An Evaluation of the Different Serum Markers Associated with Mortality in Crimean–Congo Hemorrhagic Fever

Abstract

Background Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with a high mortality rate. Although CCHF has been widely investigated over the past decade, a review of the literature indicated no data on the prognostic capacity of the mean platelet volume-to-platelet count ratio (MPVPCR) and the red cell distribution width-to-platelet count ratio (RDWPCR) for the systemic inflammatory response in patients with CCHF. This study aimed to evaluate the prognostic ability of MPVPCR and RDWPCR on mortality in patients with CCHF. Methods A total of 807 patients that were admitted to the Cumhuriyet University Hospital’s Emergency Department from January 2010 to December 2018 were involved. The RDWPCR and MPVPCR were separately calculated via absolute blood red cell and platelet counts at the time of admission. Before performing receiver-operating characteristic (ROC) curve analysis to define the optimum cut-off values of MPVPCR and RDWPCR stepwise logistic regression analysis was used to determine the predictive factors related to mortality in CCHF patients. Results Values of both MPVPCR and RDWPCR were significantly lower in survivors than in non-survivors (MPVPCR: 0.20±0.23 versus 0.55±0.55, P <0.001; RDWPCR: 0.27±0.32 versus 0.77±0.77, P <0.001, respectively). The MPVPCR (odds ratio [OR], 5.95; P =0.048) was an independent predictor for the prognosis of mortality in CCHF patients. The area under the curve in the ROC curve analysis for MPVPCR was 0.876 with a cut-off of 0.21 (sensitivity 87%, specificity 76%). Conclusion At the time of admission, MPVPCR might be a useful predictor of mortality in patients with CCHF.

Bioresorbable Scaffolds: Current Technology and Future Perspectives

“…We read with great interest the retrospective article of Tekin and Engin that investigated the prognostic significance of the ratio of mean platelet volume (MPV) to platelet count ratio (MPVPCR) in patients with Crimean-Congo hemorrhagic fever (CCHF). 1 The authors found that MPVPCR was significantly lower in survivors than in non-survivors, and therefore they suggested that this ratio could be used as a mortality marker. We think there are other factors that might have affected the results of this study.…”

Response to the Letter: Mean Platelet Volume to Platelet Count Value May Not Be a Prognostic Marker in Patients with Crimean–Congo Hemorrhagic Fever

“…We carefully read the comments of our respected colleagues Cengiz Beyan and Esin Beyan regarding our article, “An Evaluation of the Different Serum Markers Associated with Mortality in Crimean–Congo Hemorrhagic Fever.” 1 …”

Immature platelet fraction as a useful marker in Crimean-Congo hemorrhagic fever

“…Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne acute viral hemorrhagic disease characterized by fever and/or bleeding with a case fatality rate of 5-30% (Tekin & Engin, 2020). CCHF virus belongs to the Nairovirus genus in the Bunyaviridae family and is endemic in Africa, Asia, Eastern Europe, and the Middle East (Şensoy et al, 2011).…”