An Epidemiological Study on Ankylosing Spondylitis in Southern Albania

Koko, Vjollca; Ndrepepa, Ana; Skenderaj, Skender; Ploumis, Avraam; Backa, Teuta; Tafaj, Argjend

doi:10.5455/msm.2014.26.26-29

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…However, relatively few studies have focused on AS and less have yet specifically examined the effect that smoking has on functional disease activity (BASFI), and the quality of life of patients with d AS. [ 13 - 18 ].…”

Section: Introductionmentioning

confidence: 99%

Axial Spondyloarthritis and Cigarette Smoking

Kaut

abourazzak

Jamila

et al. 2017

TORJ

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Background:Smoking is one of the main environmental risk factors involved in several rheumatic diseases according to ACR 2014, it is included among the risk factors for severe axial spondyloarthritis.Objectives:The objective is to study the association between smoking and the activity of the disease, the functional impact and the severity of the axial spondyloarthritis.Methods:It is a transversal study with a descriptive and analytical aim, during the period between January 2014 and December 2015 conducted in the department of rheumatology at the CHU Hassan II of Fes.The data was recorded and analyzed using SPSS v20 univariate and bivariate analysisA value of p <0.005 has been used to identify factors associated with smoking.Results:The study included 214 patients, 130 men and 84 women. The mean age was 39.77 ± 13.06 (16-68) years with an average disease duration of 7.97 ± 6.4 (2-35) years.The prevalence of smoking in patients with spondyloarthritis was 36%.According to the univariate and bivariate analysis: Smoking was associated with the male sex (p≤0.0001), with a functional impairment BASFI (p = 0.038) and activity BASDAI (p=0.004) and ASDAS CRP, (p=0.036).Multivariate logistic regression analysis suggested that smoking was associated with male sex and the severity of the disease.Conclusion:Our study suggests that there is a significant association between smoking and male sex and the severity of the disease.

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Section: Introductionmentioning

confidence: 99%

Axial Spondyloarthritis and Cigarette Smoking

Kaut

abourazzak

Jamila

et al. 2017

TORJ

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“…47 studies were of AS (including 32 using modi ed New York criteria) and 17 of axSpA (including 11 using the ASAS criteria). Delay ranged from 2.8 years in a small Albanian study (of 54 cases over 6 years), to 11.1 years in a single UK centre [13,14]. The mean delay to diagnosis was 6.7 years overall (95% con dence interval 6.2 to 7.2, I 2 =99%).…”

Section: Diagnostic Delay In Axspamentioning

confidence: 93%

Systematic review and meta-analysis of diagnostic delay in axial spondyloarthritis

Zhao

Pittam

Harrison

et al. 2020

Preprint

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Background. Delay to diagnosis in axial spondyloarthritis (axSpA) is longer than many other rheumatic diseases. Prolonged delay has been shown to associate with poorer outcomes including functional impairment and quality of life. Our aims were to describe 1) global variation in delay to diagnosis, 2) factors associated with delay, and 3) differences in diagnostic delay between axSpA and psoriatic arthritis (PsA).Methods. We searched Medline, PubMed, EMBASE and Web of Science using a predefined protocol in accordance with PRISMA guidelines. Delay to diagnosis was defined as years between age at symptom onset and age at diagnosis. We pooled mean diagnostic delay using random-effects inverse variance meta-analysis. We examined variations in pooled estimates using pre-specified subgroup analyses and sources of heterogeneity using meta-regression.Results. A total of 64 studies reported mean diagnostic delay in axSpA patients. The pooled mean delay was 6.7 years (95% confidence interval 6.2 to 7.2) with high levels of heterogeneity. Delay to diagnosis did not improve over time when stratifying results by year of publication. Studies from high-income countries (defined by the World Bank) reported longer delay than those from middle-income countries. Factors consistently reported to be associated with longer delay were: lower education levels, younger age at symptom onset and absence of extra-articular manifestations. Pooled estimate for diagnostic delay from 8 PsA studies was significantly shorter, at 2.6 years (95%CI 1.6 to 3.6). Conclusion. For axSpA patients, delay to diagnosis remains unacceptably prolonged in many parts of the world, although some countries have reported remarkable improvements. Patient factors (education) and disease presentation (age at onset and extra-articular manifestations) should inform awareness campaigns to improve delay. Targets for improvement should aim to resemble delays in other spondyloarthritis patients.

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“…38 studies were of AS (including 25 using modified New York criteria) and 18 of axSpA (including 11 using the ASAS criteria). Delay ranged from 2.8 years in a small Albanian study (of 54 cases over 6 years), to 11.1 years in a single UK centre [12,13]. The mean delay to diagnosis was 6.8 years overall (95% confidence interval 6.2 to…”

Section: Diagnostic Delay In Axspamentioning

confidence: 94%

Systematic review and meta-analysis of diagnostic delay in axial spondyloarthritis

Zhao¹,

Pittam²,

Harrison³

et al. 2020

Preprint

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Background . Delay to diagnosis in axial spondyloarthritis (axSpA) is longer than many other rheumatic diseases. Prolonged delay has been shown to associate with poorer outcomes including functional impairment and quality of life. Our aims were to describe 1) global variation in delay to diagnosis, 2) factors associated with delay, and 3) differences in diagnostic delay between axSpA and psoriatic arthritis (PsA).Methods . We searched Medline, PubMed, EMBASE and Web of Science using a predefined protocol in accordance with PRISMA guidelines. Delay to diagnosis was defined as years between age at symptom onset and age at diagnosis. We pooled mean diagnostic delay using random-effects inverse variance meta-analysis. We examined variations in pooled estimates using pre-specified subgroup analyses and sources of heterogeneity using meta-regression.Results. A total of 54 studies reported mean diagnostic delay in axSpA patients. The pooled mean delay was 6.8 years (95% confidence interval 6.2 to 7.3) with high levels of heterogeneity. Delay to diagnosis did not improve over time when stratifying results by year of publication. Studies from high-income countries (defined by the World Bank) reported longer delay than those from middle-income countries. Factors consistently reported to be associated with longer delay were: lower education levels, younger age at symptom onset and absence of extra-articular manifestations. Pooled estimate for diagnostic delay from 8 PsA studies was significantly shorter, at 2.6 years (95%CI 1.6 to 3.6).Conclusion. For axSpA patients, delay to diagnosis remains unacceptably prolonged in many parts of the world, although some countries have reported remarkable improvements. Patient factors (education) and disease presentation (age at onset and extra-articular manifestations) should inform awareness campaigns to improve delay. Targets for improvement should aim to resemble delays in other spondyloarthritis patients.

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An Epidemiological Study on Ankylosing Spondylitis in Southern Albania

Cited by 17 publications

References 22 publications

Axial Spondyloarthritis and Cigarette Smoking

Axial Spondyloarthritis and Cigarette Smoking

Systematic review and meta-analysis of diagnostic delay in axial spondyloarthritis

Systematic review and meta-analysis of diagnostic delay in axial spondyloarthritis

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