An evaluation of salivary scintigraphy in sögren's syndrome

Daniels, T.; Powell, Malcolm R.; Sylvester, Robert A.; Talal, Norman

doi:10.1002/art.1780220801

Cited by 73 publications

(23 citation statements)

References 5 publications

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“…Salivary scanning with the same radionuclide is more sensitive than sialography in SS (18), but scintigraphy is more effective than either because it examines the 4 major salivary glands simultaneously. Although these changes correlate with LSG biopsy focus scores (10) and parotid flow rate measurements (10,19), their disease specificity is inadequately established for use as a diagnostic criterion in SS.…”

Section: Discussionmentioning

confidence: 99%

Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

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501

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Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of >1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease‐specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.

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Section: Discussionmentioning

confidence: 99%

Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

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501

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“…Scintigraphic changes correlate well with salivary scintigraphic abnormalities [9, 10]and histopathological changes [11, 12]. With salivary scintigraphy, the major salivary glands can be examined simply, noninvasively, simultaneously, and continuously.…”

Section: Introductionmentioning

confidence: 99%

Evidence for Decreased Salivary Function in Patients with Reflux Esophagitis

Kao

Ho²,

ChangLai³

et al. 1999

Digestion

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It has been speculated that impaired salivary flow contributes to abnormal acid clearance of the esophagus in gastroesophageal reflux and results in reflux esophagitis (RE). To test this hypothesis, salivary functions were measured by quantitative salivary scintigraphies in patients with RE and in age- and sex-matched controls for comparison. Nineteen patients with RE and 36 healthy volunteers were enrolled in the study. After an intravenous injection of 5 mCi Tc-99m pertechnetate, sequential images of 1 min/frame were acquired for 30 min. The 1- and 15-min uptake ratios (UR) of the tracer in the four major salivary glands over the backgrounds were calculated. Saliva excretion was stimulated by 1 tablet of 200 mg ascorbic acid given orally 15 min after injection of the tracer, then the maximal excretion ratios (ER) of the four major salivary glands were calculated for the sialagogue stimulation. RE patients had lower values of 1st and 15th min UR and maximal ER than controls in the 4 major salivary glands. Poor salivary functions which represented a decrease in both UR and ER for patients with RE have been confirmed by quantitative salivary scintigraphy in this study.

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“…A number of other approaches, such as sialography and salivary gland scans, have been used (7,8), and the results appear to correlate with those found using other criteria for SS (27,28). However, data on the use of these other techniques are inadequate to support their use as diagnostic criteria for SS (lo), and such tests are relatively expensive.…”

Section: Clinical Evaluation Of the Patient With Sicca Complaintsmentioning

confidence: 90%

Untitled

1986

Arthritis & Rheumatism

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An evaluation of salivary scintigraphy in sögren's syndrome

Cited by 73 publications

References 5 publications

Labial salivary gland biopsy in sjögren's syndrome

Labial salivary gland biopsy in sjögren's syndrome

Evidence for Decreased Salivary Function in Patients with Reflux Esophagitis

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