An Evaluation of Mafenide Acetate in Experimental Burn Wound Sepsis

Dressler, Donald P.; Rozin, R; Skornik, William A.; Bellas, A. E.; Soroff, Harry S.

doi:10.1001/archsurg.1967.01330180148024

Arch Surg

1967

DOI: 10.1001/archsurg.1967.01330180148024

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An Evaluation of Mafenide Acetate in Experimental Burn Wound Sepsis

Donald P. Dressler¹,

R Rozin²,

William A. Skornik³

et al.

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Cited by 16 publications

(1 citation statement)

References 5 publications

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“…[4][5][6][7][8] Silver is a board-spectrum antimicrobial agent that is active against yeast, mold, and bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancoymcin-resistant Enterococcus (VRE), whenever provided at appropriate concentration. [4][5][6][7][8] Silver is a board-spectrum antimicrobial agent that is active against yeast, mold, and bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancoymcin-resistant Enterococcus (VRE), whenever provided at appropriate concentration.…”

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confidence: 99%

A Pilot Study of the Use of Biocide-Impregnated Gauze as an Adjunct to Wound Care in a Burn Population

Wibbenmeyer

Williams

Liao

et al. 2012

Journal of Burn Care & Research

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The aim of this study was to evaluate the use of a polyhexamethylene biguanide biocide-impregnated gauze (Kerlix™ AMD gauze dressing, Covidien d/b/a Tyco Healthcare Group LP) as an adjuvant to routine burn care and its impact on the incidence of hospital-associated infections in burn population. One hundred eight burn patients admitted to the Burn Treatment Center were prospectively enrolled from August 2008 to June 2009 and matched 1:2 with historic controls who were admitted from March 2006 to July 2008. Clinical care remained otherwise unchanged; however, several hospital initiatives (the national surgical improvement project, the surgical care improvement project, and a central venous line bundle) were initiated before and during the study. There were significantly less infections in the study population (18.52% of case patients vs 28.70% of control patients had infections, P = .047). Although there was a decrease in each infection subtype analyzed, a statistically significant reduction was only reached for pneumonias (1.85% in cases vs 5.86 in controls, P = .042). Implementation of polyhexamethylene biguanide biocide-impregnated gauze was temporally correlated with a significant decrease in healthcare-associated infections in burn population. As there was no corresponding decrease in wound infections, the impact of the gauze on healthcare-associated infections, if any, cannot be conclusively determined by this study. A larger prospective study powered to detect a decrease in wound-related infections is warranted.

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confidence: 99%

A Pilot Study of the Use of Biocide-Impregnated Gauze as an Adjunct to Wound Care in a Burn Population

Wibbenmeyer

Williams

Liao

et al. 2012

Journal of Burn Care & Research

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Topical Application of Mafenide Acetate

Yaffee¹

1969

Arch Dermatol

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Contact Dermatitis to Mafenide Acetate

Velasco¹

1971

Arch Dermatol

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An Evaluation of Mafenide Acetate in Experimental Burn Wound Sepsis

Cited by 16 publications

References 5 publications

A Pilot Study of the Use of Biocide-Impregnated Gauze as an Adjunct to Wound Care in a Burn Population

A Pilot Study of the Use of Biocide-Impregnated Gauze as an Adjunct to Wound Care in a Burn Population

Topical Application of Mafenide Acetate

Contact Dermatitis to Mafenide Acetate

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