An Ethnobotanical Study of Medicinal Plants in Amaro Woreda, Ethiopia

Mesfin, Fisseha; Seta, Talemos; Assefa, Abreham

doi:10.17348/era.12.0.341-354

Cited by 87 publications

(115 citation statements)

References 16 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…A preliminary phytochemical study of S. guineense leaf extract was performed using standard procedures [12, 13]. …”

Section: Methodsmentioning

confidence: 99%

“…Phytochemical compounds such as alkaloids, also found in the leaves of S. guineense , are commonly implicated for their antiplasmodial activity of many plants including Cinchona tree from which quinine, the first antimalarial drug, was isolated [10, 11]. In Ethiopia, leaf decoction of S. guineense is being used traditionally to treat malaria [12, 13]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antimalarial activity of Syzygium guineense during early and established Plasmodium infection in rodent models

Tadesse

Wubneh

2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundIn Ethiopia, the leaves of Syzygium guineense have been found useful for the prevention and cure of malaria, and demonstrated antiplasmodial activity in vitro. Nevertheless, no scientific study has been conducted to confirm its antimalarial activity in vivo. Therefore, the objective of the study was to evaluate the antimalarial effect of Syzygium guineense leaf extract in mice.MethodsInoculation of the study mice was carried out by using the malaria parasite, Plasmodium berghei. The plant extract was prepared at 200, 400 and 600 mg/kg. Chloroquine and distilled water was administered to the positive and negative control groups respectively. Parameters like parasitaemia, survival time and body weight were determined following standard tests (4-day suppressive, Rane’s and repository tests).Results Syzygium guineense crude leaf extract displayed considerable (p < 0.05) parasite suppression at doses of 600 and 400 mg/kg in a 4-day suppressive test with chemosuppressive value of 59.39 and 49.09% respectively. S. guineense crude leaf extract also showed dose-dependent schizontocidal activity in both the repository and curative tests. The extract also prevented body weight loss and prolonged survival date of mice significantly (P < 0.05) at the highest dose employed in the study. Qualitative chemical assay for S. guineense methanolic leaf extract revealed that the plant is endowed with different plant secondary metabolites exemplified by terpenoids, alkaloids, triterpenes, flavonoids, anthraquinones, tannins, glycosides, saponins and phenols.Conclusion Syzygium guineense leaf extract possess antimalarial activity in mice. The test substance was found to be safe with no observable signs of toxicity in the study mice. The results of the present work confirmed the in vitro antiplasmodial finding and traditional claims in vivo in mice. Therefore, Syzygium guineense could be regarded as a potential source to develop safe, effective and affordable antimalarial agent.

show abstract

“…A preliminary phytochemical study of S. guineense leaf extract was performed using standard procedures [12, 13]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimalarial activity of Syzygium guineense during early and established Plasmodium infection in rodent models

Tadesse

Wubneh

2017

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Ethiopia is believed to be home for about 6,500 species of higher plants, with approximately 12% of these endemic (Bekele 2007, Mesfin et al 2014, UNEP 1995. The greater concentrations of medicinal plants are found in the south and southwestern parts of the country following the concentration of biological and cultural diversity (Belayneh et al 2012, Mesfin et al 2014.…”

Section: Published: 22 June 2015mentioning

confidence: 99%

“…The greater concentrations of medicinal plants are found in the south and southwestern parts of the country following the concentration of biological and cultural diversity (Belayneh et al 2012, Mesfin et al 2014. Despite the use of traditional medicine over many centuries, relatively small numbers of tree and shrub species (TASS) have been studied for possible medical applications, and the spread of this knowledge is mostly limited to indigenous societies (Cunningham 1993).…”

Section: Published: 22 June 2015mentioning

confidence: 99%

“…Nevertheless, limited professionals have made an attempt to document medicinal TASS and traditional knowledge in some parts of Ethiopia. These include Giday (2001), Hunde (2001), Seifu (2004), Hunde et al (2006), Amenu (2007), Yineger and Yewhalaw (2007), Teklehaymanot and Giday (2007), Lulekal et al (2008), Yineger et al (2008), Mesfin et al (2009), Awas and Demissew (2009), Hailemariam et al (2009), Tamene et al (2009), Yirga (2010), Etana (2010), Hunde Feyssa et al (2011), Yirga et al (2011), Addisie et al (2012), Belayneh et al (2012), Megersa et al (2013), and Mesfin et al (2014) among others. Indeed, there is a need to do more in parts of the country where such studies have not been conducted due to the cultural diversity and the diverse flora of Ethiopia.…”

Section: Published: 22 June 2015mentioning

confidence: 99%

See 1 more Smart Citation