An Ethnobotanical Study of Medicinal Plants used in the Management of Dermatological Disorders in Buyende and Kayunga Districts, Uganda

Namukobe, Jane; Lutaaya, Anthony; Asiimwe, Savina; Boyer, Robert

doi:10.9734/ejmp/2021/v32i230367

Cited by 11 publications

(1 citation statement)

References 27 publications

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“…The pulp was then divided, diced, and homogenized with a mortar and pestle. To achieve a translucent liquid, muslin fabric was used as a filter (Byamukama et al, 2021).…”

Section: Aloe Barbadensis Gel Collectionmentioning

confidence: 99%

An Investigation into Development and Testing of Herbal Acne Gel Containing Vigna radiata and Aloe barbadensis

Pranshul,

et al. 2023

Intern. J. Zool. Invest.

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Long-term inflammation of the pilosebaceous unit caused by acne vulgaris can result in inflammatory lesions, seborrhea, comedones, and other conditions. It has been established that Staphylococcus epidermidis and Propionibacterium acnes are the pus-forming bacteria that cause acne inflammation. The bacteria Staphylococcus aureus contributes to acne inflammation. Natural medications are more readily accepted than their synthetic counterparts because it is generally believed that natural medicines have fewer adverse effects. On the global stage, there has been a recent uptick in inquiries for herbal preparations. The purpose of the present investigation was to develop and evaluate a herbal anti-acne gel that includes Aloe barbadensis and Vigna radiata ethanolic extract as active ingredients. Three formulations (F1, F2, F3) utilizing extracts of aloe barbadensis and vigna radiata, as well as a combination of these two extracts, were created in order to optimize the herbal anti-acne gel. A number of factors, including the formulation's physical appearance, pH, drug content, spreadability, and extrudability, were assessed. It was successfully researched how anti-acne activity assay against S. aureus works. Out of all the formulations examined, batch F3 was determined to be the most optimal for every parameter. When combined, the ethanolic extracts of Aloe barbadensis and Vigna radiata have the potential to be effective against Acne vulgaris and to work in concert with the bacteria.

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“…The pulp was then divided, diced, and homogenized with a mortar and pestle. To achieve a translucent liquid, muslin fabric was used as a filter (Byamukama et al, 2021).…”

Section: Aloe Barbadensis Gel Collectionmentioning

confidence: 99%

An Investigation into Development and Testing of Herbal Acne Gel Containing Vigna radiata and Aloe barbadensis

Pranshul,

et al. 2023

Intern. J. Zool. Invest.

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Albizia coriaria Welw ex Oliver: a review of its ethnobotany, phytochemistry and ethnopharmacology

Omara

Kiprop

Kosgei

2021

ADV TRADIT MED (ADTM)

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Albizia coriaria Welw ex. Oliver have a long history of ethnomedicinal use in the management of various diseases in Africa. Due to the frequent use of its stem bark and roots in traditional phytotherapy, the species is getting threatened in its distributional ranges. The current review was sought to document information on the ethnobotany, phytochemicals and pharmacology of different parts of A. coriaria, so as to highlight the gaps thereof for future studies. Data retrieved revealed that medicinal uses of A. coriaria have been reported for both human and veterinary ailments. Though the bark is the most commonly used, different parts of the plant are used to prepare herbal remedies for treatment of malignancies, odontological, dermatological, respiratory, gastrointestinal, reproductive, central nervous system infections/conditions and ailments. Preliminary phytochemical screening has indicated the presence of saponins, tannins, alkaloids, flavonoids, phenols, terpenes, cardiac glycosides and steroids as the major secondary metabolites in the stem bark and leaves. Like for other Albizia species, at least six triterpenoidal saponins have been characterized in organic extracts of A. coriaria stem bark and roots. Extracts and some pure compounds from A. coriaria stem bark, leaves and roots have exhibited antiproliferative (cytotoxic), antiplasmodial, molluscicidal, antigiardial, antioxidant, anti-inflammatory and antimicrobial activities. Further research should evaluate pharmacological properties such as antisnake venom, aphrodisiac, antiviral and antimycobacterial activities of the different parts of A. coriaria claimed in traditional folklore. In-depth studies on the pharmacokinetics, in vivo and clinical research utilizing extracts and isolated compounds from A. coriaria are required.

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Assessment of oral and dermal toxicity of selected ethno-medicinal plants used to treat bacterial skin infections in Uganda using Wistar albino rats

Namukobe,

Murungi,

Asiimwe

et al. 2024

Discov Toxicol

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Introduction Erlangea tomentosa S. Moore, Plectranthus caespitosus Lukhoba and Psorospermum febrifugum Spach are used in traditional medicine for management of skin and other bacterial infections in Uganda. Unlike their efficacies, the toxicity profiles have not been investigated. Therefore, this study investigated the dermal and oral toxicities of these plants in Wistar albino rats. Methods Acute and repeated oral doses of the aqueous extracts (2000 and 5000 mg/kg bw; 200 and 400 mg/kg bw respectively) and dermal doses of the organic extracts (8000 and 10,000 mg/kg bw; 2000 and 5000 mg/kg bw respectively) were administered to Wistar albino rats following OECD guidelines with slight modifications. The occluded dermal irritation and modified mouse ear swelling tests were conducted to evaluate skin irritation and sensitization potentials of the medicinal plants. Throughout the study, clinical observations were recorded, and body weights were monitored periodically. Biochemical parameters, organ weights, and histopathological analyses of the liver, kidneys, heart, stomach, and small intestines were performed to detect any signs of systemic toxicity. Additionally, phytochemical screening was carried out to identify the major classes of phytochemicals in the selected plants. Results The leaf extract of E. tomentosa showed no signs of toxicity with acute oral administration at doses of 2000 and 5000 mg/kg bw. However, repeated oral exposure at 400 mg/kg bw resulted in liver injury. Whereas no acute dermal toxicity was observed for E. tomentosa, repeated dermal exposure at 200 and 400 mg/kg bw caused necrotizing liver hepatitis. Acute oral exposure to 5000 mg/kg bw) of P. febrifugum aqueous extract increased liver weight and temporarily elevated respiration, urination, and mobility, all of which resolved within 24 h. In contrast, repeated oral exposure at 400 mg/kg bw led to reduced liver and kidney weights, with biochemical markers indicating liver injury, although histopathology revealed no significant lesions. Dermal exposure to the organic extract did not cause skin irritation or sensitization. However, repeated dermal application at 2000, 5000 and 8000 mg/kg bw led to increased bilirubin, creatinine, and AST levels, alongside decreased urea and ALP levels, suggesting cholestasis and impaired kidney function. P. caespitosus demonstrated no signs of toxicity with acute oral administration at 2000 and 5000 mg/kg bw, and repeated oral exposure at 200 and 400 mg/kg did not cause organ toxicity. No acute dermal toxicity was observed, even with repeated exposure. Conclusion & recommendation No mortality or acute toxicity was observed with oral or dermal administration of E. tomentosa, P. febrifugum, and P. caespitosus extracts in Wistar albino rats, though repeated exposure to some extracts indicated potential liver and kidney toxicity. Phytochemical analysis revealed the presence of anthraquinones, coumarins, saponins, steroids, and tannins, suggesting further investigation is needed to fully understand their toxicological profiles.

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An Ethnobotanical Study of Medicinal Plants used in the Management of Dermatological Disorders in Buyende and Kayunga Districts, Uganda

Cited by 11 publications

References 27 publications

An Investigation into Development and Testing of Herbal Acne Gel Containing Vigna radiata and Aloe barbadensis

An Investigation into Development and Testing of Herbal Acne Gel Containing Vigna radiata and Aloe barbadensis

Albizia coriaria Welw ex Oliver: a review of its ethnobotany, phytochemistry and ethnopharmacology

Assessment of oral and dermal toxicity of selected ethno-medicinal plants used to treat bacterial skin infections in Uganda using Wistar albino rats

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