An Evaluation of Naloxone as a Gastric Cytoprotective Agent during Hemorrhagic Shock

Moran, Donald M.; Larsen, Kenneth R.; Russo, John; Davis, E.K.; Moody, Frank G.

doi:10.1097/00005373-198408000-00006

The Journal of Trauma: Injury, Infection, and Critical Care

1984

DOI: 10.1097/00005373-198408000-00006

|View full text |Cite

An Evaluation of Naloxone as a Gastric Cytoprotective Agent during Hemorrhagic Shock

Donald M. Moran

Kenneth R. Larsen

John Russo

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1992

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Naloxone and Restraint Stress: Effects on Gastric Mucosal Injury and Gastric Function

Kleiman‐Wexler,

Ephgrave,

Adair

1992

Pharmacotherapy

View full text Add to dashboard Cite

Contradictory findings have been reported from previous investigations of the effects of opiate receptor blockade on stress‐related gastric injury. We performed two studies of the effects of naloxone on gastric mucosal injury and gastric function in cold restraint stress. In the first, naloxone had a linear, dose‐dependent effect, reducing mucosal injury both parenterally and enterally. Gastric acidity was not related to the dose of naloxone, or to the amount or extent of mucosal injury. Gastric residual volume, by contrast, was related to both naloxone dose and gastric mucosal injury. In the second study we investigated the effect of gastric distention by enteral vehicle in the restraint model, and the interaction of the vehicle with the effects of naloxone. Periodic distention of the stomach with enteral vehicle did not alter the drug's effects on mucosal injury or on gastric residual volume. Because cold restraint stress produces harmful gastric contractions, naloxone is likely to be protective by altering gastric motility.

show abstract

Naloxone and Restraint Stress: Effects on Gastric Mucosal Injury and Gastric Function

Kleiman‐Wexler,

Ephgrave,

Adair

1992

Pharmacotherapy

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

An Evaluation of Naloxone as a Gastric Cytoprotective Agent during Hemorrhagic Shock

Cited by 1 publication

References 0 publications

Naloxone and Restraint Stress: Effects on Gastric Mucosal Injury and Gastric Function

Naloxone and Restraint Stress: Effects on Gastric Mucosal Injury and Gastric Function

Contact Info

Product

Resources

About