2019
DOI: 10.21608/ajfm.2019.36574
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An Evaluation of Hepatotoxicity, Nephrotoxicity, and Genotoxicity Induced by Acute Toxicity of Hexavalent Chromium and Comparison of the Possible Protective Role of Selenium and Vitamin E on These Effects

Abstract: Introduction Hexavalent chromium Cr (VI) is a strong oxidizing toxic agent. It penetrates cell membrane and quickly reduced with production of reactive intermediates and reactive oxygen species that react with the DNA causing anomalies in the cell structure. Vitamin E (vit. E) is a lipid soluble antioxidant preventing damage to membranes also selenium (Se) is an essential micronutrient with an antioxidant activity. Aim of the present study was to evaluate the hepatotoxicity, nephrotoxicity, and genotoxicity in… Show more

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Cited by 8 publications
(7 citation statements)
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“…Our results explored that treating the groups receiving potassium dichromate with squalene and/ or vitamin E showed elevation in the level of reduced GSH as well as reduction in the elevated level of MDA when compared to the positive control group, which was in harmony to the results of a previous study (20). Meanwhile it was established by previous studies that vitamin E has the ability to safeguard against known induced ROS hepatotoxicity, genotoxicity, nephrotoxicity which estimated MDA levels as an OS marker and ascertained that it was elevated upon intoxication with potassium dichromate (21). Previous studies discovered a potent scavenging effect of squalene in comparison to vitamin E in aged population (22).…”
Section: Discussionsupporting
confidence: 87%
“…Our results explored that treating the groups receiving potassium dichromate with squalene and/ or vitamin E showed elevation in the level of reduced GSH as well as reduction in the elevated level of MDA when compared to the positive control group, which was in harmony to the results of a previous study (20). Meanwhile it was established by previous studies that vitamin E has the ability to safeguard against known induced ROS hepatotoxicity, genotoxicity, nephrotoxicity which estimated MDA levels as an OS marker and ascertained that it was elevated upon intoxication with potassium dichromate (21). Previous studies discovered a potent scavenging effect of squalene in comparison to vitamin E in aged population (22).…”
Section: Discussionsupporting
confidence: 87%
“…These negative changes can also lead to a decrease in the concentration of total protein in the blood due to its accumulation in the urine (Saidi et al, 2019). The toxic action of Cr(VI) activates the processes of free radicals formation, which in turn stimulates the processes of protein oxidation (Hassan et al, 2019). There were no statistically significant differences in blood plasma total protein level between animals intoxicated with Cr(VI) for 7 (group III) and 14 days (group IV).…”
Section: Resultsmentioning
confidence: 85%
“…The increase in the activity of ALT and AST is due to the high hepatotoxicity of K 2 Cr 2 O 7 . Cr(VI)-induced oxidative stress is accompanied by damage to hepatocyte cell membranes, after which aminotransferases enter the blood plasma (Hassan et al, 2019). Therefore, changes in blood aminotransferases activity are an important indicator of the structural and functional state of the liver (Ma et al, 2022).…”
Section: Resultsmentioning
confidence: 99%
“…The third group was allocated for AD rats receiving the heavy metal, PDC, where AD was induced just as the second group, followed by PDC (10 mg/kg body weight single i.p. injection freshly dissolved in saline 22 ) one hour after the last LPS injection. While the forth group was assigned to investigate the effect of PDC alone, as they were PDC-injected just as the third group, but one hour after the last i.p.…”
Section: Experimental Designmentioning
confidence: 99%