Pain and wound after haemorrhoidectomy constantly bothered the patient's convenience. Recurrently, topical sucralfate is used to treat excoriations and burns. It is considered to enhance epidermal growth and tissue granulation, thus, alleviating patients' problems. This study evaluated topical sucralfate's feasibility, safety, and superiority after haemorrhoidectomy. We searched randomised controlled trial (RCT) studies in PubMed, Google Scholar, Europe PMC, and ClinicalTrials.gov until March 29th, 2022. We investigated the influence of topical sucralfate on pain score postoperatively (24 hours, 7 days, and 14 days), pethidine usage, diclofenac usage, and wound healing rate compared to placebo. This study was conducted following the PRISMA guidelines. This study sorted the final six studies with 439 patients underwent haemorrhoidectomy. Topical sucralfate demonstrated significant outcomes on VAS 24 hours post-operative [Std. Mean Difference À1.00 (95% CI À1.70, À0.31), P = .005], VAS 7 days post-operative [Std. Mean Difference À2.29 (95% CI À3.34, À1.25), P < .0001], VAS 14 days post-operative [Std. Mean Difference À1.88 (95% CI À2.74, À1.01), P < .0001], pethidine usage within 24 hours post-operative [Std. Mean Difference À0.62 (95% CI À0.96, À0.27), P = .0004], diclofenac usage 7 days post-operative [Std. Mean Difference À1.76 (95% CI À2.61, À0.92), P < .0001], diclofenac usage 14 days post-operative [Std. Mean Difference À1.64 (95% CI À2.38, À0.91), P < .0001], and wound healing rate at 28-day post-operative [RR 1.45 (95% CI 1.25-1.68), P < .00001]. Topical sucralfate alleviated pain, improved wound healing, and minimised the usage of pethidine and diclofenac compared to placebo.