An evaluation of scrapie surveillance in the United States

Lynn, Tracey V.; Grannis, J. L.; Williams, Michael S.; Marshall, Katherine L.; Miller, Ryan S.; Bush, Eric J.; Bruntz, S.

doi:10.1016/j.prevetmed.2007.04.001

Cited by 17 publications

(17 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with genetic relationships to a wide variety of TSEs, including kuru and sporadic Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and chronic wasting disease in elk and deer [3,[12][13][14]18,19]. Scrapie eradication programs worldwide involve breeding sheep based upon the most resistant alleles, and scrapie prevalence has been falling using such measures [16].…”

Section: Introductionsupporting

confidence: 69%

Prion gene (PRNP) haplotype variation in United States goat breeds(Open Access publication)

et al. 2008

View full text Add to dashboard Cite

-Scrapie eradication efforts cost 18 million dollars annually in the United States and rely heavily upon PRNP genotyping of sheep. Genetic resistance might reduce goat scrapie and limit the risk of goats serving as a scrapie reservoir, so PRNP coding sequences were examined from 446 goats of 10 breeds, 8 of which had not been previously examined at PRNP. The 10 observed alleles were all related to one of two central haplotypes by a single amino acid substitution. At least five of these alleles (M142, R143, S146, H154, and K222) have been associated with increased incubation time or decreased odds of scrapie. To the best of our knowledge, neither S146 nor K222 has been found in any goats with scrapie, though further evaluation will be required to demonstrate true resistance. S146 was more common, present in several breeds at widely varying frequencies, while K222 was observed only in two dairy breeds at low frequency. Overall, this study provides frequency data on PRNP alleles in US goats, shows the pattern of relationships between haplotypes, and demonstrates segregation of multiple scrapieassociated alleles in several breeds not examined before at PRNP. scrapie / goat / polymorphism / resistance / prion

show abstract

Section: Introductionsupporting

confidence: 69%

Prion gene (PRNP) haplotype variation in United States goat breeds(Open Access publication)

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Extended incubation time can create difficulties in correctly diagnosing exposed animals. Furthermore, retrospective tracing of chains of exposure in scrapie eradication programs (Lynn et al, 2007) may become more difficult with longer incubation times such as those conferred by S146 or K222 because of the longer relevant exposure histories.…”

Section: Discussionmentioning

confidence: 99%

“…In sheep, strong resistance to classical scrapie is conferred by the R171 substitution in PRNP which occurs on the "ARR" haplotype representing codons 136, 154, and 171 (Westaway et al, 1994). This resistance is a key component of scrapie eradication programs in many parts of the world, along with trace-backs of infected animals to eliminate as many infectious sources as possible (Lynn et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222

White

Reynolds

Waldron³

et al. 2012

Gene

View full text Add to dashboard Cite

“…However, if smaller volumes are given and the amount of immunoglobins administered is marginal it should be fed by nipple bottle, since the absorption of immunoglobulins in this situation is superior to that of stomach tubed calves [67]. In the US feeding colostrum by oesophageal feeder is used as a routine measure in about 14% of dairy heifer calves [68]. In Europe the discussion surrounding force-feeding colostrum is somewhat controversial, and further complicated by the fact that animal welfare legislation in some countries prohibits force feeding of animals except for medical reasons [69].…”

Section: Colostrum Managementmentioning

confidence: 99%