An epidemiological approach to elucidate dopaminergic mechanisms in tardive dyskinesia in schizophrenia

Tenback, Diederik E.

doi:10.26481/dis.20061025dt

Cited by 1 publication

(1 citation statement)

References 77 publications

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“…13 MD can be induced by antipsychotics, but also reflect a fundamental aspect of neurodevelopmental pathophysiology involving the sensitization of dopaminergic nigrostriatal circuits. 14 Several authors studied a possible link between TD and mortality. Some found higher mortality rates in SMI patients with TD than in those without TD 11,12,[15][16][17] but others reported negative findings.…”

Section: Introductionmentioning

confidence: 99%

Movement Disorders and Mortality in Severely Mentally Ill Patients: The Curacao Extrapyramidal Syndromes Study XIV

Willems,

Mentzel,

Bakker

et al. 2022

Schizophrenia Bulletin

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Background and Hypothesis There is a substantial gap in life expectancy between patients with severe mental illness (SMI) and the general population and it is important to understand which factors contribute to this difference. Research suggests an association between tardive dyskinesia (TD) and mortality; however, results are inconclusive. In addition, studies investigating associations between parkinsonism or akathisia and mortality are rare. We hypothesized that TD would be a risk factor for mortality in patients with SMI. Study Design We studied a cohort of 157 patients diagnosed predominantly with schizophrenia on the former Netherlands Antilles. TD, parkinsonism, and akathisia were assessed with rating scales on eight occasions over a period of 18 years. Twenty-four years after baseline, survival status and if applicable date of death were determined. Associations between movement disorders and survival were analyzed using Cox regression. Sex, age, antipsychotics, antidepressants and benzodiazepines at each measurement occasion were tested as covariates. Study Results Parkinsonism was a significant risk factor with an HR of 1.02 per point on the motor subscale of the Unified Parkinson’s Disease Rating Scale (range 0–56). TD and akathisia were not significantly associated with mortality. Conclusions Parkinsonism may be an important risk factor for mortality in SMI patients. This finding calls for more follow-up and intervention studies to confirm this finding and to explore whether treatment or prevention of parkinsonism can reduce excess mortality.

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Section: Introductionmentioning

confidence: 99%

Movement Disorders and Mortality in Severely Mentally Ill Patients: The Curacao Extrapyramidal Syndromes Study XIV

Willems,

Mentzel,

Bakker

et al. 2022

Schizophrenia Bulletin

View full text Add to dashboard Cite

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An epidemiological approach to elucidate dopaminergic mechanisms in tardive dyskinesia in schizophrenia

Abstract: PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit Maastricht, op gezag van de Rector Magnificus, Prof. mr. G.P.M.F. Mols, volgens het besluit van het College van Decanen, in het openbaar te verdedigen op woensdag 25 oktober 2006 om 12.00 uur.

Cited by 1 publication

References 77 publications

Movement Disorders and Mortality in Severely Mentally Ill Patients: The Curacao Extrapyramidal Syndromes Study XIV

Movement Disorders and Mortality in Severely Mentally Ill Patients: The Curacao Extrapyramidal Syndromes Study XIV

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