An Epidemiologic Study on Hosts and Pathogens of Urinary Tract Infection in Urban Children of Korea (2012–2017)

Abstract

Purpose: We aimed to determine characteristics of host, causative organisms, and antibiotic susceptibility of bacteria in pediatric patients with UTI living in metropolitan area of Korea. Methods: Retrospective investigation was done for the causative organisms of UTI in 683 pediatric cases treated at Ajou University Hospital from 2012 to 2017. Patients were classified into Escherichia coli and nonE. coli group, where E. coli group was subdivided into ESBL(+) and ESBL(-) groups based on whether the bacteria could produce extended spectrum beta-lactamase (ESBL). Antibiotic susceptibility of the causative organism was also determined. Results: A total of 683 UTIs occurred in 550 patients, of which 463 (67.8%) were first-time infection and 87 (32.2%) were recurrent ones (2-7 recurrences, 2.52 average), and 64.9% were male and 35.1% were female. The most common causative organism was E. coli (77.2%) and ESBL(+) E. coli was found in 126 cases. The susceptibility of E. coli to 3rd or 4th generation cephalosporin was relatively higher than that to ampicillin or amoxicillin/clavulanic acid. ESBL(+) E. coli showed higher resistance rate to 3rd or 4th generation cephalosporin than ESBL(-) E. coli. Conclusion: New treatment guideline should be considered due to the incidence of ESBL(+) E. coli increased up to one quarter of UTI cases.

Current status of long-term antibiotic prophylaxis for urinary tract infections in children: An antibiotic stewardship challenge

“…However, the antibiotic susceptibility pattern for UTIs across different geographic locations is slightly different. In Asia, studies of children with confirmed UTIs reported an ampicillin resistance rate of 66% to 82%, whereas TMP-SMX resistance was 50% to 62% [31,36,40–42]. In the United States, most samples collected from children with suspected/confirmed UTI were sensitive to a first-generation cephalosporin, amoxicillin-clavulanate, and nitrofurantoin [43,44].…”

Effects of urinary tract infection during the first years of life in subsequent growth: a nationwide comparative matched cohort study

“…Urinary tract infection (UTI) is among the most common bacterial infections in children ( 1 , 2 ). The prevalence of UTIs is approximately 7.0% in febrile infants aged <24 months and 8% in older children ( 3 ).…”

Impact of early-life weight status on urinary tract infections in children: a nationwide population-based study in Korea

“…UTIs are among the most common causes of acute illness in childhood [ 7 , 8 ]. More than 1 million children with UTIs visit clinicians annually in the United States, and approximately 50,000 children with UTIs are admitted per year, with inpatient costs > US$180 million [ 9 , 10 ].…”