An estimation of serum malondialdehyde, superoxide dismutase and vitamin A in oral submucous fibrosis and its clinicopathologic correlation

Metkari, Suryakant B; Tupkari, JV; Barpande, SR

doi:10.4103/0973-029x.33960

Cited by 22 publications

(21 citation statements)

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“…The significant increase in serum levels of MDA in precancer (p = 0.470) as compared to control was in agreement with previous studies [40,41]]. Although previous studies have reported a decrease in levels of various antioxidants in oral precancer [43,44], literature search has revealed that the TAC level has so far not been measured in oral precancer. This is the first study to carry out the investigation which is important so as to better understand the possible mechanisms in carcinogenesis.…”

Section: Discussionsupporting

confidence: 80%

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Korde¹,

Basak

Chaudhary³

et al. 2011

Oncology

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Objective: Interaction between reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a crucial determinant in the etiology of oral squamous cell carcinoma (OSCC), and antioxidants protect against cellular and molecular damage caused by these. This study aims to evaluate ROS and RNS, together with the total antioxidant capacity (TAC), in serum and tissues of OSCC patients. Method: Total nitric oxide (TNO), malondialdehyde (MDA), and TAC were evaluated using a UV visible spectrophotometer in the serum of 30 controls, 30 precancer and 30 OSCC patients and in tissues of 10 controls and 30 OSCC patients. Results: MDA and TNO were significantly elevated with concomitant depletion of TAC in serum and tissues of OSCC patients when compared to controls. A significant positive correlation (p = 0.01), at different levels between TNO and MDA in OSCC patients, was found, which increased with the grade of OSCC. Conclusion: An increase in the levels of TNO, NO-mediated lipid peroxidation, resulting in an increase in MDA levels, the positive TNO-MDA correlation with a deranged antioxidant defense system as demonstrated by significantly low levels of TAC; when all these facts are taken together, we can conjecture that oxidative DNA damage, a vital phenomenon for carcinogenesis, occurs due to the interplay of ROS, RNS and TAC.

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Section: Discussionsupporting

confidence: 80%

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Korde¹,

Basak

Chaudhary³

et al. 2011

Oncology

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“…[ 14 ] Literature in the past states that there is a gradual reduction in the SOD level which had a positive correlation with clinical grades of oral submucous fibrosis. [ 15 ] Mean hemolysate levels of both the antioxidant enzymes SOD and GPX were decreased in the patients of oral submucous fibrosis compared to control healthy volunteers. [ 16 ]…”

Section: Discussionmentioning

confidence: 99%

Enzymatic antioxidants and its role in oral diseases

et al. 2015

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Antioxidants are substances that when present at very low concentration inhibits the oxidation of a molecule. It has the capacity to nullify the ill effects of oxidation caused by free radicals in the living organisms. The unpaired electrons of these free radicals are highly reactive and neutralize the harmful reactions of human metabolism. Protection of the body against free radicals is provided by some enzymes which come under a distinctive group, concerned solely with the detoxification of these radicals. Superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase are the key enzymatic antioxidants of this defense system by which the free radicals that are produced during metabolic reactions are removed. This review highlights the mechanism of action of enzymatic antioxidants SOD, GPX and catalase and its role in oral disease.

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“…noticed that superoxide dismutase and Vitamin A levels were reduced in OSMF as compared to controls. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress in the pathogenesis of oral submucous fibrosis: A preliminary prospective study

2015

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Background:In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF.Aims:Is to evaluate both antioxidant and oxidant status in OSMF and to compare with controls.Settings and Design:Twenty patients and 20 controls of the same age group were enrolled in the study.Subjects and Methods:Five milliliters of blood were collected from each individual and serum was separated. Malondialdehyde (MDA) estimation using thiobarbituric acid (TBA) method, and antioxidant activity (AOA) using principle of TBA reactive substances was done using this serum, with a calorimetric method.Statistical Analysis Used:Student's t-test and ANOVA test.Results:The mean serum AOA status was seen to significantly decrease in OSMF patients, as compared to controls (P = 0.013). The increase in mean serum MDA level was highly significant in OSMF patients, as compared to controls (P < 0.001).Conclusion:The disparity between AOA and MDA levels in the patients clearly demonstrates the role of oxidative stress in the disease process. The results also suggest the use of antioxidants in the management of OSMF.

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An estimation of serum malondialdehyde, superoxide dismutase and vitamin A in oral submucous fibrosis and its clinicopathologic correlation

Cited by 22 publications

References 0 publications

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Enzymatic antioxidants and its role in oral diseases

Role of oxidative stress in the pathogenesis of oral submucous fibrosis: A preliminary prospective study

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