An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus

Pipelzadeh, Mohammad Hassan; Jalali, Amir; Taraz, Mohammad; Pourabbas, Roya; Zare-Mirakabadi, Abbas

doi:10.1016/j.toxicon.2007.07.018

Cited by 143 publications

(123 citation statements)

References 20 publications

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“…Iranian scorpions belong predominantly to the Buthidae and Scorpionidae families and the most common species are: Mesobuthus eupeus, Odontobuthus doriae, Scorpio maurus, and Hemiscorpius lepturus. M. eupeus, of the Buthidae family, is the most frequent scorpion species in the country (1)(2)(3)(4)(5). Its venom may provoke several symptoms from pain, inflammation and muscle paralysis to death in children.…”

Section: Introductionmentioning

confidence: 99%

Comparison of two purified toxic fractions from Mesobuthus eupeus scorpion venom

Shirmardi¹,

Shamsaei²,

Ghanei³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:Iranian scorpions belong mainly to the Buthidae and Scorpionidae families, distributed into 16 genera and 25 species. In Iran, similar to other parts of the world, there are a few known species of scorpions responsible for severe envenoming; amongst which Mesobuthus eupeus is the most common. Its venom contains several toxin fractions that may affect the ion channel. In the present study purification, labeling and biological evaluation of M. eupeus venom are described. For separation, soluble venom was loaded on a chromatography column packed with Sephadex G-50 gel. Subsequently, the fractions were collected according to UV absorption at a wavelength of 280 nm. Toxic fraction (F3) was loaded on an anionic ion exchanger resin and then on a cationic resin. Finally, toxic subfractions F3.1.6 and F3.1.9 were labeled with 99m Tc and injected into normal mice to distinguish excretion pathway. The venom toxic fraction was successfully obtained in its purified form. Radiolabeling of toxic fractions was performed at high specific activity with radiochemical purity of more than 97 and 95% respectively for F3.1.6 and F3.1.9. Biodistribution studies in normal mice with two toxic fractions usually show rapid clearance of the compounds from blood and tissue except for kidneys. Since tissue distribution studies are very important for clinical purpose, the present findings suggest that 99m Tc labeling of venom is a useful tool for in vivo studies and comprises an excellent approach to monitoring the process of biodistribution and kinetics of toxins.

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Section: Introductionmentioning

confidence: 99%

Comparison of two purified toxic fractions from Mesobuthus eupeus scorpion venom

Shirmardi¹,

Shamsaei²,

Ghanei³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Delayed localised necrosis has been reported in patients stung by an Iranian scorpion (Hemiscorpius lepturus). 31 Patients with envenomation from the thick-tailed scorpion (Parabuthus transvaalicus) in Zimbabwe have been reported to develop predominant symptoms from parasympathetic nerve system stimulation, including profuse sialorrhoea, sweating, and urinary retention, in the absence of sympathetic stimulation. 32 Scorpion stings and envenomation are uncommon in Hong Kong.…”

Section: Discussionmentioning

confidence: 99%

Injuries and envenomation by exotic pets in Hong Kong

Lit²,

Wong³

et al. 2018

Hong Kong Med J

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“…From April 1990 to July 1996, 36,463 scorpion stings were referred to the scorpion sting clinic at Abuzar Hospital, Ahwaz, Iran, and a mean of 5610 per year with 61 deaths reported 34 . Recently, PIPELZADEH et al, reported that HL was responsible for 89% of the deaths and 92% of hospitalized scorpion-stung patients from the same region 31 . In another study from Kashan, a city in central of Iran by DEHGHANI et al, reported that 30% of the cases were stung by the black scorpion Androctonus crassicauda, 62% by the yellow scorpions Mesobothus eupeus and liivierus caucasicus and 8% were stung by unidentified species of scorpions 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the epidemiological aspects of scorpionism, the majority of studied cases in Iran, were children aged less than 12 years old 31 . In the neighboring country, Turkey, 54.1% of the patients were adolescents 1 .…”

Section: Discussionmentioning

confidence: 99%

Asymmetric pulmonary edema after scorpion sting: a case report

Razi

Malekanrad

2008

Rev. Inst. Med. trop. S. Paulo

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SUMMaRYA 12-year-old boy was referred with acute asymmetric pulmonary edema (APE) four-hour after scorpion sting to Emergency department. On admission, the main clinical manifestations were: dyspnea, tachypnea, and tachycardia. Chest x-ray revealed APE predominantly on the right hemithorax. The patient was treated with oxygen, intravenous frusemide and digoxin and discharged on the sixth hospital day in a good condition. This case report emphasizes the occurrence of asymmetric pulmonary edema after severe scorpion envenomation within few hours immediately after the sting.

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An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus

Cited by 143 publications

References 20 publications

Comparison of two purified toxic fractions from Mesobuthus eupeus scorpion venom

Comparison of two purified toxic fractions from Mesobuthus eupeus scorpion venom

Injuries and envenomation by exotic pets in Hong Kong

Asymmetric pulmonary edema after scorpion sting: a case report

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