Building on historical precedents, both ancient and contemporary, the concept of Person Centered Medicine as a theoretical proposal and a practical approach has been explored since the earliest Geneva Conferences on Person Centered Medicine. At the same time, it can be said from personal and group reflection and insights that Person Centered Medicine is also an experience, an attitude, and a process.Experience is a crucial aspect of everybody’s life. Experience and trajectory is also a fundamental domain of any institution’s identity and life. This denotes the value of appraising, recognizing, and delineating institutional journeys such as that underlying the development of Person Centered Medicine.The meaning of such institutional journey may be illuminated by the consideration of Odysseus’ journey to Ithaca in Homer’s Iliad. The delineation of the itinerary and vicissitudes in the process of constructing Person Centered Medicine might contribute to the clarification and understanding of what is Person Centered Medicine as much as a philosophical analysis of its principles and arguments.