An evaluation of in vitro and in vivo free radical scavenging and antioxidant potential of ethanolic extract of Pergularia daemia

Sridevi, G.; Srividya, S.; Sembulingam, K; Sembulingam, Prema

doi:10.1016/j.bcab.2018.05.007

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…Phytochemical constituents of Pergularia daemia consists of alkaloids, flavonoids, glycoside, steroids, carbohydrates steroid, tannins and reducing sugar [70]. The pharmacological profiles includes anti-fertility activity of alkaloidal fraction, amelioratory effect of flavonoids, anti-inflammatory, analgesic and antipyretic activity, central nervous system depressant activity, hepatoprotective activity, antioxidant activity, anticancer activity, antidiabetic activity, antibacterial activity, antiurolithiatic activity, phytomedicine characteristics [69,71,72,73,74,75].…”

Section: Source: Field Survey (2017)mentioning

confidence: 99%

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Cough in Akinyele Local Government Area, Oyo State, Nigeria

Ariyo

Usman

Olorukooba

et al. 2020

EJMP

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Majority of people in developing countries rely on Traditional Medical Practitioners (TMPs) or herbalist, hunters and community elders for the treatments of various diseases and illness due to their vast knowledge of medicinal plant usage. There is need to protect the flora and fauna and also the knowledge database often stored in the memories of elders, ancestral and traditional healers. Ethnobotanical study of medicinal plants used in the treatment of cough was carried out in Akinyele Local Government with the aim to document plants and indigenous knowledge of local people in the treatment of cough. Eight villages were selected purposively due to the relics of forest in those villages. The villages are Ijaye, Onidundu, Otunagbakin, Moniya, Idi- ose, Apapa, Aroro and Olanla. Respondents were stratified into 2 strata in each of the villages, namely Traditional Medical Practitioners (TMPs) or herbalist and hunters. Within each stratum, a random selection of 10 respondents were carried out thereby making 20 respondents in each village and total number of 160 respondents as sample size. Semi structured questionnaire was used to obtain information from the respondents. The interview was conducted one-on-one using the local language (Yoruba). The data collected were analysed using descriptive statistics. The result showed that a total number of 16 plants belonging to 13 families were recorded and enumerated along with their botanical name, family and local name. Information on methods of preparation of the recipes, plant part used, form in which plant part is used, mode of administration, dosage and shelf life were also documented. There is need for domestication and conservation of these plants to prevent their extinction. The bioactive compound in some of these plants can be synthesized together to produce conventional drugs for cough. Further studies should also be carried out on these plant species to obtain more information on their bioactive properties.

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Section: Source: Field Survey (2017)mentioning

confidence: 99%

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Cough in Akinyele Local Government Area, Oyo State, Nigeria

Ariyo

Usman

Olorukooba

et al. 2020

EJMP

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“…During inflammation process, extensive disruption of protein structure through breakage of hydrogen bond, electrostatic and disulphide bonds occurs. Consequently, enzyme activators and mediators are released with cell migration and tissue breakdown which finally leads to protein conformational change and denaturation 18,19 . This protein denaturation is considered as a marker for inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2024

IJPSR

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In view of rising concern of problem associated with synthetic drugs against inflammation, current research has been focused towards safer, effective and natural compounds. Hence, we aimed at assessing the antiinflammatory effect of four plants from Solanum species (S. seaforthianum, S. diphyllum, S. sisymbriifollium and S. anguivi) through albumin denaturation assay, trypsin inhibition and RBC membrane stabilization assays. The data showed that the methanol extracts of these plants had concentration dependent protection. S. anguivi extract showed maximum inhibition of albumin denaturation (26.15 ± 0.08%), whereas S. sisymbriifollium extract displayed maximum (16.51 ± 0.002%) trypsin inhibition. With respect to heat induced RBC lysis, S. anguivi extract showed highest inhibition (26.16 ± 0.08%), whereas S. seaforthianum extract displayed maximum inhibition (36.49 ± 0.002%) of RBC lysis induced by hypotonicity. From the study, it can be inferred that anti-inflammatory activity in the tested Solanum species extract varied considerably and its activity can be attributed to its richness in phytochemical compounds.

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“…The process of protein denaturation has been characterized as a pathogenic phenomenon that entails the disruption of protein structure, leading to the subsequent loss of its functional properties (Sridevi et al 2015). A number of anti-inflammatory medicines exhibit a dose-dependent capacity to reduce thermally-induced protein denaturation (Padmanabhan and Jangle 2012).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

In vitro assessment on anti-inflammatory and anti-lipidemic properties of selected plant species

Ezung,

Kalivarathan,

Khusro

et al. 2024

BioRes

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Preliminary assessment for anti-inflammatory and anti-lipidemic properties was done with different solvent extracts derived from Urtica urens and Polygonum chinense leaves through in vitro experimentation. To evaluate anti-inflammatory properties, the stability of human red blood cells membranes and the denaturation activity of proteins were assessed. For anti-lipidemic effects, an assay was conducted to measure the inhibition of HMG-CoA reductase. The results of membrane stabilization showed IC50 values of 480.96 ± 0.02 and 319.41 ± 0.19 µg/mL for ethyl acetate extract of U. urens and P. chinense, respectively. The standard drug Diclofenac sodium exhibited IC50 value of 240.37 ± 0.04 µg/mL. For protein denaturation, IC50 values were determined as 221.75 ± 0.2 and 315.76 ± 0.19 µg/mL for U. urens and P. chinense, respectively. The IC50 value of the standard drug was calculated as 126.7 ± 0.34. The IC50 values towards HMG-CoA reductase inhibition were subsequently determined as 29.84 ± 0.35 µg/mL for U. urens and 24.34 ± 0.04 µg/mL for P. chinense against the standard drug Diclofenac sodium (7.52 ± 0.43 µg/mL). GC-MS chromatograms revealed the presence of bioactive compounds in ethyl acetate extract of P. chinense leaves. This work is substantiation for the traditional therapeutic utilization of these extracts.

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An evaluation of in vitro and in vivo free radical scavenging and antioxidant potential of ethanolic extract of Pergularia daemia

Cited by 8 publications

References 31 publications

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Cough in Akinyele Local Government Area, Oyo State, Nigeria

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Cough in Akinyele Local Government Area, Oyo State, Nigeria

Untitled

In vitro assessment on anti-inflammatory and anti-lipidemic properties of selected plant species

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