An Epstein-Barr virus susceptible immature T-cell line, WILL4, established from a patient with T-lymphoblastic lymphoma bearing CD21 and a clonal EBV genome

Composite Epstein-Barr Virus-associated T-lymphoblastic and Peripheral T-cell Lymphomas: A Clonal Study

“…The T-LBL cells were found to be CD21-positive at the initial diagnosis, as reported previously ( 6 ). The CD21 expression of the PTCL-NOS cells was examined in this study because we previously showed that the EBV infection of the T-LBL cells occurred through the CD21 molecule ( 6 ). Immunostaining revealed that the PTCL-NOS cells were CD21-negative ( Fig.…”

“…A 30-year-old Japanese woman was admitted to our hospital with a mediastinal tumor. The clinical course of this case was described previously ( 6 ). In brief, the mediastinal tumor was diagnosed as a T-LBL without bone marrow involvement.…”

“…The cells in the pleural effusion exhibited the same phenotype as those seen in the mediastinal tumor. The T-LBL cells were CD21-positive ( 6 ). At relapse, the EBV-DNA viral load in the patient's peripheral blood was 4×10 2 copies among 1×10 6 white blood cells, indicating that the EBV-DNA viral load in the peripheral blood had not markedly increased since the initial diagnosis.…”