An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC.

Rastogi, Subha; Pandey, Madan Mohan; Rawat, Ajay Kumar Singh

doi:10.1016/j.jep.2011.04.031

Cited by 69 publications

(74 citation statements)

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“…Its roots have been used as expectorant and in snake bite and scorpion sting. It is an ingredient of Ayurvedic preparations like "Dashmoolarishta" and "Dashmoolakwaath" recommended for post-natal care to avoid secondary complications [33]. Embelia ribes Burm belongs to family Myrsinaceae also inhibit acetylcholinesterase.…”

Section: Acetylcholinesterase Inhibitors From Plantsmentioning

confidence: 99%

Acetylcholinesterase inhibition by medicinal plants: A Review

Ranjan

Kumari

2017

Ann.Pl.Sci.

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Acetylcholinesterase (AChE), the predominant cholinesterase in the brain, hydrolyzes ACh to choline and acetate, thereby terminating the effect of this neurotransmitter at cholinergic synapses. Therefore, AChE is the target of cholinesterase inhibitors used for addressing the cholinergic deficit in Alzheimer's disease (AD) patients. Despite decades of research and advances in our understanding of its aetiology and pathogenesis, current pharmacotherapeutic options for AD are still very limited and represent an area of need that is currently unmet. The leading AD therapeutics involves AChE inhibitors, resulting in increased acetylcholine concentrations in the synaptic cleft and enhanced cholinergic transmission. Compounds showing an AChE inhibitory effect are also used for the treatment of senile dementia, myastenia gravis, Parkinson's disease and ataxia. Taking into account that the inhibition of AChE has been one of the most used strategies for treating AD and that existing drugs are effective only against mild to moderate type of disease while presenting considerable side effects, the search for new sources of effective and selective anti acetylcholinesterase agents with fewer side effects is imperative. Various plants and phytochemical substances have demonstrated AChE inhibitory activity and thus could be beneficial in the treatment of neurodegenerative disorders such as AD.

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Section: Acetylcholinesterase Inhibitors From Plantsmentioning

confidence: 99%

Acetylcholinesterase inhibition by medicinal plants: A Review

Ranjan

Kumari

2017

Ann.Pl.Sci.

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“…Ils entraînent une relaxation dose dépendante liéea ub locage des canaux voltage dépendants, ce qui justifiei ndirectement l'usage de cette espèce dans les pathologies gynécologiques, en particulier les inflammations ovariennes [50]. Par ailleurs, certains auteurs [1,42] émettent l'hypothèse que l'usage de Da dans les dysménorrhées est justifié par l'effet relaxantq u'exercent les extraits de cette espèce sur des organes isolés à musculature lisse, dont le vagin de hamster.C et effet se produit par activation des canaux K+ présents à l'intérieur des cellules en présence de Ca+ et d'ATPi ntracellulaire.…”

Section: Activitésa Nti-infectieuses (Virales Bactériennese Tantiparunclassified

“…Enfin, une évaluation de la toxicité a été faite [1] en utilisant la voie intrapéritonéale d'extraits de Da : à la dose de 100 mg d'extrait sec/kg de poids, aucun effet neurologique n'a été observé,a lors qu'à 300 mg/kg, des contractions abdominales réversibles se sont produites chez 25 %d es souris. Al a dose de 10 00 mg/kg, toujours sous forme d'injection intrapéritonéale,i laé t énoté une réduction de la motricité et du comportement exploratoire, phénomènesr é versibles en 6h.…”

Section: Hegel Vol 5n°4-2 015unclassified

“…En conclusion, mis à part les résultats d'effets neurologiques [1] obtenus par une voie d'administration non conventionnelle pour tester la toxicité aiguë,l es autresr é sultats n'ont montré ni morbidité ni mortalité pour des doses allant jusqu'à 10 000 mg/Kg par voie orale chez la souris en toxicité aiguë, subaiguë et chronique. De plus, il n'a pas été mis en évidence d'éventuels effets mutagènes.…”

Section: Hegel Vol 5n°4-2 015unclassified

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Desmodium adscendens . De l’usage traditionnel camerounais contre les hépatites à l’accompagnement des chimiothérapies

Tubéry¹,

Ragot²,

Lagarde³

et al. 2015

Hegel

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RésuméDesmodium adscendens (Da) est une espèce pantropicale qui jouit d'une réputation de plante médicinale pratiquement dans tous les pays où elle croît. C'est en 1965 que le Dr P. Tubéry,a lors médecin coopérant au nord Cameroun recueillit de la bouche d'un tradipraticien des informations concernant son usage contre les hépatites et son mode de préparation. Convaincu de l'efficacité de cette espèce et de son intérêt en thérapeutique, le Dr P. Tubéry l'introduisit en France et, avec la collaboration de Mme J. Ragot, pharmacienne, mena des travaux afind emieuxc erner ses indications thérapeutiques, sa pharmacologie et sa composition chimique, ce qui conduisit à la production d'une formulation galénique reproduisant l'efficacité thérapeutique de la préparation traditionnelle. La réputation de Da s'étendit progressivement jusqu'à connaître un grand succès, et actuellement en Europe, cette espèce est devenue une référence incontournable à l'instar du Chardon Marie (Silybum marianum L. Gaertn.),e np articulier pour toutes ses applications dans les pathologies du foie (atteintes chroniques ou aiguës, en tant qu'agent curatif et/ou préventif), mais aussi pour d'autres indications. Le but cet article est de faire le point sur les travaux réaliséss ur cette espèce, dans un but de validation et de recommandations d'usage. Mots-clés

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“…Effectively, only Rastogi & Pandey [8] referred that different concentrations of a hot water extract of Desmodium adscendens showed that the extract's inhibition of histamine-induced reactions is largely competitive and that its effect of reducing histamine content is dose-dependent, and that this entire process takes 10-30 s. Besides, Mitsuma & De Hengs [9] assert that the same extract causes a dose-dependent increase of the amount of betaendorphines in the pituitary gland, competitively with the same histamine and that this complementary contingency occurs in 20min. Phytochemical investigations on hydroglyceric extract of Desmodium adscendens has led to the isolation of several alkaloids and triterpenoid saponins although there is evidence of a valuable percentage of indole-3-alkyl amines and alpha and beta phenylethylamines that play an agonistic role of paramount importance in the physiological pathway of histaminic induced reactions on safe or scarified skin [8,9].…”

Section: Introductionmentioning

confidence: 99%

Proposal of employ of extract of Desmodium adscendens as anti-histaminic natural drug: trials of efficacy by Reflectance Spectrophotometry

Martini¹,

Solimé²

2014

Our Dermatol Online

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Introduction: Aim of our study is to propose the ancient plant Desmodium adscendens, that is hitherto known for combating, when orally administered, a plethora of other ailments and diseases and considered even an anti-histaminic, for external use. An inhibition of histamine depot by inhibiting the enzymatic activity of histidine decarboxylase can be suspected, since biological principles contained in D.A. belong to the same pharmacological class of natural derivatives that elicit the same effects (nicotinic acid, cyanides and quercetine) and of synthetic alkylammines (e.g contained in bubble baths). Desmodium adscendens is a perennial plant, growing wild in Africa, especially in Camerun and Ivory Coast as well as in South and Central America and the continent of Asia. Aborigines were accustomed to employ the entire plant for rites of initiation and other shamanistic ceremonies. Notwithstanding, it has been used for thousands of years by peoples native to those areas where it grows for a variety of health issues. This plant has been studied in France, Italy, India and Canada and appreciable are the results with regard to bronchial dilation, relaxation of smooth muscles, antihistamine effects, when orally administered, albeit there is a neat evidence of an extreme paucity of references about its ability to act as a completely natural anti-histaminic herb for external use. Material and Methods: To conduct our study we have recruited 24 volunteers out from 4 categories of employees generally suffering from Type I Contact Dermatities. They were prayed to spread the hydroglyceric extract of Desmodium adscendens every morning at 10.00 a.m. and every afternoon at 03.00 p.m onto the skin of forearms and cheeks, where an artificial rash was evoked by the use of a mix made up with allergenic herbs. As far as the evaluation of the degree of severity of skin inflammation is concerned we have used the Reflectance Spectrophotoscopy, to measure the erythematous manifestation twice a day for one week: at 09.00 a.m. (to check the gravity of erythema induced in each single case) and at 04.30 p.m., to check the real efficacy of the D.A. hydroglyceric extract. We have to keep seriously on account that Reflectance Spectrophotoscopy can't evaluate histamine concentration and its characteristic effects and that the 40-50% of cases of erythematous manifestations are not rigorously ascribable to the phenomenon of the histamine release. Results and Conclussions: Results are amazingly encouraging, since it has been observed that the mean value of the blanching effect of the electuary on erythema is of 48.8%.

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An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC.

Cited by 69 publications

References 74 publications

Acetylcholinesterase inhibition by medicinal plants: A Review

Acetylcholinesterase inhibition by medicinal plants: A Review

Desmodium adscendens . De l’usage traditionnel camerounais contre les hépatites à l’accompagnement des chimiothérapies

Proposal of employ of extract of Desmodium adscendens as anti-histaminic natural drug: trials of efficacy by Reflectance Spectrophotometry

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