An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight

Vangroenweghe, Frédéric; Goossens, L.; Jourquin, J

doi:10.1186/s40813-016-0018-1

Cited by 19 publications

(21 citation statements)

References 25 publications

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“…This is in accordance to the study by Collineau et al [45], who described the profile of ‘top-farms’ in terms of low AMU and high technical performance. Direct association of the level of external biosecurity and AMU was described in Postma et al [46], where a better external biosecurity was associated with a lower AMU in pigs from birth till slaughter. This finding was confirmed in our study where a nearly significant association between the level of external biosecurity and TI 200 days ( p = 0.06) also suggest that a lower score for external biosecurity results in more antimicrobial treatments for pigs from birth till slaughter.…”

Section: Discussionmentioning

confidence: 99%

Association between antimicrobial usage, biosecurity measures as well as farm performance in German farrow-to-finish farms

et al. 2018

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BackgroundAntimicrobial usage in food producing animals is of major concern. A clear link between the extent of use and the development of antimicrobial resistance has already been demonstrated. To evaluate strategies that may reduce the antimicrobial usage while assuring pig health and welfare, it requires profound knowledge of factors that are associated with antimicrobial usage. Data on biosecurity and herd management practices are important parameters to identify risk factors which are related to a higher antimicrobial usage. To investigate between-farm variations of high and low usage the treatment incidence (TI) per age group in 60 German farrow-to-finish herds was qualitatively and quantitatively analysed and linked to biosecurity measures, and herd management characteristics.ResultsWeaned pigs received most of the treatments (median TI = 487.6), followed by suckling pigs (median TI = 138.9). Suckling pigs were treated with critically important antimicrobials (3rd and 4th generation cephalosporines) to a remarkable extent. The number of sows present at site (p < 0.01) and a low score for external biosecurity (p = 0.06) were associated with a higher antimicrobial usage in pigs from birth till slaughter. Herds with a higher treatment incidence in growing pigs (TI 200 days): i) were located in a region with a high pig density (p < 0.01), ii) had a less strict access check for visitors and personnel (p < 0.01) and iii) scored lower in the subcategory ‘cleaning and disinfection’ (internal biosecurity) (p < 0.01). Herds with a higher treatment incidence in breeding pigs weaned more piglets per sow and year and scored better in the internal biosecurity level (p = 0.02).ConclusionsWith the main focus on the treatment incidence in pigs from birth till slaughter and in breeding pigs risk factors for a high usage in these age groups were identified. The level of biosecurity of a herd was associated with the amount of antimicrobials used. Therefore, the findings in this study indicate possible points of action in the reduction and prudent use of antimicrobials in Germany. The active improvement of biosecurity measures could be a promising alternative to reduce antimicrobial usage on herd level.Electronic supplementary materialThe online version of this article (10.1186/s40813-018-0106-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Association between antimicrobial usage, biosecurity measures as well as farm performance in German farrow-to-finish farms

et al. 2018

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“…Therefore, our findings make sense because if the treatment prevented umbilical infections, it also consequently decreased the need to treat leg problems. Zoric et al [ 32 ] showed that penicillin administration for lame suckling piglets was effective in treating leg problems. In contrast to our expectations, however, we found no difference in the need for medication to treat other diseases in the piglets.…”

Section: Discussionmentioning

confidence: 99%

The effects of amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses, growth and ampicillin resistance of intestinal coliform bacteria in weaned pigs

et al. 2017

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This study investigated the effects of a single amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses until the age of nine weeks. We also studied whether the treatment was associated with growth and mortality, the need for treatment of other diseases, the proportions of ampicillin resistant coliforms and antimicrobial resistance patterns of intestinal Escherichia coli (E. coli). A total of 7156 piglets, from approximately 480 litters, were divided into two treatment groups: ANT (N = 3661) and CON (N = 3495), where piglets were treated with or without a single intramuscular injection of 75 mg amoxicillin one day after birth, respectively. The umbilical and inguinal areas of weaned pigs were palpated at four and nine weeks of age. At the same time, altogether 124 pigs with hernias or abscesses and 820 non-defective pigs from three pens per batch were weighed individually. Mortality and the need to treat piglets for other diseases were recorded. Piglet faecal samples were collected from three areas of the floors of each pen at four weeks of age. The prevalence of umbilical hernias or abscesses did not differ between the groups at four weeks of age, but it was higher in the CON group than in the ANT group at nine weeks of age (2.3% vs. 0.7%, P < 0.05). Numbers of inguinal hernias and abscesses did not differ between the groups at four or nine weeks of age. The ANT group, when it compared with the CON group, increased the weight gain between four and nine weeks of age (LS means ± SE; 497.5 g/d ± 5.0 vs. 475.3 g/d ± 4.9, P < 0.01), and decreased piglet mortality (19.5% ± 1.0 vs. 6.9% ± 1.0, P < 0.05) and the need to treat the piglets for leg problems (3.4% ± 0.3 vs. 1.9% ± 0.3%, P < 0.01) but not for other diseases by the age of four weeks. The proportion of ampicillin resistant intestinal coliform bacteria and the resistance patterns of the E. coli isolates were not different between the ANT and CON groups. In conclusion, our results showed that the amoxicillin treatment of new-born piglets produced statistically significant effect in some of the parameters studied. However, as these effects were only minor, we did not find grounds to recommend preventive antibiotic treatment. Further, continuous antimicrobial treatment of newborn piglets could negatively influence the development of the normal microbiota of the piglet and promote selection of antimicrobial resistance genes in herds. Therefore we suggest rejection of the use of routine administration of antimicrobial agents at birth.

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“…This positive influence on embryonic survival and litter weight was suggested by Jourquin and Goossens (2011) and Vangroenweghe et al (2013) in litters from peforelin treated sows [18, 19]. The mortality rate of litters born to peforelin treated sows was significantly lower (14 versus 17%) and the birth weight was significantly higher (average of 1.24 versus 1.20 kg) than in litters from untreated control sows.…”

Section: Introductionmentioning

confidence: 61%

“…It was hypothesized that treatment with peforelin results in a more uniform pre-ovulatory pool, containing more competent and larger follicles to ovulate [20]. A more uniform pre-ovulatory follicle pool may result in a more uniform oocyte quality [37] and more uniformly developed embryos [38, 39], which could finally result in more uniform birth weights [8, 18, 19]. It has been shown that animals treated with peforelin, similar as in the present study, had larger preovulatory follicles than control and eCG treated animals [17, 20].…”

Section: Discussionmentioning

confidence: 99%

Effect of a GnRH analogue (peforelin) on the litter performance of gilts and sows

Jong

Jourquin

Kauffold³

et al. 2017

Porc Health Manag

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BackgroundMaintaining optimal reproductive and litter performance is essential for meeting economic targets in commercial pig production. Treatment with exogenous gonadotropins in sows after weaning or in gilts after altrenogest treatment has been used to stimulate follicular development leading to more piglets born and eventually higher birth weights. The effect of peforelin on litter performance was investigated in 212 gilts, primi- and pluriparous sows in three herds. Animals were randomly allocated to three treatments 24 h after weaning: peforelin (P group), eCG (E group), and physiological saline solution (C group). Numbers of total, liveborn and stillborn piglets and mortality rate during lactation were recorded. Birth weights and coefficient of variation in weights within litter were assessed. All parameters were compared among treatments.ResultsOver all parities, no difference was found among treatments in litter size nor mortality rate, but birth weights were significantly lower in the E group. Stillbirth numbers in pluriparous sows were 2.2, 0.9 and 1.4 for P, E and C groups, respectively (p = 0.04). Piglets in the P group had significantly higher live born birth weights in gilts, compared to the E group (1.36, 1.26, 1.32 kg (p < 0.02) for P, E and C group, respectively). No significant differences were found for the other investigated parameters.ConclusionsPeforelin treatment showed no improvement of litter performance compared to no treatment.

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An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight

Cited by 19 publications

References 25 publications

Association between antimicrobial usage, biosecurity measures as well as farm performance in German farrow-to-finish farms

Association between antimicrobial usage, biosecurity measures as well as farm performance in German farrow-to-finish farms

The effects of amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses, growth and ampicillin resistance of intestinal coliform bacteria in weaned pigs

Effect of a GnRH analogue (peforelin) on the litter performance of gilts and sows

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