An evaluation of selected oral health indicators and cariogenic bacteria titer in patients with Helicobacter pylori

Urban, J; Koszowski, Rafał; Płachetka, Anna; Wiczkowski, Andrzej

doi:10.17219/acem/61907

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…Within strains colonizing the oral cavity, only 16% expressed cagA, suggesting that this virulence factor is not critical in causing pathological changes to the oral cavity mucosa. 33 In another study using PCR, the DNA of oral H. pylori was isolated more frequently in patients with oral ailments (leukoplakia and oral lichen planus; 20% and 23%, respectively) than in those without these diseases (0%). The potential of these microorganisms to promote inflammatory conditions in the oral environment was proposed on this basis.…”

Section: Epidemiology Of Oral H Pylori Infectionsmentioning

confidence: 96%

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Krzyżek

Gościniak

2018

Dent. Med. Probl.

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The role of the oral cavity as a reservoir for Helicobacter pylori is still a controversial issue. There is a great number of articles indicating the presence of this pathogen in the oral cavity, but discrepancies among techniques for H. pylori detection and the variations in the patients tested often make it difficult to formulate a final verdict. Outer membrane proteins (OMPs) are one of the most important factors determining colonization of H. pylori in the oral cavity. Among them, the key role is attributed to BabA, SabA and NapA, all of which promote adherence and retention within this area. The oral cavity is characterized by the co-existence of numerous microorganisms which may potentially affect the physiology and morphology of H. pylori. The presence of coccoid-stimulating factors and relatively low levels of AI-2 in the early-to mid-stages of supragingival plaque allow dental H. pylori to colonize this niche as nonculturable spherical forms. On the other hand, subgingival plaque characterized by high numbers of periopathogens, capable of synthesizing high concentrations of AI-2, may favor the presence of mixed populations of spiral and coccoid H. pylori forms. This review article provides an up-to-date knowledge about the ability of oral H. pylori to interact both with the host and the local microflora of the oral cavity.

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Section: Epidemiology Of Oral H Pylori Infectionsmentioning

confidence: 96%

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Krzyżek

Gościniak

2018

Dent. Med. Probl.

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“…The study revealed that H. pylori DNA was seen in the oral cavity of 46% of the patients who showed positive results for the urease test which indicates the presence of H. pylori at the gastric level [6]. Similar results showed that 43% of the total 100 patients suffering from H. pylori infections in the GI tract exhibited colonization in the oral cavity [7]. Hence these authors established a relationship between dental caries, poor hygiene, and H. pylori.…”

Section: Introductionmentioning

confidence: 67%

“…Some studies have reported a positive correlation between H. pylori in the oral cavity and gastric infection, while others have found no significant association. Studies by Ding et al [ 20 ], Murad et al [ 25 ], and Urban J et al [ 7 ] found a positive correlation between H. pylori in the oral cavity and gastric infection, while studies by Dane et al [ 19 ] and Tavares et al [ 28 ] found no significant association. The remaining studies included in the table found mixed results.…”

Section: Reviewmentioning

confidence: 99%

The Association of Helicobacter pylori in the Oral Cavity With Dental Caries in Patients With and Without Gastric Infection: A Systematic Review

Abdul¹,

Alkhelaiwi²,

Alenazi³

et al. 2023

Cureus

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Helicobacter pylori ( H . pylori ) organisms are well-recognized pathogens responsible for many GI diseases. Streptococcus mutans- related caries and H. pylori infection share similar risk factors such as early childhood occurrence and low socioeconomic status. Therefore, it is possible for these two bacterial diseases to co-exist in the same environment. The present review evaluates the association of H . pylori with dental caries in patients with and without gastric infection, with the objective of comparing the association of H . pylori with dental caries in patients with and without gastric infection. A computerized literature search was performed in online databases from September 2000 to September 2022 using both electronic and manual searches for scientific databases. The research question was framed following the patient/population, intervention, comparison, and outcomes (PICO) statement. A thorough literature search identified a total of 200 manuscripts. Out of which, 100 were duplicate records and 100 were screened for eligibility, and about 78 articles were excluded, as they were not following PICO and the eligibility criterion. The retrieved 22 articles were sought for retrieval, only 17 were retrieved, and two studies did not fulfill the requirement. A total of 15 studies were recorded as eligible for the present review. There is a close association between the presence of infection of H. pylori in the oral cavity and the increased number of dental caries incidence in patients, even without a gastric infection. This suggests that the oral cavity is another niche for H. Pylori and may be the source of infection, re-infection, and transmission into the stomach.

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“…There are a few studies in the literature claiming to have isolated this bacterium from dental plaque, but without any definitve proof in terms of whole genome sequencing of the given isolate or deposition in a culture collection (Agarwal and Jithendra 2012;Wang et al 2014). Nevertheless, it was speculated that the oral cavity could also be a potential reservoir for this microorganism (Kignel et al 2005;Agarwal and Jithendra 2012;Wang et al 2014;Yee 2016; Urban et al 2017). In 2003, Rickard et al proposed that H. pylori was a typical colonizer of biofilms on the tooth surface in their diagrammatic representation of oral bacterial accretion on the tooth surface (Rickard et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Colonization ofHelicobacter pyloriin the oral cavity – an endless controversy?

Mao

Jakubovics

Bächle

et al. 2021

Critical Reviews in Microbiology

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Helicobacter pylori is associated with chronic gastritis, gastric or duodenal ulcers, and gastric cancer. Since the oral cavity is the entry port and the first component of the gastrointestinal system, the oral cavity has been discussed as a potential reservoir of H. pylori. Accordingly, a potential oral-oral transmission route of H. pylori raises the question concerning whether close contact such as kissing or sharing a meal can cause the transmission of H. pylori. Therefore, this topic has been investigated in many studies, applying different techniques for detection of H. pylori from oral samples, i.e. molecular techniques, immunological or biochemical methods and traditional culture techniques. While molecular, immunological or biochemical methods usually yield high detection rates, there is no definitive evidence that H. pylori has ever been isolated from the oral cavity. The specificity of those methods may be limited due to potential cross-reactivity, especially with H. pylori-like microorganisms such as Campylobacter spp. Furthermore, the influence of gastroesophageal reflux has not been investigated so far. This review aims to summarize and critically discuss previous studies investigating the potential colonization of H. pylori in the oral cavity and suggest novel research directions for targeting this critical research question.

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An evaluation of selected oral health indicators and cariogenic bacteria titer in patients with Helicobacter pylori

Abstract: Background. Studies based on polymerase chain reaction (PCR) techniques indicate that Helicobacter pylori can be constantly or temporarily present in the oral cavity in virulent or non-virulent form. Streptococcus mutans exerts a strong inhibitory effect on H. pylori.

Cited by 5 publications

References 21 publications

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

The Association of Helicobacter pylori in the Oral Cavity With Dental Caries in Patients With and Without Gastric Infection: A Systematic Review

Colonization ofHelicobacter pyloriin the oral cavity – an endless controversy?

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