“…Causes of failure include: incomplete obturation, root perforation, external root resorption, coexistent periodontal-periradicular lesions, grossly overfilled or overextended canals, canals left unfilled, developing apical cysts, adjacent pulpless teeth, inadvertently removed silver points, broken instruments, unfilled accessory canals, constant trauma, and nasal floor perforation (1). Recent literature has additionally suggested coronal leakage of bacteria or endotoxin as potential causes of endodontic treatment failure (3)(4)(5). The clinical significance of this leakage is debatable (6 -8).…”