An Evaluation of Antibacterial Activity of Glycyrrhiza glabra Extract on the Growth of Salmonella, Shigella and ETEC E. coli

Shirazi, Mohammad Hassan; Ranjbar, Reza; Eshraghi, Seyyed Saeed; ., G. Sadeghi; Jonaidi, Nematollah; Bazzaz, N; Izadi, Morteza; Sadeghifard, Nourkhoda

doi:10.3923/jbs.2007.827.829

Cited by 22 publications

(6 citation statements)

References 12 publications

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“…Herbal antimicrobial could aid in controlling the resistant infections and aids in reducing the cost of drug regimens. 9,10 Topical gel has gained wide acceptance worldwide due to its ease of application, non-greasy and easy to remove. Although several works were conducted on using licorice gel for treatment of dermatitis or aphthous ulceration 11 , there is no marketed topical gel of licorice in the Iraqi market.…”

Section: Introductionmentioning

confidence: 99%

Formulation, evaluation and anti-microbial potential of topical Licorice root extract gel

Al-Nima¹,

Qasim²,

Alkotaji³

2020

Iraqi J. Pharm.

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Objectives: This work aims at formulating licorice as topical gel preparation and at exploring its antimicrobial efficacy against different types of microorganisms including two types of bacteria Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P.aerueginosa) and one type of yeast, Candida albicans (C.albicans).Materials and Method: Different gel formulas were prepared using two different types of gelling agent Carbopol 934 and HPMC (methocel E5) with different extract concentrations. All the prepared formulas were physically and chemically characterized, and the selected formula showed good appearance and consistency, spreadability, accepted pH and physiologically compatible to the skin. The selected formula was further characterized by studying the invitro antimicrobial activity.Result and Discussion : Results showed that licorice gel can be formulated successfully using Carbopol 934 as gelling agent and the selected formula exhibited good antimicrobial activity against (S.aureus) and (C.albicans), but it showed no antimicrobial activity against (P.aerueginosa). Consequently, the prepared topical gel of licorice could be considered as an efficient alternative to the common topical antimicrobial agents. Furthermore, the results pointed out that the prepared licorice gel has good stability at room temperature with no significant difference (p≤0.05) after storing for four months. Conclusion:In this work a suitable candidate of new herbal antimicrobial topical gel formulation was proposed to enter into the market.

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Section: Introductionmentioning

confidence: 99%

Formulation, evaluation and anti-microbial potential of topical Licorice root extract gel

Al-Nima¹,

Qasim²,

Alkotaji³

2020

Iraqi J. Pharm.

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“…The highest inhibition zone is observed on Streptococcus pyogenes ( Alwan et al, 2015 ) . The aqueous extract was less effective than ethanol extract ( Shirazi et al, 2007 ; Zhou et al, 2019 ) . Importantly, microbial resistance to antimicrobial drugs is a matter of great clinical importance; therefore, we will evaluate the antibacterial activity of licorice extract, flavonoids and triterpenoid content against resistant microorganisms such as Streptococcus, Staphylococcus aureus and Pseudomonas aeruginosa…”

Section: Prevention Of Covid-19-induced Secondary Bacterial Infectionmentioning

confidence: 85%

The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions

Gomaa

Abdel-Wadood

2021

Phytomedicine Plus

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Background Several recent studies have stated that glycyrrhizin and licorice extract are present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China. Significant data are showing that glycyrrhizin and licorice extract have multiple beneficial activities in combating most features of SARS-CoV-2 Purpose The aim of current review was to highlight recent progresses in research that showed the evidence of the potential use of glycyrrhizin and licorice extract against COVID-19. Methodology We have reviewed the information published from 1979 to October 2020. These studies demonstrated the effects , use and safety of glycyrrhizin and icorice extract against viral infections,bacterial infections, inflammatory disorders of lung ( in vitro and in vivo ). These studies were collated through online electronic databases research (Academic libraries as PubMed, Scopus, Web of Science and Egyptian Knowledge Bank). Results Pooled effect size of articles provides information about the rationale for using glycyrrhizin and licorice extract to treat COVID-19. Fifty studies demonstrate antiviral activity of glycyrrhizin and licorice extract. The most frequent mechanism of the antiviral activity is due to disrupting viral uptake into the host cells and disrupting the interaction between receptor- binding domain (RBD) of SARS-COV2 and ACE2 in recent articles. Fifty studies indicate that glycyrrhizin and licorice extract have significant antioxidant, anti-inflammatory and immunomodulatory effects. Twenty five studies provide evidence for the protective effect of glycyrrhizin and licorice extract against inflammation-induced acute lung injury and cardiovascular disorders. Conclusion The current study showed several evidence regarding the beneficial effects of glycyrrhizin and licorice extract in combating COVID-19. More randomized clinical trials are needed to obtain a precise conclusion.

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“…In the study of Shirazi et al, which investigated the antimicrobial activity of sweetness, the results showed that S. paratyphi B had the most susceptibility to the concentration of 5% of the extract, while the sweet extract had a little inhibitory effect on Shigella bacteria (21).…”

Section: Discussionmentioning

confidence: 99%

Anti-Bacterial and Anti-Biofilm Activity of Glycyrrhiza glabra, Rosmarinus officinalis and Saponaria officinalis Extracts on Important Food Pathogens

et al. 2019

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Background: Biofilms are communities of microorganisms embedded in a self-produced extracellular polymeric matrix. Bacterial cells are protected from antimicrobial agents in biofilm structure. Objectives: This article aims at exploring the anti-bacterial anti-biofilm effects of the ethanol extracts of Glycyrrhiza glabra, Rosmarinus officinalis, and Saponaria officinalis on food pathogens. Methods: Methanol extracts of Glycyrrhiza glabra, Rosmarinus officinalis, and Saponaria officinalis were prepared by rotary device. The bacterium was purchased in standard form. Finally, the antimicrobial activities of the extracts on the bacteria were measured by the microdilution method. Results: The results of this study showed that the lowest inhibitory concentration of G. garlic extract of methanol extract was 0.62 mg/mL, which was inhibited by L. monocytogenes, while B. cereus was eliminated in all concentrations of the extract. The lowest inhibitory concentration of rosemary extract was 0.62 mg/mL, which was inhibited by S. dysenterae and V. cholera, while the highest inhibitory concentration was 2.5 mg/mL, which B. cereus is restrained. The results of the study showed that the biofilm formation rate decreases with increasing concentrations of the extracts Conclusions: The result of the study showed that plant extracts have antimicrobial and anti-biofilm effects on food pathogens. Herbal extracts can be used to control food borne pathogens.

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An Evaluation of Antibacterial Activity of Glycyrrhiza glabra Extract on the Growth of Salmonella, Shigella and ETEC E. coli

Cited by 22 publications

References 12 publications

Formulation, evaluation and anti-microbial potential of topical Licorice root extract gel

Formulation, evaluation and anti-microbial potential of topical Licorice root extract gel

The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions

Anti-Bacterial and Anti-Biofilm Activity of Glycyrrhiza glabra, Rosmarinus officinalis and Saponaria officinalis Extracts on Important Food Pathogens

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