An Evaluation of Nucleated Red Blood Cell Count by an Automated Haematology Analyser- A Tertiary Centre Experience

Khanna, Ruchee; Nayak, Manjushree; Verma, Seemitr; Lavanya, P; Shetty, Tanvi; Kumari, Shantha; Zeeshan, S M

doi:10.14260/jemds/2020/412

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…The level of red blood cells and hematocrit at different days, i.e., days 14, 18, and 21 was also significant ( p ≤ .05). In case of cigarette‐smoke‐induced lung injury, the amount of carboxyhemoglobin increased which then leads to the state of hypoxia which causes excessive secretion of erythropoietin to initiate the production of RBCs (Khan et al, 2014) which further leads to an increase in hemoglobin level (Leifert, 2008). The carbon monoxide present in cigarette smoke elevates the permeability of capillaries which then results in a decrease in plasma volume.…”

Section: Resultsmentioning

confidence: 99%

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Analyzing cross‐talk of EPO and EGF genes along with evaluating therapeutic potential of Cinnamomum verum in cigarette‐smoke‐induced lung pathophysiology in rat model

Anwar

Navaid

Muzaffar

et al. 2023

Food Science & Nutrition

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The integrity of the distal alveolar epithelium is crucial for lung regeneration following an injury. The present study aimed to evaluate the effect of Cinnamomum verum extract; cross-talk of epidermal growth factor (EGF) and erythropoietin (EPO) genes in a smoke-induced lung injury rat model. For experimentation (n = 27), albino rats were divided equally into three groups, i.e., negative control (NC), positive control (PC), and treatment group (TG). Cigarette smoke was exposed to PC and TG (4 CG/ day). C. verum was given orally (350 mg/kg body weight) for 21 days. Decapitation (n = 3) was done on 14th, 18th, and 21st days, respectively. Analyses (hematology, biochemical, high performance liquid chromatography [HPLC], histology, and gene expression) were carried out and results were statistically analyzed by two-way analysis of variance. HPLC analysis of ethanolic extract of C. verum was done to identify the presence of phenolic constituents which showed high concentrations of quercetin and P-coumaric acid. Serum oxidative parameters such as total oxidant status, malondialdehyde, and hematological parameters such as red blood cells, hemoglobin, hematocrit, and white blood cells were significantly (p < .05) elevated in the PC group; however, these parameters were significantly (p < .05) improved in TG. While total antioxidant capacity and serum parameters such as total protein, albumin, and globulin were significantly (p < .05) reduced in the PC group but significantly improved (p < .05) in TG. Histological analysis revealed that smoke exposure resulted in a measurable increase in alveolar septal thickening while ethanolic extract of C. verum greatly ameliorated the histopathological changes in the lung alveoli. The gene expression analysis of EGF and EPO genes showed a significant upregulation (p < .05) of both genes in PC group while in TG, the level of both genes downregulated, in which lung damage was ameliorated due to cytoprotective effects of ethanolic extract of C. verum.

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Section: Resultsmentioning

confidence: 99%

“…This state mimics the state of polycythemia which is characterized by an increase in the share of RBCs in the blood volume. Thus, the hematocrit level increased due to cigarette-smoke-induced lung injury (Khan et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Analyzing cross‐talk of EPO and EGF genes along with evaluating therapeutic potential of Cinnamomum verum in cigarette‐smoke‐induced lung pathophysiology in rat model

Anwar

Navaid

Muzaffar

et al. 2023

Food Science & Nutrition

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“…Pada orang sehat merokok menyebabkan peningkatan kadar Hb yang kemungkinan dimediasi oleh paparan karbon monoksida (CO) yang berikatan dengan Hb membentuk karboksihemoglobin (HbCO). Rata-rata kadar Hb dan kadar HbCO meningkat secara progresif dengan jumlah rokok yang dikonsumsi per hari (Khan et al, 2014).…”

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Risk Factors for Abnormal Hemoglobin Levels in Online Motorcycle Taxi Drivers in the Tanjung Mas Industrial Area, Semarang City

Setyowatiningsih,

Wikandari

2023

JLM

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Air pollution can affect health conditions, CO and Pb are one of the compositions of vehicle exhaust gases that are dangerous. Online motorcycle taxi drivers have a high risk of exposure to pollutants. This research aims to determine the risk factors that affect hemoglobin levels in online motorcycle taxi drivers in the Tanjung Emas Area of Semarang City. The method used observational analytics with a cross-sectional approach. The total population in this study was 55 respondents and the number of respondents was determined using total sampling. Based on the results of examining hemoglobin levels using a hematology analyzer, of 55 respondents, 47 respondents had normal hemoglobin levels and 8 respondents had abnormal hemoglobin levels. The results of the Chi square test on smoking status have a significant relationship (p=0.04) to the blood hemoglobin level of online motorcycle taxis in the Tanjung Emas Area of Semarang city while in the status of Education, length of work, and knowledge there is no significant relationship (0.05) to the hemoglobin level of online motorcycle taxi drivers in the Tanjung Emas Area of Semarang City. The conclusion of this study is that there is a significant relationship between smoking status and hemoglobin levels of online motorcycle taxi drivers in the Tanjung Emas Area of Semarang City and there is no significant relationship between education factors, length of work time, and knowledge of hemoglobin levels of online motorcycle taxis in the Tanjung Emas Area of Semarang City.

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An Evaluation of Nucleated Red Blood Cell Count by an Automated Haematology Analyser- A Tertiary Centre Experience

Cited by 2 publications

References 8 publications

Analyzing cross‐talk of EPO and EGF genes along with evaluating therapeutic potential of Cinnamomum verum in cigarette‐smoke‐induced lung pathophysiology in rat model

Analyzing cross‐talk of EPO and EGF genes along with evaluating therapeutic potential of Cinnamomum verum in cigarette‐smoke‐induced lung pathophysiology in rat model

Risk Factors for Abnormal Hemoglobin Levels in Online Motorcycle Taxi Drivers in the Tanjung Mas Industrial Area, Semarang City

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