An ethanol extract of <i>Ramulus mori</i> improves blood circulation by inhibiting platelet aggregation

Lee, Jiyun; Kwon, Gayeung; Park, Jieun; Kim, Jeong Keun; Choe, Soo Young; Seo, Yoonhee; Lim, Young Hee

doi:10.1080/09168451.2016.1156479

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…The TFG D3 group -administered Saputri and Nityasa the highest dose -showed the highest survival rate (80%). Mice treated with a higher dose of TFG extract showed higher survival rates, which is consistent with a previous study showing that aqueous TFG extract inhibited coagulation in a dose-dependent manner [14].…”

Section: Survival Ratesupporting

confidence: 92%

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Saputri

Nityasa

2018

Int J App Pharm

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Objective: This study aimed to further investigate the antiplatelet and antithrombotic activities of Trigonella foenum-graceum (TFG) in vivo.Methods: Male mice were divided into two experimental groups (bleeding duration and survival rate). The study groups comprised vehicle controls(administered carboxymethyl cellulose [CMC]), negative controls (administered CMC), positive controls (administered aspirin), and experimentaltreatment groups (administered TFG extract at three doses). Bleeding duration was assessed by excising the tail vein. Survival rate was determinedby inducing thrombosis through intravenous collagen/epinephrine administration.Results: In mice treated with TFG extract for 7 days, bleeding duration was significantly increased compared with that in controls (p<0.05). Moreover,mice treated with TFG showed increased survival rates compared with negative controls.Conclusion: TFG extract showed antithrombotic activity in mice by significantly increasing bleeding duration and survival rate.

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Section: Survival Ratesupporting

confidence: 92%

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Saputri

Nityasa

2018

Int J App Pharm

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“…A similar result was also found in the previous study, which showed that the bleeding time of Ramulus mori extract at dose 2 was lower than the dose 1. 18 According to the results of this experiment, the highest bleeding time prolongation of K. galanga and C. xanthorrhiza extracts was achieved at dose 3 (28 mg/20 g BW). Antithrombotic activity of K. galanga and C. xanthorrhiza extracts had similarities with aspirin.…”

Section: Discussionmentioning

confidence: 75%

Antithrombotic Effect of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. on Collagen-epinephrine Induced Thromboembolism In Mice

Saputri¹,

Avatara

2018

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Thrombosis is the formation of blood clots both in arteries or veins, which can be caused by platelet aggregation. It is the risk factor of cardiovascular disease. Thrombosis may cause venous thromboembolism (VTE). 1,2 The most serious complication of VTE is pulmonary embolism (PE), which occurs in more than a one-third of VTE patients and contributing to 12% of patient deaths. 3-5 Aspirin is one of the drugs which can inhibit platelet aggregation. This drug inhibits cyclooxygenase (COX) enzyme in cyclooxygenase pathway thus preventing thrombus formation. 6 Kaempferia galanga L. and Curcuma xanthorriza Roxb. (family: Zingiberaceae) have been reported to exhibit antithrombotic activity in vitro. 7,8 Cinnamaldehyde and curcumin have been identified as the major bioactive compounds in K. galanga and C. xanthorrhiza, respectively. These compounds have been reported to be able to inhibit platelet aggregation induced by collagen, arachidonic acid, and adenosine diphosphate (ADP) which reduced the formation of thromboxane A 2 (TxA 2) in cyclooxygenase pathway. 9-10 Cinnamaldehyde had shown to inhibit collagen-and thrombin-induced aggregation of rat platelets in vitro in a Antithrombotic Effect of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. on Collagen-epinephrine Induced Thromboembolism in Mice ABSTRACT Objective: Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. have been proven to possess antiplatelet activity in vitro. The aim of this study is to investigate the antithrombotic effect of the rhizome extracts of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb in a mouse thrombotic model. Methods: The ethanol extracts of K. galanga and C. xanthorrhiza were orally administered with three different doses (7, 14 and 28 mg/20 g BW) in two experimental mouse models. Bleeding time prolongation was observed on mice tail that had been cut and the survival rate of mice was observed after thromboembolism induction by collagenepinephrine. These two experiments were observed after 7 days extracts pre-treatment and compared to the positive control, aspirin. Results: A potent effect of K. galanga and C. xanthorrhiza extracts were demonstrated through significant bleeding time prolongation compared to control group. C. xanthorrhiza extract exhibited better activity than K. galanga extract. Moreover, both K. galanga and C. xanthorrhiza extracts significantly protected mice from thromboembolic death, where the protective effect of C. xanthorrhiza extract was stronger than K. galanga extract in a dose-dependent manner. Conclusion: K. galanga and C. xanthorrhiza extracts have a potential to be developed as antithrombotic agents against platelet thromboembolism.

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“…Platelet aggregation induced by ADP was inhibited by ethanolic extract of Ramulus mori (Moraceae), a Chinese herb. This inhibition of platelet aggregation was also associated with improvement in blood circulation (Table 2) (Lee et al, 2016). Recent findings show that the raspberry and dewberry leaf extracts considerably modulated blood platelet reactivity in whole blood and potently blocked ADP-induced blood platelet aggregation (Dudzinska et al, 2016).…”

Section: Anti-adp Extracts/fractionsmentioning

confidence: 86%

Natural Sources of Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation

Fayed,

Islam,

Bangash

2021

Phytopharmacological Com.

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Platelets are central in mediating cardiovascular diseases including thrombosis. Aggregation of platelets is an important process following the adhesion of platelets to the injury site which may lead to the formation of a thrombus. Various aspects of platelet activation and aggregation could be modulated with compounds or fractions isolated from natural sources. This review summarizes these natural sources of inhibition against one of the most relevant physiological and pathological platelet agonists-adenosine diphosphate. Reported literature on the subject is further explored to discuss phytocompounds isolated from crude extracts or polarity-based fractions. Structures of the active compounds and their structure-activity relationship are also discussed.

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An ethanol extract of Ramulus mori improves blood circulation by inhibiting platelet aggregation

Cited by 9 publications

References 24 publications

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Antithrombotic Effect of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. on Collagen-epinephrine Induced Thromboembolism In Mice

Natural Sources of Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation

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