An Epidemiologic Analysis of End-stage Lupus Nephritis

Iseki, Kunitoshi; Miyasato, Fujihiko; Oura, Takashi; Uehara, Hajime; Nishime, Keizo; Fukiyama, Koshiro

doi:10.1016/s0272-6386(12)80377-5

Cited by 75 publications

(49 citation statements)

References 32 publications

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“…We obtained the collaboration of the Okinawa Medical Association and other main hospitals in Okinawa. The number of strokes in the present study might be a little lower than the actual number of strokes, but these medical facilities covered more than 95% of the cases of systemic lupus erythematosus in the same entire area of Okinawa, 21 and in the COSMO study, 63 death certificates relating to stroke were identified in the designated city and 61 of them (96.8%) had also been registered. 12 Moreover, the incidence of stroke reported in this study is not lower than that of other reports from Japan, 20,22 so we think this possibility is negligible.…”

Section: Study Limitationsmentioning

confidence: 58%

Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men

et al. 1999

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Section: Study Limitationsmentioning

confidence: 58%

Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men

et al. 1999

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“…However, there are scant recent data on the incidence rates of SLE in adult populations in Asia. Iseki et al [17] demonstrated that the crude incidence of SLE in Okinawa from 1972 to 1991 was 0.9 to 2.9 per 100,000 by hospital and clinical-based studies. In the present study, the incidence rate of SLE was around 3-6 per 100,000 from 2000 to 2008.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis as a risk factor for systemic lupus erythematosus: results of a nationwide study in Taiwan

et al. 2011

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A previous study, with relatively small number of patients, showed that prior Mycobacterium tuberculosis (TB) may precipitate SLE in patients from endemic areas. The purpose of the study was to investigate the relationship between prior TB infection and systemic lupus erythematosus (SLE) from the National Health Insurance Research Database (NHIRD) in Taiwan. Cases of SLE and TB were identified from the NHIRD with corresponding ICD-9 codes 710.0 and 011-018, respectively, from January 2000 to December 2008. A total of 2,721 cases of SLE and 10,823 control subjects were included in data analysis. The average annual incidence rate was 8.1 per 100,000. The annual incidence rates of SLE decreased from 6.38 per 100,000 to 2.55 per 100,000 during 2000-2008. Compared with the control subjects, SLE patients were more likely to be white collar workers (P = 0.0005), reside in highly urbanized areas (P = 0.0140), and have higher incomes (P = 0.0088). TB was much more prevalent in SLE patients than in the control subjects (1.8 vs. 0.9%, P < 0.001). The mean time interval between diagnosis of TB and SLE was 45.58 ± 39.0 months. On multivariate analysis, TB was the greatest potential risk factor for precipitating SLE (OR = 2.11, 95% CI = 1.49-3.00). In addition, patients with co-existing TB and DM had a higher risk of SLE than the control group (OR = 3.91, 95% CI 1.84-8.31). In conclusion, this study suggests that there is an increased risk of precipitating SLE among patients with TB in Taiwan from a nationwide health insurance research dataset. Mycobacterial infections could trigger autoimmune diseases in experimental studies. Furthermore, a study with relatively small number of patients revealed that prior TB may precipitate SLE in patients from endemic areas. There is an increased risk of precipitating SLE among patients with TB in Taiwan from a nationwide health insurance research dataset during a 9-year period.

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“…For this purpose, we sought the cooperation of all of the dialysis units (n = 31) and other hospitals and clinics in Okinawa. We estimated that the medical facilities surveyed covered about 95% of the entire patient population at risk [19]. The medical records were examined to document timing and method of DM diagnosis.…”

Section: Methodsmentioning

confidence: 99%

Epidemiologic Analysis of Diabetic Patients on Chronic Dialysis

Saito¹,

Iseki²,

Nishime³

et al. 1996

Nephron

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We retrospectively surveyed all of the available medical records of 404 (191 females and 213 males) chronic dialysis patients, of whom 16 (4%) had insulin-dependent diabetes mellitus (IDDM) and 388 (96%) non-insulin-dependent diabetes mellitus (NIDDM). The patients were among 2,214 dialysis patients in Okinawa, Japan, of whom 443 were diabetic. The patients entered a large population-based dialysis registry. The mean duration from the diagnosis of diabetes mellitus (DM) to dialysis was 181.6 months in the IDDM patients and 150.4 months in the NIDDM patients. The NIDDM patients were classified into four subgroups according to their status when DM was first suspected. The duration from the diagnosis of DM until the onset of dialysis treatment was significantly shorter than in any other subgroup or in the IDDM subgroup with major vascular disease (131.9 months). Otherwise, the course of renal disease in NIDDM patients was similar to that in IDDM individuals. Most of our dialysis patients with DM had NIDDM. In most of the NIDDM patients, the diagnosis had been delayed for several years for unknown reason. However, if diagnosed early, NIDDM shows a clinical time course until dialysis similar to that of IDDM. Whether NIDDM patients contract chronic renal disease at an equal incidence to that of IDDM patients and the fraction of all diabetic patients accepted for chronic dialysis remain to be determined.

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An Epidemiologic Analysis of End-stage Lupus Nephritis

Cited by 75 publications

References 32 publications

Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men

Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men

Tuberculosis as a risk factor for systemic lupus erythematosus: results of a nationwide study in Taiwan

Epidemiologic Analysis of Diabetic Patients on Chronic Dialysis

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