An estimation of the number of cells in the human body

Bianconi, Eva; Piovesan, Allison; Facchin, Federica; Beraudi, Alina; Casadei, Raffaella; Frabetti, Flavia; Vitale, Lorenza; Pelleri, Maria Chiara; Tassani, Simone; Piva, Francesco; Pérez‐Amodio, Soledad; Strippoli, Pierluigi; Canaider, Silvia

doi:10.3109/03014460.2013.807878

Cited by 804 publications

(512 citation statements)

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“…Third, storage of fats in LDs potentially provides a significant systemic buffer against fat overload. There are an estimated 1 to 3 trillion ECs in the human body, permeating nearly every organ, with an estimated total volume on the order of 1 L. 7,8 The interface between ECs and plasma is between 4000 and 7000 m 2 , equivalent to the surface of >20 tennis courts.…”

Section: Circulation Researchmentioning

confidence: 99%

Does Endothelium Buffer Fat?

Ibrahim

Arany

2017

Circulation Research

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Section: Circulation Researchmentioning

confidence: 99%

Does Endothelium Buffer Fat?

Ibrahim

Arany

2017

Circulation Research

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“…These settings can be divided into five components ( Figure 2): geodiversity; biodiversity; weather and climate diversity; waterscape diversity; and biomechanical exposure diversity. Besides the relevant human-nature interactions, theories from the environmental psychology perspective, such as somatic interactions with nature, should also be taken into account in order to help to meet the physiological and biomechanical needs of more than 37 trillion individual and identifiable cells that ultimately define the structure and functions of an adult human body [64]. These types of interactions imply physical activity levels that most closely approximate the Paleolithic standard, for which our genetic makeup was originally selected [65].…”

Section: Ecosystem's Health Potential (Ehp)mentioning

confidence: 99%

An Emerging Paradigm for the UNESCO Global Geoparks: The Ecosystem’s Health Provision

et al. 2018

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During the 38th General Conference of UNESCO, the Member States ratified the creation of the International Geoscience and Geoparks Programme (IGGP) expressing governmental recognition of the importance of managing outstanding geological sites and landscapes in a holistic manner. In this context, the importance of human interactions with the natural environment to promote healthy lifestyles was primarily a response to the need to preserve and enhance the value of the UNESCO Global Geoparks as well as highlighting their usefulness for the sustainable development of local populations. The aim of this paper is to suggest an interdisciplinary approach to be applied to UNESCO Global Geoparks for a standardized survey and grading methodology that can be used to assess the ability to provide and promote healthy lifestyles, which is called the Ecosystem’s Health Provision Spectrum (EHPS) on an ecological scale. The suggested EHPS is in line with UNESCO’s priorities, in particular with the IGGP and its motto of “Geosciences in the Service of Society”. Therefore, the EHPS on an ecological scale will be another important tool for the UNESCO Global Geoparks, facilitating efficient management and promoting economic development, wellbeing and health.

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“…Osteocytes are the most abundant cells in bone (1)(2)(3), and they are actively involved in the orchestration of both bone-forming osteoblasts and bone-resorbing osteoclasts (4,5). Osteocytes implement their role by activating the signaling pathways involved in the maintenance of bone homeostasis, specifically the Wnt/β-catenin pathway (6).…”

Section: Introductionmentioning

confidence: 99%

Hypoxia mediates osteocyte ORP150 expression and cell death in vitro

Montesi

Jähn

Bonewald

et al. 2016

Molecular Medicine Reports

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Abstract. Skeletal unloading leads to hypoxia in the bone microenvironment, resulting in imbalanced bone remodeling that favors bone resorption. Osteocytes, the mechanosensors of bone, have been demonstrated to orchestrate bone homeostasis. Hypoxic osteocytes either undergo apoptosis or actively stimulate osteoclasts to remove bone matrix during hypoxia. Oxygen-regulated protein 150 (ORP150) is an endoplasmic reticulum-associated chaperone that has been observed to serve an important role in the cellular adaptation to hypoxia and in preventing cellular apoptosis in various tissue types. The current study hypotheses that expression of ORP150 would be increased in osteocytes under hypoxic conditions (1% O 2 ). The MLO-Y4 osteocyte cell line was cultured under normoxic or hypoxic conditions for up to 72 h. It was demonstrated that 1% O 2 significantly induced hypoxia after 16 h and up to 72 h, significantly reduced cell number at 8 and 48 h, induced cell death at 8, 24 and 48 h and induced apoptosis at 16, 24 and 48 h. Significant differences in ORP150 mRNA were observed at 72 h, however no differences were observed in the protein expression levels. The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygen-deprived conditions.

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An estimation of the number of cells in the human body

Abstract: Knowing the total cell number of the human body as well as of individual organs is important from a cultural, biological, medical and comparative modelling point of view. The presented cell count could be a starting point for a common effort to complete the total calculation.

Cited by 804 publications

References 65 publications

Does Endothelium Buffer Fat?

Does Endothelium Buffer Fat?

An Emerging Paradigm for the UNESCO Global Geoparks: The Ecosystem’s Health Provision

Hypoxia mediates osteocyte ORP150 expression and cell death in vitro

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