An epidemiological study of neuromyelitis optica in Cuba

Cabrera-Gómez, José Antonio; Kurtzke, John F.; González‐Quevedo, Alina; Lara-Rodríguez, Ruth

doi:10.1007/s00415-009-0009-0

Cited by 164 publications

(147 citation statements)

References 39 publications

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“…The hamstring and gluteal muscle weakness can lead to lower interstitial and imbalance syndrome; this imbalance can have harmful effects on the static and dynamic status of the body, especially when walking. This syndrome increases the anterior pelvic tilt and in the spine increases lumbar lordosis and a small hip flexion (1,11) It is reported that that MS patients suffer from postural and physical impairment, they cannot directly maintain their postures, which, as a result of this defect, disabilities are increased in posture and spinal column (9). There are little research on spinal cord abnormalities in MS patients and healthy partners.…”

Section: Discussionmentioning

confidence: 99%

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Spinal Cord Analysis in People with Multiple Sclerosis

Meymand

Daneshmandi

Al-Zamani

et al. 2018

Ann. Appl. Sport Sci

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Background. Multiple Sclerosis (MS) is an autoimmune, inflammatory, and chronic disease which, under the effect of the wastes of myelin degradation occurs in the white matter of the brain, spinal cord, and visual nerves. The main complications of this disease are fatigue, muscle cramps, tremor, imbalance, and walking imbalance. Objectives. The purpose of this study is to investigate the spine orientation in people with multiple sclerosis. Methods. The statistical population of this study included all patients with MS in Kerman province and the sample of this study includes 30 patients with mild MS (mean age of 33.83±8.72 years, mean height of 159.77±4.54 cm, mean weight of 63.1±11.16 kg) and 30 healthy subjects (mean age of 31.07±8.84 years, mean height of 162.58±6.61 cm, mean weight of 61.43±11.3 kg), targeted randomly selected as the subjects. First, the patients were examined by a neurologist and the EDSS of each subject was evaluated. Then their demographic data including age, height, and weight were collected. For evaluation of spinal abnormalities including torticollis and forward head, shooting method with the use of -Power shot A1200 HD Canon camera, with 0.73 validity was used; and kyphosis and lordosis abnormalities were measured using a flexible ruler, the validity of the device in comparison with the radiography technique was reported by Thylatson and Borton (1991) as 93%. In research, Hart & Rose (1986) and Lowell et al. (1989) stated the reliability of this device as 97% and 84%, respectively, and scoliometer was used for scoliosis abnormalities. The validity of this device was reported by Guillemhem et al. as 0.87. Results. The results showed that there was a significant relationship between forward head, torticollis, and lordosis abnormalities in patients with mild MS and healthy subjects (p˂0.05), while there is significant relationship between kyphosis and scoliosis (p˂0.05). Conclusion. Regarding factors such as fatigue, muscle cramping, tremor, walking abnormalities in people with multiple sclerosis and observation of some spinal abnormalities in these individuals, the implementation of corrective exercises and programs to correct postures, in them, seems necessary.

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Section: Discussionmentioning

confidence: 99%

“…Today, in terms of epidemiology, noncommunicable diseases are responsible for 60% of the world's death and mortality cases (1). Among these diseases, diabetes, asthma, multiple sclerosis etc.…”

Section: Introductionmentioning

confidence: 99%

Spinal Cord Analysis in People with Multiple Sclerosis

Meymand

Daneshmandi

Al-Zamani

et al. 2018

Ann. Appl. Sport Sci

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“…[1][2][3][4] NMO is a B-cell-mediated inflammatory and demyelinating disorder of the central nervous system, often presenting with severe and bilateral recurrent optic neuritis and transverse myelitis that are radiological distinguished from multiple sclerosis (MS). 5,6 Early detection of NMO is facilitated by the testing for the neuromyelitis optica immunoglobulin G (NMO-IgG) antibody.…”

Section: Case Reportmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorder in a Chinese Woman with Ocular Myasthenia Gravis: First Reported Case in the Chinese Population

Yau

Lee

Chan

et al. 2014

Neuro-Ophthalmology

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Coexisting myasthenia gravis and neuromyelitis optica spectrum disorder was reported as a rare association, with only 26 reported cases in the literature. The authors report the case of a middle-aged Chinese woman with bilateral recurrent optic neuritis and seropositive ocular myasthenia gravis who was subsequently diagnosed with neuromyelitis optica spectrum. She was tested seropositive for the neuromyelitis optica immunoglobulin G (NMO-IgG) and had elevated antinuclear antibody titres, but workup for other autoimmune disorders were negative. She was subsequently prescribed with azathioprine and pyridostigmine, and showed good control of both autoimmune disorders. To the best of the authors' knowledge, this is the first reported case in the literature of a Chinese patient with seropositivity for both anti-acetylcholine receptor and NMO-IgG without a thymic disorder. Testing of NMO-IgG may be considered in patients with optic neuritis with underlying autoimmune disorders even in the absence of transverse myelitis for the detection of associated neuromyelitis optica spectrum disorders.

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Section: Neuromyelitis Opticamentioning

confidence: 99%

“…NMO is rare and accounts for only 1% of all demyelinating diseases [26][27][28]. The incidence of NMO is estimated to be approximately 4 per million of the population and the prevalence is somewhere between 3 and 44 per million, depending on ethnicity and geographic location [26][27][28][29]. Disease onset is usually in the fourth decade of life; women are affected more commonly than men (approximately 3:1); and non-Caucasians (especially Japanese) are affected more commonly than Caucasians [29][30][31][32].…”

Section: Neuromyelitis Opticamentioning

confidence: 99%

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Geldern¹,

McPharlin

Becker

2012

Neurotherapeutics

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This chapter will review the spectrum of immunemediated diseases that affect the nervous system and may result in an admission to the neurological intensive care unit. Immunomodulatory strategies to treat acute exacerbations of neurological diseases caused by aberrant immune responses are discussed, but strategies for long-term immunosuppression are not presented. The recommendations for therapeutic intervention are based on a synthesis of the literature, and include recommendations by the Cochrane Collaborative, the American Academy of Neurology, and other key organizations. References from recent publications are provided for the disorders and therapies in which randomized clinical trials and large evidenced-based reviews do not exist. The chapter concludes with a brief review of the mechanisms of action, dosing, and side effects of commonly used immunosuppressive strategies in the neurocritical care unit.

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An epidemiological study of neuromyelitis optica in Cuba

Abstract: This Cuban multiethnic population had a prevalence of NMO of 0.52 per 100,000 and an estimated average annual incidence rate of 0.053 per 100,000 with no differences by ethnicity. Black patients were older, with more relapses and motor impairment.

Cited by 164 publications

References 39 publications

Spinal Cord Analysis in People with Multiple Sclerosis

Spinal Cord Analysis in People with Multiple Sclerosis

Neuromyelitis Optica Spectrum Disorder in a Chinese Woman with Ocular Myasthenia Gravis: First Reported Case in the Chinese Population

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

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