An Evaluation of Preoperative Bowel Preparation in Elective Colorectal Surgery

Ono, Shunsuke; S, Kodaira; Takizawa, Ken; Kotake, Kenjiro; Satoshi,; Ikoma, M.; Katsumata, Takao; Takada, Yuki; Miyata, Junichi; Ishibiki, Kuya; Abe, Osahiko

doi:10.5833/jjgs.14.86

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…It was observed that during study, the animals of this group had suffered from fever for three to four days that's why the gain in the tensile strength was lower than the groups having single dose of intravenous antibiotic prophylaxis. These findings are also inline with those of Athar et al, Cai (1992) , Leaper (1994), Lindhagen et al, (1981), Mittermayer et al, (1984) Ono et al, (1990) Parker et al, (1985 Playforth et al, (1988) and Takesue et al, (2000). As for the choice of antimicrobial agents, it is general consensus worldwide that administration of prophylactic antibiotics should be intravenous as single dose preferably 1 hour to 30 minutes before surgery.…”

Section: Discussionsupporting

confidence: 76%

Comparative Prophylactic Administration Effect of Metronidazole, Ceftriaxone Sodium and their Combination on the Tensile Strength of End-to-End Jejunal Anastmotic Site in Dogs

Rafique¹,

Asi²,

Saqib³

et al. 2013

IJVMR

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Intestinal resections are most commonly performed in dogs and currently it is involved with extensive use of different antibiotics before surgical intervention. Metronidazole and cephalosporins are considered as best choice for prophylactic use in gastrointestinal operations. Therefore, the study is established to reveal the comparative effect of metronidazole, ceftriaxoine sodium and their combination on the tensile strength of jejunual anastomotic site. A total of twenty healthy stray dogs were included in this study. These dogs were randomly divided into four groups, which underwent end to end jejunal ansastmosis. The dogs in Group I (control) were operated for jejunal anstomosis without any antibiotic prophylaxis. The metronidazole alone was administered intravenously to dogs in Group II at the dose rate of 50mg/kg while the dogs in Group III were administered with intravenous ceftriaxone sodium at the dose rate of 30mg/Kg body weight two hours prior to surgery. The dogs in Group IV were given metronidazole in combination with ceftriaxone sodium by intravenous route at the dose rate of 50mg/Kg and 30mg/kg respectively two hours before surgical intervention. A significant difference was noted in the tensile strength between the four studied groups (P < 0.05). The study concluded that the combination of ceftriaxone sodium with metronidazole was found to enhance the gain in tensile strength significantly i.e. 47.50 %.

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