediol diglycidyl ethers and phenyl or butyl glycidyl ethers) [81 ]. Epidemics of ACD suggest new allergens, or faulty workplace hygiene, as in the case of nine out of 81 workers manufacturing electric coils, who were sensitized to various acrylates, including triethyleneglycol diacrylate, diethyleneglycol diacrylate, 1,6-hexanediol diacrylate and others [82 ].…”