An Evaluation of Hormone Levels in Behçet’s Disease

Karakuş, Sema; Nar, Aslı; Toprak, Selami Koçak; Atalay, Figen; Özcebe, Osman

doi:10.5606/tjr.2012.027

Cited by 3 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Karakus et al indicated that PRL levels of male patients having ocular involvement had lower levels of inactive group, while female patients having ocular involvement had lower levels of DHEA-S compared to the active group. They found that no other remarkable hormonal difference including FSH, LH, T3, T4, TSH was observed among Behçet's patients [67]. Gül et al found that mean total testosterone levels of BD patients were significantly lower than those of healthy controls; however, patients with BD and increased 17-OH-progesteron levels only had normal total testosterone levels.…”

Section: The Role Of Stress Factors and Stress Hormones In Bdmentioning

confidence: 99%

Pathophysiology of the Behçet's Disease

Türsen

2012

Pathology Research International

View full text Add to dashboard Cite

Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Multiple systemic associations including articular, gastrointestinal, cardiopulmonary, neurologic, and vascular involvement are also observed in BD. Although the etiopathogenesis of the disease remains unknown, increased neutrophil functions such as chemotaxis, phagocytosis, and excessive production of reactive oxygen species (ROS), including superoxide anion, which may be responsible for oxidative tissue damage seen in BD, and also immunological alterations, T lymphocyte abnormalities in both subpopulation and function have been considered to be correlated with the etiopathogenesis of BD. There is some clinical evidence suggesting that emotional stress and hormonal alterations can influence the course and disease activity of BD.

show abstract

Section: The Role Of Stress Factors and Stress Hormones In Bdmentioning

confidence: 99%

Pathophysiology of the Behçet's Disease

Türsen

2012

Pathology Research International

View full text Add to dashboard Cite

show abstract

Circulating prolactin levels and Behcet's disease: A meta-analysis

Song

Lee

2018

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

This study aimed to summarize the current evidence on the relationship between circulating prolactin levels and Behcet's disease (BD). We performed a meta-analysis comparing the serum/plasma prolactin levels in patients with BD with those of controls and performed a subgroup analysis based on ethnicity, disease activity, and sex. Ten articles with a total of 320 patients with BD and 259 controls were included. The prolactin levels were not significantly higher in the BD group than in the control group (SMD=0.208, 95% CI=-0.012-0.428, p=0.064). Stratification by ethnicity indicated no elevation in prolactin level in Turkish patients with BD (SMD=0.127, 95% CI=-0.111-0.366, p=0.295). Stratification by disease activity revealed no elevation in prolactin level in both the active and inactive BD groups compared with the control group (SMD=0.373, 95% CI=-0.095-0.841, p=0.119; SMD=0.055, 95% CI=-0.243-0.354, p=0.717). Stratification by sex revealed no elevation in prolactin level in both the female and male BD groups (SMD=0.031, 95% CI=-0.398-0.460, p=0.888; SMD=0.279, 95% CI=-1.411-1.969, p=0.746). The prolactin levels were not significantly elevated in patients with BD, regardless of the adjustments for age/sex, sample size, or data type evaluated. This meta-analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls.

show abstract

Erkek Behçet Hastalarında Hormon Düzeyleri

SEZER,

ALTINYAZAR,

KOCA

et al. 2023

Abant Med J

View full text Add to dashboard Cite

Amaç: Behçet hastalığı (BH), etiyopatogenezi tam olarak bilinmeyen kronik, relapslarla seyreden sistemik inflamatuvar bir hastalıktır. Hastalığın daha çok cinsel aktif dönemde başlaması ve erkeklerde daha şiddetli klinik seyir göstermesi nedeniyle çalışmamızda erkek hastalarda hipotalamo-hipofizer-gonadal aksı değerlendirmeyi uygun gördük. Hastalar ve yöntem: Çalışmamıza 25 erkek Behçet hastası ve 22 sağlıklı erkek dahil edildi. Bu amaçla hastalarda ve sağlıklı bireylerde prolaktin, seks hormonu bağlayan globulin (SHBG), kortizol, östradiol, serbest ve total testosteron, androstenedion, dehidroepiandrosteron (DHEA), dehidroepiandrosteron sülfat (DHEAS) ve gonadotropin salgılatıcı hormon (GnRH) testine folikül stimüle eden hormon (FSH) ve luteinize hormon (LH) cevaplarına bakıldı ve sonuçlar karşılaştırıldı. Bulgular: Her iki grup arasında hormon düzeyleri incelendiğinde, hasta grubunda östradiol düzeyleri (36,80±14,70 pg/ml) kontrol grubuna (29,30±9,15 pg/ml) göre anlamlı olarak (p=0,045) daha yüksek bulundu. Hasta grubunda DHEA düzeyleri(13,74±7,96 ng/ml) kontrol grubuna (18,36±7,12 ng/ml) göre anlamlı olarak (p=0,043) daha düşük tespit edilmiştir. Diğer hormonlar açısından gruplar arasında anlamlı fark yoktu. Sonuç: BH’nin etyopatogenezi ile ilişkili olarak hormonların ve hipotalomo-hipofizer-gonadal aksın olası rolünü daha iyi değerlendirmek amacıyla özellikle hastalık aktivitesini de dikkate alan daha geniş serili çalışmalara ihtiyaç vardır.

show abstract

An Evaluation of Hormone Levels in Behçet’s Disease

Cited by 3 publications

References 10 publications

Pathophysiology of the Behçet's Disease

Pathophysiology of the Behçet's Disease

Circulating prolactin levels and Behcet's disease: A meta-analysis

Erkek Behçet Hastalarında Hormon Düzeyleri

Contact Info

Product

Resources

About