An evaluation of lower urinary tract symptoms in diabetic patients: a cross-sectional study

Qasrawi, Hala; Tabouni, Mahmoud; Almansour, Sara W; Ghannam, Mohammad; Abdalhaq, Amjad; Abushamma, Faris; Koni, Amer; Zyoud, Sa’ed H

doi:10.1186/s12894-022-01133-1

Cited by 8 publications

(9 citation statements)

References 51 publications

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“…On the other hand, the correlation between LUTS/BPH and obesity remains controversial. While many studies reinforce the idea that obesity increases the risk of BPH and LUTS ( Kim et al, 2021 ; Chen et al, 2022 ; Qasrawi et al, 2022 ; Wang et al, 2022 ), others have reported a similar pattern of voiding function in lean, overweight, and obese patients ( Bauer et al, 2022 ). In a previous report ( Calmasini et al, 2017 ), we showed that obesity caused prostate hyperplasia, insulin resistance, and greater contractile responses to a 1 -adrenoceptor agonists.…”

Section: Discussionmentioning

confidence: 90%

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

et al. 2023

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Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. In this study, we examined the effect of periprostatic adipose tissue supernatant obtained from obese mice on prostate reactivity in vitro and on the viability of human prostatic epithelial cell lines.Methods: Male C57BL/6 mice were fed a standard or high-fat diet after which PPAT was isolated, incubated in Krebs-Henseleit solution for 30 min (without prostate) or 60 min (with prostate), and the supernatant was then collected and screened for biological activity. Total nitrate and nitrite (NOx−) and adenosine were quantified, and the supernatant was then collected and screened for biological activity. NOx− and adenosine were quantified. Concentration-response curves to phenylephrine (PE) were obtained in prostatic tissue from lean and obese mice incubated with or without periprostatic adipose tissue. In some experiments, periprostatic adipose tissue was co-incubated with inhibitors of the nitric oxide (NO)-cyclic guanosine monophosphate pathway (L-NAME, 1400W, ODQ), adenylate cyclase (SQ22536) or with adenosine A2A (ZM241385), and A2B (MRS1754) receptor antagonists. PNT1-A (normal) and BPH-1 (hyperplasic) human epithelial cells were cultured and incubated with supernatant from periprostatic adipose tissue for 24, 48, or 72 h in the absence or presence of these inhibitors/antagonists, after which cell viability and proliferation were assessed.Results: The levels of NOx− and adenosine were significantly higher in the periprostatic adipose tissue supernatant (30 min, without prostate) when compared to the vehicle. A trend toward an increase in the levels of NOX was observed after 60 min. PPAT supernatant from obese mice significantly reduced the PE-induced contractions only in prostate from obese mice. The co-incubation of periprostatic adipose tissue with L-NAME, 1400W, ODQ, or ZM241385 attenuated the anticontractile activity of the periprostatic adipose tissue supernatant. Incubation with the supernatant of periprostatic adipose tissue from obese mice significantly increased the viability of PNT1-A cells and attenuated expression of the apoptosis marker protein caspase-3 when compared to cells incubated with periprostatic adipose tissue from lean mice. Hyperplastic cells (BPH-1) incubated with periprostatic adipose tissue from obese mice showed greater proliferation after 24 h, 48 h, and 72 h compared to cells incubated with culture medium alone. BPH-1 cell proliferation in the presence of PPAT supernatant was attenuated by NO-signaling pathway inhibitors and by adenosine receptor antagonists after 72 h.Conclusion: NO and adenosine are involved in the anticontractile and pro-proliferative activities of periprostatic adipose tissue supernatant from obese mice. More studies are needed to determine whether the blockade of NO and/or adenosine derived from periprostatic adipose tissue can improve prostate function.

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Section: Discussionmentioning

confidence: 90%

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

et al. 2023

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“…Factors such as not engaging in exercise, HTN, and DM were associated with higher IIQ-7 scores, indicating a greater impact of UI on daily activities. Managing these modifiable risk factors may positively influence the overall impact of UI on daily life [ 18 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our group has published several papers about lower urinary tract symptoms (LUTS) and UI among different cohorts of patients in Palestine [18][19][20][21][22]. This was a national study investigating the prevalence of UI and the factors that influence it.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Risk Factors, and Impact on Quality of Life Due to Urinary Incontinence Among Palestinian Women: A Cross-Sectional Study

Abushamma,

Mansour,

Nassar

et al. 2024

Cureus

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Introduction: Urinary incontinence (UI) is a common condition that affects females with variable incidence. Factors like age, obesity, weak pelvic floor, and pregnancy contribute to UI pathogenesis. Our study aimed to determine the prevalence of UI and identify associated risk factors. Methods: A cross-sectional study recruited females aged 18-65 attending primary health care (PHC) centers. The collected data included demographic information and questionnaire scores for urinary incontinence diagnosis (QUID), International Consultation on Incontinence Questionnaire-Urinary Incontinence (ICIQ-UI), and Incontinence Impact Questionnaire-Short Form (IIQ-7) scores. Results: Three hundred and eleven females met our inclusion criteria, with 162 (52.1%) participants aged ≥ 42 years. Approximately 41.5% were college/university graduates, and 23.2% had an education level less than high school. Moreover, 108 (34.7%) participants were smokers, 223 (71.7%) drank coffee, and approximately 212 (68.2%) drank tea. Only 125 (40.2%) participants engaged in exercise at variable frequencies, and most of them exercised once per week. Approximately 27.3% of the participants had chronic medical illness with hypertension or diabetes mellitus (40 (12.9%) or 25 (8%), respectively). Stress urinary incontinence (SUI) was found among 152 (48.9%) participants, while urgency urinary incontinence (UUI) was found among 114 (36.7%) participants. Age ≥ 42, marital status, low educational level, unemployment, lack of physical activity, and chronic medical illnesses were significantly correlated with both SUI and UUI. There was a strong correlation between UI and the severity of symptoms and between UI and quality of life (QoL). Conclusion: The prevalence of UI is relatively high among Palestinian women. Many factors contributing to UI included age, marital status, the presence of other chronic medical diseases, and a lack of physical activity. Early detection and diagnosis are necessary to provide effective treatment and improve UI symptoms and QoL.

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“…A score that is equal to or greater than 8 indicates the presence of clinically significant LUTS. The IPSS values were classified as mild (scores 0-7), moderate (scores [8][9][10][11][12][13][14][15][16][17][18][19], and severe (scores 20-35) LUTS. Furthermore, the IPSS incorporates an 8th question, a quality-of-life assessment, in the form of a single 7-point scale question, inquiring about the patient's hypothetical feelings if they were to live with their current urinary condition for the rest of their life.…”

Section: The International Prostate Symptom Score (Ipss)mentioning

confidence: 99%

“…Differences were found in the gender distribution and prevalence of the cardiovascular disease across classes, with patients experiencing “severe multiple symptoms” and “urinary incontinence” reporting the lowest HRQOL. It is also crucial to highlight that LUTS can have a hidden neurological cause in patients without a formally diagnosed neurological disorder (“occult neurology”) [ 9 ] or hide another underlying medical condition like cardiovascular disease or diabetes type 2 [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Lower Urinary Tract Symptoms in Males and Urinary Incontinence in Females in Primary Health Care in Greece

Gkatzoudi,

Bouloukaki,

Mamoulakis

et al. 2024

Medicina

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Background and Objectives: The significant prevalence of Lower Urinary Tract Symptoms (LUTS), erectile dysfunction (ED), and associated adverse effects calls for increased attention in primary care settings. In Greece, there is a lack of sufficient data for LUTS and ED screening in primary care. Therefore, the aim of our study was to estimate the prevalence of LUTS and ED, identify associated risk factors, and evaluate their impact on quality of life among adult primary healthcare users aged 40 years and older in Crete, Greece. Materials and Methods: A cross-sectional study was conducted to explore the prevalence of LUTS and ED in 1746 primary health care users visiting rural primary health care practices in Crete, Greece. Participants underwent a comprehensive evaluation including demographic parameters, screening for LUTS utilizing the validated International Prostate Symptoms Score (IPSS) questionnaire and for ED using the International Index of Erectile Function (IIEF-5), in males, and for urinary incontinence in women with the International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form (ICIQ-UI SF). Participants with a prior diagnosis of LUTS or ED were excluded (n = 183). Results: Out of 536 participants finally included (n = 1746 screened), 32% of males and 36% of females exhibited moderate to severe LUTS. Following adjustments, we identified advanced age, retirement, and the presence of diabetes type 2 as factors associated with the occurrence of LUTS in men. Patients with LUTS also had a substantially increased likelihood of experiencing ED. Moreover, it was observed that women with hypertension or diabetes type 2 and lower education levels face an increased likelihood of developing LUTS, which adversely affects their quality of life. Conclusions: In conclusion, the findings of this study reveal a high occurrence of LUTS and ED in adults aged 40 years and older who utilize primary healthcare services, with a negative impact on their quality of life.

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An evaluation of lower urinary tract symptoms in diabetic patients: a cross-sectional study

Cited by 8 publications

References 51 publications

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

Prevalence, Risk Factors, and Impact on Quality of Life Due to Urinary Incontinence Among Palestinian Women: A Cross-Sectional Study

Evaluation of Lower Urinary Tract Symptoms in Males and Urinary Incontinence in Females in Primary Health Care in Greece

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