An evaluation of the effect of saffron supplementation on the antibody titer to heat-shock protein (HSP) 70, hsCRP and spirometry test in patients with mild and moderate persistent allergic asthma: A triple-blind, randomized placebo-controlled trial

Hosseini, Seyed Ahmad; Zilaee, Marzie; Shoushtari, Maryam Haddadzadeh; Dehcheshmeh, Mohammad Ghasemi

doi:10.1016/j.rmed.2018.10.016

Cited by 34 publications

(28 citation statements)

References 14 publications

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“…Saffron (Crocus sativus L.) has antioxidant [5], anti-inflammatory [6], and muscle relaxant effects [7] and so has beneficial effects on asthma. Results of our clinical trial showed that saffron supplementation (100 mg of dried saffron stigma in capsules) for 8 weeks in mild and moderate allergic asthmatic patients improved the lung function by increasing the forced expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC ratio, and forced expiratory flow (FEF) 25-75 and decreased some inflammatory factors (anti-HSP 70 and hs-CRP) in comparison to placebo [8]. In this trial the clinical symptoms of patients (including frequency of the shortness of breath during day-and nighttime, use of salbutamol spray, waking up due to asthma symptoms, and activity limitation) improved after saffron supplementation [9].…”

Section: Saffron and Asthmamentioning

confidence: 88%

Nutritional Recommendations in Asthmatic Patients

Zilaee¹,

Hosseini²

2019

Asthma - Biological Evidences

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Asthma is a heterogeneous disease, and airway inflammation has an important role in its pathogenesis. Some nutritional factors can influence the process of asthma. It is reported that saffron has anti-inflammatory, antioxidant, and muscle relaxant effects, and some animal and human studies showed that saffron and its active components (safranal and crocin) improved the asthma biomarkers and clinical symptoms. Some other nutritional factors also affect asthma; for example, magnesium can relax the muscles and thus has bronchodilatory effects. Curcumin is the major active component of turmeric which has a potent antioxidant, anti-inflammatory, and anti-allergic effects. Because some researchers suggested that intestinal microbial flora has an important role in allergy, probiotics can be a complementary supplement for asthmatic patients. Generally nutritional factors could be advised for asthmatic patients with the goal of reducing the needs for chemical drugs.

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Section: Saffron and Asthmamentioning

confidence: 88%

Nutritional Recommendations in Asthmatic Patients

Zilaee¹,

Hosseini²

2019

Asthma - Biological Evidences

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“…Several studies have listed the significant and nonsignificant effects of C sativus L supplements on the demographic, anthropometric, and clinical characteristics of asthma [ 6 , 8 , 9 ]. Hosseini et al [ 9 ] showed that C sativus L significantly affected anti-HSP and hs-CRP factor serum levels . Moreover, they showed that it increased the pulmonary volumes FEV 1 , FVC, FEV 1 /FVC, and FEF 25%-75% [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hosseini et al [ 9 ] showed that C sativus L significantly affected anti-HSP and hs-CRP factor serum levels . Moreover, they showed that it increased the pulmonary volumes FEV 1 , FVC, FEV 1 /FVC, and FEF 25%-75% [ 9 ]. They also showed that there was no significant effect on the eosinophil count [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies [ 6 , 8 , 9 ] have reported the effects of C sativus L on asthmatic patients. Zilaee et al [ 6 ] studied, in a randomized clinical trial, the effects of C sativus L supplements on clinical symptoms, Asthma Severity Score, blood pressure, and lipid profiles of patients with mild or moderate persistent allergic asthma.…”

Section: Introductionmentioning

confidence: 99%

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Neural Network–Based Clinical Prediction System for Identifying the Clinical Effects of Saffron (Crocus sativus L) Supplement Therapy on Allergic Asthma: Model Evaluation Study

et al. 2020

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Background Asthma is commonly associated with chronic airway inflammation and is the underlying cause of over a million deaths each year. Crocus sativus L, commonly known as saffron, when used in the form of traditional medicines, has demonstrated anti-inflammatory effects which may be beneficial to individuals with asthma. Objective The objective of this study was to develop a clinical prediction system using an artificial neural network to detect the effects of C sativus L supplements on patients with allergic asthma. Methods A genetic algorithm–modified neural network predictor system was developed to detect the level of effectiveness of C sativus L using features extracted from the clinical, immunologic, hematologic, and demographic information of patients with asthma. The study included data from men (n=40) and women (n=40) individuals with mild or moderate allergic asthma from 18 to 65 years of age. The aim of the model was to estimate and predict the level of effect of C sativus L supplements on each asthma risk factor and to predict the level of alleviation in patients with asthma. A genetic algorithm was used to extract input features for the clinical prediction system to improve its predictive performance. Moreover, an optimization model was developed for the artificial neural network component that classifies the patients with asthma using C sativus L supplement therapy. Results The best overall performance of the clinical prediction system was an accuracy greater than 99% for training and testing data. The genetic algorithm–modified neural network predicted the level of effect with high accuracy for anti–heat shock protein (anti-HSP), high sensitivity C-reactive protein (hs-CRP), forced expiratory volume in the first second of expiration (FEV1), forced vital capacity (FVC), the ratio of FEV1/FVC, and forced expiratory flow (FEF25%-75%) for testing data (anti-HSP: 96.5%; hs-CRP: 98.9%; FEV1: 98.1%; FVC: 97.5%; FEV1/FVC ratio: 97%; and FEF25%-75%: 96.7%, respectively). Conclusions The clinical prediction system developed in this study was effective in predicting the effect of C sativus L supplements on patients with allergic asthma. This clinical prediction system may help clinicians to identify early on which clinical factors in asthma will improve over the course of treatment and, in doing so, help clinicians to develop effective treatment plans for patients with asthma.

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“…The efficacy of saffron crocus has been clinically investigated in diabetes [180], asthma [181,182], cognitive impairment [183][184][185][186], glaucoma [187], macular degeneration related to age [188,189], sexual dysfunction in women [190] and men [191], and premenstrual syndrome [192]. These effects are out of the scope of the present thesis, therefore clinical and preclinical studies not related to the antidepressant activity are not discussed here.…”

Section: Pharmacological Activities Of Saffron Crocusmentioning

confidence: 99%

Phytochemical and pharmacological analysis of certain plants applied in the Iranian and European folk medicine

Mottaghipisheh

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An evaluation of the effect of saffron supplementation on the antibody titer to heat-shock protein (HSP) 70, hsCRP and spirometry test in patients with mild and moderate persistent allergic asthma: A triple-blind, randomized placebo-controlled trial

Cited by 34 publications

References 14 publications

Nutritional Recommendations in Asthmatic Patients

Nutritional Recommendations in Asthmatic Patients

Neural Network–Based Clinical Prediction System for Identifying the Clinical Effects of Saffron (Crocus sativus L) Supplement Therapy on Allergic Asthma: Model Evaluation Study

Phytochemical and pharmacological analysis of certain plants applied in the Iranian and European folk medicine

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