An estimate of the heritable fraction of childhood cancer

Narod, Steven A.; Stiller, Charles; Lenoir, Gilbert

doi:10.1038/bjc.1991.216

Cited by 229 publications

(158 citation statements)

References 43 publications

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“…There have been reports of increased incidence of specific tumours in the UK for neuroblastoma (Stiller, 1993) and leukaemia (Blair and Birch, 1994). The aetiology of childhood cancers remains largely unknown; only about 5% are thought to have an inherited genetic component (Narod et al, 1991). The increasing incidence of childhood cancer is consistent with the hypothesis that environmental factors play a role in the aetiology of these diseases.…”

Section: Childhood Cancermentioning

confidence: 75%

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

et al. 2000

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The Northern Region Young Persons’ Malignant Disease Registry records information on young people under 25 years old diagnosed with cancer in the Northern Region of England. Incidence and survival rates were calculated for children and young adults diagnosed with cancer between 1968 and 1995. There were 2099 (M:F 1.28:1) children (age 0–14 years) and 2217 (M:F 1.23:1) young adults (15–24 years) diagnosed with a first cancer between 1968 and 1995. The age-standardized rate (ASR) for childhood cancer was 121 per million 0 to 14 year-olds per year. For young adults the ASR was 175 per million 15 to 24 year-olds, per year. Incidence of childhood cancer increased over time at a rate of 12 extra cases per million children, per decade ( P < 0.001). In young adults incidence rates increased by 16 extra cases per million 15 to 24 year-olds, per decade ( P < 0.001). For childhood cancer 5-year survival was 42% for those diagnosed 1968–1977, 57% for 1978–1987 and 71% (95% CI 67–75) for 1988–1995. Survival for young adults over the three periods was 45%, 62% and 73% (95% CI 70–78) respectively. The cumulative risk of developing cancer before the age of 25 is 1 in 285. Over the 28-year period there were significant improvements in survival and modest increases in incidence in both children and young adults. © 2000 Cancer Research Campaign

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Section: Childhood Cancermentioning

confidence: 75%

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

et al. 2000

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“…The diagnosis of all cases was reviewed centrally, from biological specimens (33%), pathology or post-mortem reports (18%), clinical records (24%) or case registration information (25%). We excluded: leukaemia and non-Hodgkin's lymphoma; retinoblastoma, as almost half the cases are hereditary (Narod et al, 1991); genderspecific tumours, as the population at risk differs; registrations with an ICD-O morphology code of 1 or 2 indicating non-malignancy. First malignancies were extracted.…”

Section: Ascertainment Of Casesmentioning

confidence: 99%

Childhood solid tumours in relation to infections in the community in Cumbria during pregnancy and around the time of birth

2002

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In a retrospective cohort study of all 99 976 live births in Cumbria, 1975Cumbria, -1992, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for solid tumours (brain/spinal and other tumours), diagnosed 1975 -1993 under age 15 years. Logistic regression was used to relate risk to incidence of community infections in three prenatal and two postnatal quarters. There was an increased risk of brain/spinal tumours among children exposed around or soon after birth to higher levels of community infections, in particular measles (OR for trend=2.1, 95%CI : 1.3 -3.6, P=0.008) and influenza (OR for exposure=3.3, 95%CI : 1.5 -7.4, P=0.005). There was some evidence of an association between exposure to infections around and soon after birth and risk of other tumours, but this may have been a chance finding. The findings are consistent with other recent epidemiological studies suggesting brain tumours may be associated with perinatal exposure to infections.

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“…Brain tumour is a component of certain rare cancer syndromes such as Li-Fraumeni, neurofibromatosis 1 and 2, von Hippel-Lindau and Gorlin (Li, 1995;Fearon, 1997;Huson, 1998). However, these conditions are likely to explain only a small proportion of childhood brain tumours; only 2% based on a review of records (Narod et al, 1991). No increased risk of brain tumour was observed in parents of childhood brain tumour patients (Olsen et al, 1995), though among offspring of survivors of childhood brain tumours the relative risk was 2.0 and almost significant (Sankila et al, 1998).…”

mentioning

confidence: 99%

Cancers in the first-degree relatives of children with brain tumours

Hemminki

Vaittinen

et al. 2000

Br J Cancer

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We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958–1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61. © 2000 Cancer Research Campaign

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An estimate of the heritable fraction of childhood cancer

Cited by 229 publications

References 43 publications

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

Childhood solid tumours in relation to infections in the community in Cumbria during pregnancy and around the time of birth

Cancers in the first-degree relatives of children with brain tumours

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