An evaluation of the different biomarkers to discriminate bleeding in Crimean-Congo Hemorrhagic Fever

Büyüktuna, Seyit Ali; Doğan, Halef Okan; Ünlüsavuran, Meltem; Bakır, Mehmet

doi:10.1016/j.ttbdis.2019.05.008

Cited by 16 publications

(17 citation statements)

References 33 publications

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“…To summarize some of the studies carried out in line with the data obtained from laboratory findings in CCHF, it was reported by Büyüktuna et al that routine monitoring of AST levels may help patients with bleeding conditions and additionally reduce liver damage [22]. In addition, it was concluded that ferritin levels could be a potential biomarker that would be useful in monitoring patients.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of seroprevalence and clinical and laboratory findings of patients admitted to health institutions in Gümüşhane with suspicion of Crimean-Congo hemorrhagic fever

et al. 2021

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IntroductionCrimean-Congo hemorrhagic fever (CCHF) is a severe and fatal disease that is transmitted by ticks and often presents with bleeding symptoms in humans. The causative agent is the CCHF virus, an RNA virus of the Nairovirus lineage belonging to the family Bünyaviridae. It was first described in the Crimea in 1944, when it affected more than 200 people [1]. CCHF has been reported in more than 30 countries in Eastern Europe, Africa, the Balkans, Russia, Central Asian Republic, and the Middle East. The spread of the virus over a wide geographic area would result in a severe disease leading to high mortality in humans. The absence of a specific effective treatment and vaccine against the virus, in addition to its potential to be used as a bioterror agent or biological weapon, have made it an important human pathogen and a major public health problem worldwide [2]. In Turkey, CCHF is mainly seen in Erzurum,

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Section: Discussionmentioning

confidence: 95%

Evaluation of seroprevalence and clinical and laboratory findings of patients admitted to health institutions in Gümüşhane with suspicion of Crimean-Congo hemorrhagic fever

et al. 2021

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“…In this study, we detected the levels of serum ferritin in patients with HFRS and found that the concentrations of ferritin during the acute phase were signi cantly higher than that of the healthy controls, and increased with the exacerbation of the disease. This result re ected the so-called "cytokine storm" caused by super immune response after Hantavirus infection [26] and also indicated that ferritin can be used as a biomarker to evaluate the in ammatory state and oxidative stress, which with similar results in sepsis, COVID-19, Ebola viral disease and Crimean-Congo haemorrhagic fever [8][9][10][11]. The invasion of Hantavirus can cause excessive in ammation and massive in ammatory factors release, which may induce hepatocytes to synthesize and release ferritin.…”

Section: Discussionmentioning

confidence: 91%

“…In terms of viral infections, studies have also shown that serum ferritin is associated with viremia, in ammatory response and the death in patients with COVID-19, Ebola viral diseases and Crimean-Congo hemorrhagic fever [9][10][11], while with few studies on the dynamic changes of serum ferritin in patients with hemorrhagic fever with renal syndrome (HFRS), and the role of which in HFRS is still unclear. In this study, we observed the changes of serum ferritin in 102 HFRS patients with different clinical types and different stages, and investigated its predictive value on disease severity and prognosis (death) of HFRS patients.…”

Section: Introductionmentioning

confidence: 99%

The Expression of Serum Ferritin and Its Clinical Predictive Value in Patients With Hemorrhagic Fever With Renal Syndrome

Wang

Lian

et al. 2021

Preprint

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As a natural focus disease characterized by systemic immunopathological injury, there is a considerable diversity and heterogeneity in clinical course and prognosis of the patients with hemorrhagic fever with renal syndrome (HFRS). Therefore, the importance of early prediction and prognostic evaluation of severe patients in reducing mortality is self-evident. In this study, we detected the expression of serum ferritin and investigated its role on disease severity assessment and prognosis prediction in HFRS patients. The levels of serum ferritin in acute phase were higher than that of healthy controls and in convalescent phase of the same type, and gradually increased with the aggravation of the disease, which showed highest expression in the critical-type patients. Serum ferritin demonstrated significant correlations with conventional laboratory parameters (WBC, PLT, AST, ALB, APTT, Fib) and the length of hospital stay. High levels of ferritin were significantly associated with the death of HFRS, with a hazard ratio of 4.12. Serum ferritin showed a comparable predictive efficacy for the prognosis (death) of HFRS with that of conventional laboratory parameters, which with the AUC of 0.860 (95%CI: 0.782 ~ 0.938, P < 0.001). These results indicated that the detection of serum ferritin might be beneficial to early prediction and prognosis evaluation in severe HFRS patients and which is worthy of clinical application.

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“…However, these laboratory findings are known to be non-specific for CCHF (14). There is need for an easy, inexpensive, and perfect single biomarker for the diagnosis, follow-up, and prognosis of diseases like CCHF, and studies have been conducted to search for this type of biomarker (15,16). The aim of our study was to determine the diagnostic value of suPAR in the differential diagnosis of laboratory samples and clinically similar patients in the emergency department.…”

Section: E a R L Ymentioning

confidence: 99%

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Küçükceran

Karaşahin

Delice

et al. 2021

Düzce Tıp Fakültesi Dergisi

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Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types. Previous literature shows that the amount of soluble urokinase-type plasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congo hemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate the diagnostic value of suPAR in the differential diagnosis of CCHF in emergency services. Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHF disease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/or IgM positive (CCHF group) and RT-PCR and/or IgM negative (control group). Results: Eighty patients were included in this study. Forty patients with CCHF virus PCR and/or CCHF virus IgM were identified as CCHF group and 40 patients included as negative control group. The median age of the patients was 45 (range, 16-91) years, and 49 patients (61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, while creatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. There was no statistically significant difference between the control group and CCHF group for SuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF were examined, brucellosis, influenza, and pneumonia were found to be the most common. Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similar findings in emergency services was investigated and found to have no diagnostic value.

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An evaluation of the different biomarkers to discriminate bleeding in Crimean-Congo Hemorrhagic Fever

Cited by 16 publications

References 33 publications

Evaluation of seroprevalence and clinical and laboratory findings of patients admitted to health institutions in Gümüşhane with suspicion of Crimean-Congo hemorrhagic fever

Evaluation of seroprevalence and clinical and laboratory findings of patients admitted to health institutions in Gümüşhane with suspicion of Crimean-Congo hemorrhagic fever

The Expression of Serum Ferritin and Its Clinical Predictive Value in Patients With Hemorrhagic Fever With Renal Syndrome

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

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