An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway

“…showed that long-term hyperglycemia-induced significant cognitive and behavioral impairments, which are concretely showed in depression, a decline of learning and memory, and the results were consistent with that of previous studies about cognitive and behavioral impairments in diabetic models 58 .…”

“…The open-field test was used to evaluate the activity and exploration desire of mice, the tail suspension test and forced swimming test was used to evaluate the depression-like behaviors, and the water maze test was used to detect spatial learning and memory ability of mice. Experimental results showed that long-term hyperglycemia-induced significant cognitive and behavioral impairments, which are concretely showed in depression, a decline of learning and memory, and the results were consistent with that of previous studies about cognitive and behavioral impairments in diabetic models [54].…”

Effect of Resveratrol, a Dietary-Derived Polyphenol, on the Oxidative Stress and Polyol Pathway in the Lens of Rats with Streptozotocin-Induced Diabetes

“…No changes in action after using both doses of resveratrol were observed. Doses of resveratrol were chosen based on the literature [ 38 , 42 , 44 , 45 , 51 , 52 , 53 , 54 ].…”

“…Since no effect on body mass, blood glucose concentration, blood fructosamine concentration, glucose and fructose concentration in the lens, which was observed after resveratrol administration, it can be presumed, that this stilbene shows no strict antidiabetic effect in this experimental model. Varsha et al, Ates et al, Schmatz et al, Yu et al, Bagatini et al, Faid et al have documented that resveratrol administered to rats with streptozotocin-induced type 1 diabetes does not cause changes in blood glucose concentrations and does not affect the body mass [ 29 , 39 , 42 , 43 , 51 , 55 ]. Other studies have demonstrated that resveratrol decreases blood glucose in animals with hyperglycaemia [ 40 , 44 , 45 , 54 ].…”

Folate Conjugated Vs PEGylated Phytosomal Casein Nanocarriers for Codelivery of Fungal- and Herbal-Derived Anticancer Drugs

“…Although RSV seems to have a negligible toxicity limit [54], the antidiabetic effect of both RSV [55] and MYPs [56] can explain the higher percentage body weight loss in free drugs combination-treated groups (16.00%) recorded at the end of the study in relative to coloaded micellar systems. Interestingly, FA-CAS MCs, F1-treated group demonstrated reduced body weight loss to 5.04%, while PEGPC-CAS MCs (F2)-treated group showed an increase rather than decrease in body weight by 2.7% confirming the efficiency of the PEGylation strategy in toxicity reduction ( Figure 5B).…”