An evaluation of the effect of unoprostone isopropyl 0.15% on ocular hemodynamics in normal-tension glaucoma patients

Beano, F.; Orgül, Selim; Stümpfig, Daniela; Gugleta, Konstantin

doi:10.1007/s004170000233

Cited by 12 publications

(2 citation statements)

References 36 publications

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“…A recent study in patients with normal-tension glaucoma did not show an effect of topical unoprostone on ocular hemodynamic variables. 34 Although patients included in this trial were tested for vasospastic diathesis, the local level of ET-1 in the eye was unknown. Moreover, short-term experiments applying high doses of unoprostone are not necessarily comparable to long-term effects of unoprostone in patients with glaucoma, and it is unclear whether a functional antagonism may also be achieved with lower doses of the drug.…”

Section: Discussionmentioning

confidence: 99%

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl

Polska

Doelemeyer²,

Luksch³

et al. 2002

Arch Ophthalmol

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Background: There is increasing evidence that reduced ocular blood flow plays a role in the pathogenesis of glaucoma. In patients with normal-tension glaucoma, ocular blood flow abnormalities may be associated with dysfunction of the endothelin 1 (ET-1) regulation system. Objective: To test the hypothesis that unoprostone, a topical docosanoid, may affect ET-1-induced vasoconstriction in the human choroid. Methods: In a placebo-controlled, randomized, doublemasked, 2-way crossover design, ET-1 (2.5 ng/kg per minute for 150 minutes) was administered intravenously to 24 healthy individuals. Thirty minutes after the start of ET-1 infusion, 1 drop of unoprostone or placebo was instilled into the right eye. After another 30 minutes, 2 drops of unoprostone or placebo was topically administered. This procedure was continued and the dose was increased further until 4 drops of unoprostone or placebo was reached. Subfoveal and pulsatile choroidal blood flow were assessed using laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively. Results: Administration of exogenous ET-1 decreased choroidal blood flow (mean±SEM, 17%±2%; PϽ.001) and fundus pulsation amplitude (mean±SEM, 19%±2%; PϽ.001). This effect was significantly blunted when topical unoprostone was coadministered (mean ± SEM decrease in choroidal blood flow, 7%±2%; P =.04 vs placebo; mean±SEM decrease in fundus pulsation amplitude, 12%±2%; PϽ.001 vs placebo). Conclusion: There is a functional antagonism between ET-1 and topical unoprostone in the choroidal vasculature. Clinical Relevance: Our findings of a functional antagonism between ET-1 and topical unoprostone in the choroidal vasculature may be important in vascular eye diseases associated with increased ET-1.

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Section: Discussionmentioning

confidence: 99%

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl

Polska

Doelemeyer²,

Luksch³

et al. 2002

Arch Ophthalmol

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“…Claims on potential beneficial effects of unoprostone on ocular blood flow could not be confirmed in a prospective, randomized, observer-masked, two-period crossover, placebo-controlled trial [65]. Several reports had suggested a beneficial effect of latanoprost on pulsatile ocular blood flow in glaucoma patients [66,67,68], but after adjustment of the measured outcome for the effect of the treatment on IOP [69] it could be shown that the former result was simply related to the reduction of the IOP and no improvement of vascular functions seems to occur with this substance.…”

Section: Therapeutic Modalitiesmentioning

confidence: 99%

Therapeutic Strategies for Normal-Tension Glaucoma

Orgül¹,

Zawinka²,

Gugleta³

2005

Ophthalmologica

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Treatment of normal-tension glaucoma has been a subject of debate for several years. Glaucomatous damage cannot be influenced directly, and current treatment modalities in normal-tension glaucoma are aimed at the control of risk factors. Intraocular pressure is a widely accepted risk factor and its reduction can improve the prognosis in normal-tension glaucoma patients. The repeated demonstration of the importance of hemodynamic factors in normal-tension glaucoma has, however, not been paralleled by a comparable progress in the development of therapeutic modalities capable of influencing favorably ocular blood flow. Today, calcium channel blockers seem to be the most promising adjunctive treatment to be considered in patients with glaucomatous optic neuropathy without increased intraocular pressure.

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Endothelial and Adrenergic Control

Garhöfer

Schmetterer

2012

Ocular Blood Flow

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An evaluation of the effect of unoprostone isopropyl 0.15% on ocular hemodynamics in normal-tension glaucoma patients

Abstract: Unoprostone isopropyl did not induce any alterations in ocular hemodynamics in this pilot study with vasospastic normal-tension glaucoma patients.

Cited by 12 publications

References 36 publications

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl

Therapeutic Strategies for Normal-Tension Glaucoma

Endothelial and Adrenergic Control

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