An evaluation of quantitative agarose-gel electrophoresis of serum lipoproteins

Intravenous aminophylline 0.48 g produced a sharp increase in plasma free fatty acids. After three days of treatment with aminophylline 0.96 g/day i.v., plasma post-heparin lipoprotein lipase was significantly reduced, and post-heparin hepatic triglyceridase remained unchanged. alpha 1 lipoprotein was reduced by treatment, in parallel with lipoprotein lipase, while other lipoprotein fractions, serum cholesterol and triglycerides were unaffected.

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Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha1lipoprotein level after aminophylline in man

Zanaboni

Bonfiglioli

Sommariva

et al. 1981

Eur J Clin Pharmacol

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Influence of two non-steroidal anti-inflammatory drugs on lipolysis and on plasma post-heparin lipoprotein lipase activity in normal man

Bonfiglioli

Sommariva

Zanaboni

et al. 1981

Eur J Clin Pharmacol

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Indomethacin 50 mg i.v. or p.o. and diclofenac sodium 50 mg p.o. produced a prompt and significant increase in plasma free fatty acid concentration. In 10 subjects who took indomethacin 150 mg/d p.o. for 3 days, plasma post-heparin lipoprotein lipase activity was also significantly increased. The same effect occurred in 9 subjects treated for 3 days with diclofenac sodium 50 mg t.d.s. Since both indomethacin and diclofenac sodium are potent inhibitors of prostaglandin synthetase, these findings are consistent with the hypothesis tht prostaglandins are involved in the feed-back regulation of lipolysis, and mediate the inhibitory effect of lipolysis on lipoprotein lipase activity.

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Serum lipoproteins in diabetes: Relation of alpha-lipoprotein level to therapy

et al. 1980

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Three hundred and sixty diabetic patients (125 on insulin, 109 on sulfonylureas and 126 on diet alone) were selected to investigate the effect of the type of treatment and of the degree of metabolic control on serum lipoproteins. Prebeta-lipoprotein concentration was higher than normal in all treatment groups. Beta-lipoproteins were significantly higher in diabetic women than in controls. No difference in beta- and prebeta-lipoprotein concentration existed between the 3 treatment groups. Alpha-lipoproteins were significantly higher in insulin-treated than in diet-treated patients irrespective of the degree of metabolic control. The daily dose of insulin and, in patients on diet or sulfonylureas, serum IRI were positively correlated to alpha-lipoprotein concentration while this lipoprotein fraction was not significantly correlated to fasting blood sugar. Alpha-lipoprotein concentration, then, appears to be markedly influenced by exogenous and endogenous insulin, independently of the degree of metabolic control.

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An evaluation of quantitative agarose-gel electrophoresis of serum lipoproteins

Cited by 3 publications

References 11 publications

Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha1lipoprotein level after aminophylline in man

Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha1lipoprotein level after aminophylline in man

Influence of two non-steroidal anti-inflammatory drugs on lipolysis and on plasma post-heparin lipoprotein lipase activity in normal man

Serum lipoproteins in diabetes: Relation of alpha-lipoprotein level to therapy

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